Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial

Autor: Gordon, AC, Mason, AJ, Thirunavukkarasu, N, Perkins, GD, Cecconi, M, Cepkova, M, Pogson, DG, Aya, HD, Anjum, A, Frazier, GJ, Santhakumaran, S, Ashby, D, Brett, SJ, VANISH Investigators, COLLABORATORS, Warwick, J, Griffiths, S, Cross, M, Mason, A, Frazier, G, Das, N, Bellingan, G, Gordon, A, Brett, S, Perkins, G, Beale, R, Banks, F, Watts, T, Andrews, P, McAuley, D, Collier, T, Templeton, M, Errington, E, Gladas, K, Banach, D, Kitson, D, Matthew-Thomas, R, Hauer, V, Ochelli-Okpue, A, Stotz, M, Ostermann, M, Lei, K, Chan, K, Smith, J, Shankar-Hari, M, Carungcong, J, Handy, J, Hopkins, P, Harris, CL, Wade-Smith, F, Birch, S, Hurst, T, Mellinghoff, J, Di Tomasso, N, Ebm, C, Iannucceli, F, Kirwan, CJ, Creary, T, Correia, C, Prowle, JR, Jaques, N, Brown, A, Walden, A, Joscak, J, Bangalan, J, Tamm, T, Snow, L, Stapleton, C, Pahary, SM, Gould, T, Bewley, J, Sweet, K, Grimmer, L, Shah, S, Williams, S, Pulletz, M, Golder, K, Bolger, C, Salmon, K, Skinner, B, Vickers, E, Scott, M, Rose, S, Lamb, N, Mouland, J, Pogson, D, Bullock, L, Bland, M, Harrison-Briggs, D, Wilkinson, K, Krige, A, Ward, G, Ting, J, Bassford, C

Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative. To compare the effect of early vasopressin vs norepinephrine on kidney failure in patients with

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