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Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity.

Autor: Lietz CB; Department of Pharmaceutical Candidate Optimization - DMPK, Bristol Myers Squibb, San Diego, CA, USA., Deyanova E; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, Lawrenceville, NJ, USA., Cho Y; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA., Cordia J; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA., Franc S; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA., Kabro S; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA., Wang S; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA., Mikolon D; Department of Biotherapeutics, Bristol Myers Squibb, San Diego, CA, USA., Banks DD; Department of Pharmaceutical Candidate Optimization - DPAS, Bristol Myers Squibb, San Diego, CA, USA.

Publikováno v: MAbs [MAbs] 2023 Jan-Dec; Vol. 15 (1), pp. 2259289. Date of Electronic Publication: 2023 Sep 24.

Isotonic concentrations of excipients control the dimerization rate of a therapeutic immunoglobulin G1 antibody during refrigerated storage based on their rank order of native-state interaction.

Autor: Banks DD; Department of Biologics Drug Product Development, Celgene Corp, 10300 Campus Point Drive Suite 100, San Diego, California, 92121., Cordia JF; Department of Biologics Drug Product Development, Celgene Corp, 10300 Campus Point Drive Suite 100, San Diego, California, 92121., Spasojevic V; Department of Biologics Drug Product Development, Celgene Corp, 10300 Campus Point Drive Suite 100, San Diego, California, 92121., Sun J; Department of Biotherapeutics, Celgene Corp, 10300 Campus Point Drive Suite 100, San Diego, California, 92121., Franc S; Department of Biologics Drug Product Development, Celgene Corp, 10300 Campus Point Drive Suite 100, San Diego, California, 92121., Cho Y; Department of Biologics Drug Product Development, Celgene Corp, 10300 Campus Point Drive Suite 100, San Diego, California, 92121.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2018 Dec; Vol. 27 (12), pp. 2073-2083.

Effects of sucrose and benzyl alcohol on GCSF conformational dynamics revealed by hydrogen deuterium exchange mass spectrometry.

Autor: Zhang J; Drug Product Development, Amgen Inc., Seattle, Washington, 98119., Banks DD, He F, Treuheit MJ, Becker GW

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2015 May; Vol. 104 (5), pp. 1592-600. Date of Electronic Publication: 2015 Feb 18.