Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bang-Lin Wan"'
Autor:
Casey L. Mahoney-Crane, Megha Viswanathan, Dreson Russell, Rachel A.C. Curtiss, Jennifer Freire, Sai Sumedha Bobba, Sean D. Coyle, Monika Kandebo, Lihang Yao, Bang-Lin Wan, Nathan G. Hatcher, Sean M. Smith, Jacob N. Marcus, Laura A. Volpicelli-Daley
Publikováno v:
The Journal of Neuroscience. 43:501-521
The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutationsGBA1, which encodes for the lysosomal enzyme, glucocerebrosidase. Reduced glucocerebrosidase activity associates with an accumulation of abnormal α-synuclein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e53fa31184f65b618e50145e3c5d29
https://doi.org/10.1523/jneurosci.0680-22.2022
https://doi.org/10.1523/jneurosci.0680-22.2022
Autor:
Mahoney-Crane, Casey L., Viswanathan, Megha, Russell, Dreson, Curtiss, Rachel A. C., Freire, Jennifer, Bobba, Sai Sumedha, Coyle, Sean D., Kandebo, Monika, Lihang Yao, Bang-Lin Wan, Hatcher, Nathan G., Smith, Sean M., Marcus, Jacob N., Volpicelli-Daley, Laura A.
Publikováno v:
Journal of Neuroscience; 1/18/2023, Vol. 43 Issue 3, p501-521, 21p
Autor:
Jill Maxwell, Bonnie J. Howell, Alexey Nefedov, William Newhard, Justin Steve, Bang-Lin Wan, Daria J. Hazuda, David M. Tellers, Sai V. Vemula, Andrea L. Webber, Wade Blair, Richard J. O. Barnard, Rosa I. Sanchez
Publikováno v:
Antiviral research. 139
Design The HIV latent CD4+ T cell reservoir is broadly recognized as a barrier to HIV cure. Induction of HIV expression using protein kinase C (PKC) agonists is one approach under investigation for reactivation of latently infected CD4+ T cells (Bean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ba296e694d36ab85b7d333841ff2fb
https://pubmed.ncbi.nlm.nih.gov/27889530
https://pubmed.ncbi.nlm.nih.gov/27889530
Autor:
John A. McCauley, Kevin Nguyen, Anne Taylor, Joseph J. Romano, Steven S. Carroll, Nicole Trainor, Qian Huang, Stephanie McClain, M. Katharine Holloway, Joseph P. Vacca, Jillian DiMuzio, Christine Burlein, Christine Fandozzi, Carolyn McHale, Vincenzo Summa, Michael Rowley, John W. Butcher, Nigel J. Liverton, Charles J. Mcintyre, Adam Gates, Bang-Lin Wan, Michael T. Rudd, Donald J. Graham, Steven Harper, David B. Olsen, Terry A. Lyle, Kevin F. Gilbert, Mark Stahlhut, Kimberly J. Bush, Steven W. Ludmerer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7207-7213
A series of macrocyclic compounds containing a cyclic constraint in the P2–P4 linker region have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155 K, A156T, A156 V, and D168 V mutant activity while maintaini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb557fdc755adc3a67b410d163da85
https://doi.org/10.1016/j.bmcl.2012.09.061
https://doi.org/10.1016/j.bmcl.2012.09.061
Autor:
Yuexia Liang, Daniel DeStefano, Samson M. Jolly, Georgia B. McGaughey, Joe P. Vacca, Bang-Lin Wan, Michael W. Miller, Robert P. Gomez, Youwei Yan, Sinoeun Touch, Neville J. Anthony, Robert M. Tynebor, Ming-Tain Lai, Rosa I. Sanchez, Vandna Munshi, Thomas J. Tucker, Theresa M. Williams, Peter J. Felock, Brenda Paton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7344-7350
Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b31490ebe226d08d8789ee8cd109a3
https://doi.org/10.1016/j.bmcl.2011.10.027
https://doi.org/10.1016/j.bmcl.2011.10.027
Autor:
John Swestock, Christine Fandozzi, John A. McCauley, Nicole Trainor, Bang-Lin Wan, M. Katharine Holloway, Donald J. Graham, Charles J. Mcintyre, Nigel J. Liverton, Joseph J. Romano, Michael T. Rudd, John W. Butcher, Steven S. Carroll, Mark Stahlhut, Kevin F. Gilbert, Jillian DiMuzio, David B. Olsen, Steven W. Ludmerer, Kimberly J. Bush, Kevin Nguyen, Joseph P. Vacca
