Acceleration to Death from Liver Cancer in People with Hepatitis B Viral Mutations Detected in Plasma by Mass Spectrometry

Autor: Patricia A. Egner, Jianguo Chen, Tao Yang Chen, Alvaro Muñoz, John D. Groopman, Yuan Rong Zhu, Bao Chu Zhang, Shuang Yuan Kuang, Jian Hua Lu, Jin Bing Wang, Thomas W. Kensler

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 16:1213-1218

Liver cancer is the leading cause of cancer death in many regions of the world. With the goal to discover biomarkers that reflect subsets of high-risk individuals and their prognosis, we nested our study in a male cohort of 5,581 hepatitis B surface

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6ad019605adc7d34164f91e372f391
https://doi.org/10.1158/1055-9965.epi-06-0905

Chlorophyllin intervention reduces aflatoxin–DNA adducts in individuals at high risk for liver cancer

Autor: Jin Bing Wang, Lisa P. Jacobson, Shuang Yuan Kuang, Thomas W. Kensler, Patricia A. Egner, Kathy J. Helzlsouer, Geng Sun Qian, Qi Nan Zhang, John D. Groopman, Stephen J. Gange, George S. Bailey, Bao Chu Zhang, Yuan Rong Zhu, Yan Wu

Publikováno v: Proceedings of the National Academy of Sciences. 98:14601-14606

Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part from consumption of foods contaminated with aflatoxins. Chlorophyllin, a mixture of semisynthetic, water-soluble derivatives of chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2499244cf0d73d5c174e298d492fd43
https://doi.org/10.1073/pnas.251536898

Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China

Autor: Thomas W. Kensler, Hans J. Prochaska, Shuang Yuan Kuang, Baibai Chen, Jia-Sheng Wang, Geng Sun Qian, Mary B. Gorman, John D. Groopman, Xia He, Yuan Rong Zhu, Bao Chu Zhang, Audrey Zarba, Lu Yi Yu, Kathy J. Helzlsouer, Patricia A. Egner, Yan Wu, Xi Fang, Alvaro Muñoz, Yan Feng Li, Cheryl Enger, Lisa P. Jacobson, Gary B. Gordon, Jin Bing Wang, Silvio De Flora, Qi Nan Zhang, Nancy E. Davidson

Publikováno v: Journal of Cellular Biochemistry. 67:166-173

Oltipraz has been used clinically in many regions of the world as an antischistosomal agent and is an effective inhibitor of aflatoxin hepatocarcinogenesis in rats. This chemopreventive action of oltipraz results primarily from an altered balance in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::712c4f591bc46fda7a7428e31c1058f5
https://doi.org/10.1002/(sici)1097-4644(1997)28/29+<166::aid-jcb20>3.0.co

Strategies for chemoprevention of liver cancer

Autor: Thomas W, Kensler, Patricia A, Egner, Jin-Bing, Wang, Yuan-Rong, Zhu, Bao-Chu, Zhang, Geng-Sun, Qian, Shuang-Yuan, Kuang, Stephen J, Gange, Lisa P, Jacobson, Alvaro, Muñoz, John D, Groopman

Publikováno v: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 11

Liver cancer is one of the most common cancers worldwide. Infection with hepatitis B virus and exposure to aflatoxins in the diet act synergistically to amplify risk. From a public health perspective, hepatitis virus vaccination programs and efforts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac11bc8de1d454d983bb68124c61c323
https://pubmed.ncbi.nlm.nih.gov/12570336

Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver...

Autor: Egner, Patricia A., Jin-Bing Wang, Yuan-Rhong Zhu, Bao-Chu Zhang, Yan Wu, Qi-Nan Zhang, Geng-Sun Qian, Shuang-Yuan Kuang, Gange, Stephen J., Jacobson, Lisa P., Helzlsouer, Kathy J., Bailey, George S., Groopman, John D., Kensler, Thomas W.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 12/4/2001, Vol. 98 Issue 25, p14601, 6p, 2 Diagrams, 1 Chart, 6 Graphs