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A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria.

Autor: Chahine Z; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Abel S; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Hollin T; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Barnes GL; Department of Chemistry, University of California, Irvine, CA, USA., Chung JH; Department of Chemistry, University of California, Irvine, CA, USA., Daub ME; Department of Chemistry, University of California, Irvine, CA, USA., Renard I; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Choi JY; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Vydyam P; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Pal A; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Alba-Argomaniz M; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA., Banks CAS; Stowers Institute for Medical Research, Kansas City, MO, USA., Kirkwood J; Metabolomics Core Facility, University of California, Riverside, CA, USA., Saraf A; Stowers Institute for Medical Research, Kansas City, MO, USA.; Present address: Shankel Structural Biology Center, The University of Kansas, Lawrence, KS, USA., Camino I; GSK, Tres Cantos (Madrid), Spain., Castaneda P; GSK, Tres Cantos (Madrid), Spain., Cuevas MC; GSK, Tres Cantos (Madrid), Spain., De Mercado-Arnanz J; GSK, Tres Cantos (Madrid), Spain., Fernandez-Alvaro E; GSK, Tres Cantos (Madrid), Spain., Garcia-Perez A; GSK, Tres Cantos (Madrid), Spain., Ibarz N; GSK, Tres Cantos (Madrid), Spain., Viera-Morilla S; GSK, Tres Cantos (Madrid), Spain., Prudhomme J; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA., Joyner CJ; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA., Bei AK; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Florens L; Stowers Institute for Medical Research, Kansas City, MO, USA., Ben Mamoun C; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Vanderwal CD; Department of Chemistry, University of California, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA., Le Roch KG; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Sep 27; Vol. 385 (6716), pp. eadm7966. Date of Electronic Publication: 2024 Sep 27.

An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome.

Autor: Liu X; Stowers Institute for Medical Research, Kansas City, MO 64110., Zhang Y; Stowers Institute for Medical Research, Kansas City, MO 64110., Wen Z; Stowers Institute for Medical Research, Kansas City, MO 64110., Hao Y; Stowers Institute for Medical Research, Kansas City, MO 64110., Banks CAS; Stowers Institute for Medical Research, Kansas City, MO 64110., Cesare J; Stowers Institute for Medical Research, Kansas City, MO 64110.; Medical Scientist Training Program, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66150., Bhattacharya S; Stowers Institute for Medical Research, Kansas City, MO 64110., Arvindekar S; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India., Lange JJ; Stowers Institute for Medical Research, Kansas City, MO 64110., Xie Y; Department of Biochemistry and Molecular Biophysics, Washington University St. Louis School of Medicine, St. Louis, MO 63110., Garcia BA; Department of Biochemistry and Molecular Biophysics, Washington University St. Louis School of Medicine, St. Louis, MO 63110., Slaughter BD; Stowers Institute for Medical Research, Kansas City, MO 64110., Unruh JR; Stowers Institute for Medical Research, Kansas City, MO 64110., Viswanath S; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India., Florens L; Stowers Institute for Medical Research, Kansas City, MO 64110., Workman JL; Stowers Institute for Medical Research, Kansas City, MO 64110., Washburn MP; Stowers Institute for Medical Research, Kansas City, MO 64110.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 13; Vol. 121 (33), pp. e2318601121. Date of Electronic Publication: 2024 Aug 08.