Publikováno v:
ACS Medicinal Chemistry Letters. 2:207-212
The discovery of MK-1220 is reported along with the development of a series of HCV NS3/4A protease inhibitors containing a P2 to P4 macrocyclic constraint with improved preclinical pharmacokinetics. Optimization of the P2 heterocycle substitution pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b87d35ae01567431ecab1fba89870b
https://doi.org/10.1021/ml1002426
https://doi.org/10.1021/ml1002426
Autor:
Nicole Trainor, Christine Fandozzi, Kevin F. Gilbert, Joseph J. Romano, Bang-Lin Wan, Shi-Shan Mao, John Swestock, John A. McCauley, M. Katharine Holloway, David B. Olsen, Nigel J. Liverton, Kimberly J. Bush, Donald J. Graham, Mark Stahlhut, Steven S. Carroll, John W. Butcher, Steven W. Ludmerer, Michael T. Rudd, Jillian DiMuzio, Kevin Nguyen, Joseph P. Vacca, Charles J. Mcintyre
Publikováno v:
Journal of Medicinal Chemistry. 53:2443-2463
A new class of HCV NS3/4a protease inhibitors which contain a P2 to P4 macrocyclic constraint was designed using a molecular-modeling derived strategy. Exploration of the P2 heterocyclic region, the P2 to P4 linker, and the P1 side chain of this clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca278167f94eed395382711e9a327f60
https://doi.org/10.1021/jm9015526
https://doi.org/10.1021/jm9015526
Autor:
Theresa M. Williams, Youwei Yan, Michael W. Miller, Joseph P. Vacca, Rebecca Perlow-Poehnelt, Bang-Lin Wan, Ming-Tain Lai, Sridhar Prasad, Saggar Sandeep A, Georgia B. McGaughey, Maricel Torrent, Robert M. Tynebor, Rosa I. Sanchez, John T. Sisko, Yuexia Liang, Peter J. Felock, Jessica A. Flynn, Thomas J. Tucker, Meiquing Liu, Gregory Moyer, Vandna Munshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2959-2966
Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f89230b4fd01e13b8d56f9729d01d8e
https://doi.org/10.1016/j.bmcl.2008.03.064
https://doi.org/10.1016/j.bmcl.2008.03.064
Autor:
Jacquelynn J. Cook, Rodney A. Bednar, Thomayant Prueksaritanont, Yvonne M. Leonard, Michael R. Wood, Qin Mei, Richard W. Ransom, Ronald K. Chang, Emily D. Adarayn, Robert M. DiPardo, Jian Yu, Audrey A. Wallace, Wei Lemaire, Scott D. Kuduk, Kathy L. Murphy, G. R. Sitko, Scott D. Mosser, Christina N. Di Marco, Mark G. Bock, Frank C. Clayton, Bang-Lin Wan, Kathy M. Schirripa, Marie A. Holahan, Roger M. Freidinger, Dennis L. Bohn, Douglas J. Pettibone, Raymond S.L. Chang, Cuyue Tang, June J. Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:716-720
Antagonism of the bradykinin B1 receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists incorporating α-hydroxy amides were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f489daa5ddd1907e6d600a79ad35db5d
https://doi.org/10.1016/j.bmcl.2007.11.050
https://doi.org/10.1016/j.bmcl.2007.11.050
Autor:
Diem N. Nguyen, Samuel L. Graham, Theresa M. Williams, Scott D. Mosser, Ian M. Bell, Bang-Lin Wan, Kimberly Della Penna, Priya Kunapuli, Stefanie A. Kane, Craig A. Stump, Ruth Z. Rutledge, John F. Fay, Ken S. Koblan, Joseph P. Vacca, C. Blair Zartman, Steven N. Gallicchio, Amy G. Quigley, Christopher A. Salvatore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2595-2598
High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6628f20dd0bcf6f444b0f155b9357fdc
https://doi.org/10.1016/j.bmcl.2006.02.051
https://doi.org/10.1016/j.bmcl.2006.02.051