Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Bangyan L Stiles"'
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204043 (2018)
Insulin resistance-as observed in aging, diabetes, obesity, and other pathophysiological situations, affects brain function, for insulin signaling is responsible for neuronal glucose transport and control of energy homeostasis and is involved in the
Externí odkaz:
https://doaj.org/article/8b1358831bc5440cb7c88ef3284607cd
Autor:
Colin T Shearn, David J Orlicky, Rebecca L McCullough, Hua Jiang, Kenneth N Maclean, Kelly E Mercer, Bangyan L Stiles, Laura M Saba, Martin J Ronis, Dennis R Petersen
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154152 (2016)
Alcoholic liver disease is a significant contributor to global liver failure. In murine models, chronic ethanol consumption dysregulates PTEN/Akt signaling. Hepatospecific deletion of phosphatase and tensin homolog deleted on chromosome 10 (PTENLKO)
Externí odkaz:
https://doaj.org/article/26671a9f1cd94781bdbb71a1ef7e860b
Autor:
Zhigang Liu, Ishan Y Patil, Tianyi Jiang, Harsh Sancheti, John P Walsh, Bangyan L Stiles, Fei Yin, Enrique Cadenas
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128274 (2015)
High-fat diet (HFD)-induced obesity is associated with insulin resistance, which may affect brain synaptic plasticity through impairment of insulin-sensitive processes underlying neuronal survival, learning, and memory. The experimental model consist
Externí odkaz:
https://doaj.org/article/1be50d6f8b234e90a4405d08238056f9
Autor:
Beth M Palian, Aarti D Rohira, Sandra A S Johnson, Lina He, Ni Zheng, Louis Dubeau, Bangyan L Stiles, Deborah L Johnson
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004789 (2014)
Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function. Here, we show that Maf1 is a key downstream target of PTEN that driv
Externí odkaz:
https://doaj.org/article/e38c2cb4eebf48cda6c3dec09f109d6e
Autor:
Colin T Shearn, Kelly E Mercer, David J Orlicky, Leah Hennings, Rebecca L Smathers-McCullough, Bangyan L Stiles, Martin J J Ronis, Dennis R Petersen
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96553 (2014)
Hepatospecific deletion of PTEN results in constitutive activation of Akt and increased lipogenesis. In mice, the addition of a high fat diet (HFD) downregulates lipogenesis. The aim of this study was to determine the effects of a HFD on hepatocellul
Externí odkaz:
https://doaj.org/article/68d583e19f9d478cbaab11e66f0aad96
Autor:
Mario M. Alba, Brandon Ebright, Brittney Hua, Ielyzaveta Slarve, Yiren Zhou, Yunyi Jia, Stan G. Louie, Bangyan L. Stiles
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Liver cancer is a malignancy developed from underlying liver disease that encompasses liver injury and metabolic disorders. The progression from these underlying liver disease to cancer is accompanied by chronic inflammatory conditions in which liver
Externí odkaz:
https://doaj.org/article/6763cc456c964e20abb8e8bec18630f7
Autor:
Taojian Tu, Mario M. Alba, Aditi A. Datta, Handan Hong, Brittney Hua, Yunyi Jia, Jared Khan, Phillip Nguyen, Xiatoeng Niu, Pranav Pammidimukkala, Ielyzaveta Slarve, Qi Tang, Chenxi Xu, Yiren Zhou, Bangyan L. Stiles
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Obesity confers an independent risk for carcinogenesis. Classically viewed as a genetic disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone are not sufficient to explain the progression and development of cancers.
Externí odkaz:
https://doaj.org/article/55ba334f1c884f55b8521a34fc833786
