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The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.

Autor: Czimmerer Z; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Daniel B; Sanford-Burnham-Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA., Horvath A; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Rückerl D; Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, UK., Nagy G; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; MTA-DE 'Lendület' Immunogenomics Research Group, University of Debrecen, Debrecen, Hungary., Kiss M; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Peloquin M; Sanford-Burnham-Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA., Budai MM; Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Cuaranta-Monroy I; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Simandi Z; Sanford-Burnham-Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA., Steiner L; UD-Genomed Medical Genomic Technologies Ltd., Debrecen, Hungary., Nagy B Jr; Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Poliska S; Genomic Medicine and Bioinformatic Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Banko C; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Bacso Z; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Schulman IG; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA., Sauer S; Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Berlin, Germany; CU Systems Medicine, University of Würzburg, Würzburg, Germany; Max Delbrück Center for Molecular Medicine (BIMSB and BIH), Berlin, Germany., Deleuze JF; Centre National de Génotypage, Institut de Génomique, CEA, Evry, France., Allen JE; Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, UK., Benko S; Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Nagy L; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Sanford-Burnham-Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA; MTA-DE 'Lendület' Immunogenomics Research Group, University of Debrecen, Debrecen, Hungary. Electronic address: lnagy@sbpdiscovery.org.

Publikováno v: Immunity [Immunity] 2018 Jan 16; Vol. 48 (1), pp. 75-90.e6.

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