Investigating the regulation of ACC1 activity in pancreatic beta cells

Autor: Bany Bakar, R

Aims: Acetyl-coA Carboxylase 1 (ACC1) is an enzyme that couples glucose metabolism with de novo lipid synthesis in lipogenic tissues, by converting acetyl-CoA to malonyl-CoA. In beta cells, ACC1 plays a critical role in beta cell growth and insulin s

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https://ora.ox.ac.uk/objects/uuid:0a80546e-56f6-4399-a102-0ee5dbef472b

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Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.

Autor: Nasteska D; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom., Cuozzo F; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom., Viloria K; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom., Johnson EM; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom., Thakker A; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Bany Bakar R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Westbrook RL; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Barlow JP; Mitochondrial Profiling Centre, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom., Hoang M; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Joseph JW; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Lavery GG; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Akerman I; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Cantley J; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; Division of Systems Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom., Hodson L; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom., Tennant DA; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom., Hodson DJ; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, United Kingdom.

Publikováno v: JCI insight [JCI Insight] 2021 Aug 23; Vol. 6 (16). Date of Electronic Publication: 2021 Aug 23.