Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Bang V. Bui"'
Autor:
Paul Trlin, Jenny Gong, Katie K. N. Tran, Vickie H. Y. Wong, Pei Ying Lee, Anh Hoang, Da Zhao, Leah C. Beauchamp, Jeremiah K. H. Lim, Andrew Metha, Kevin J. Barnham, David I. Finkelstein, Bang V. Bui, Phillip Bedggood, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s disease is another neurodegenerative disease where brain pathobiology such as alpha-synuclein and iron over
Externí odkaz:
https://doaj.org/article/4922d8416bbd4e5ca8336a9df43afadf
Autor:
Katie K. N. Tran, Vickie H. Y. Wong, Kirstan A. Vessey, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 130 (2024)
Background: Loss of substantia nigra dopaminergic cells and alpha-synuclein (α-syn)-rich intraneuronal deposits within the central nervous system are key hallmarks of Parkinson’s disease (PD). Levodopa (L-DOPA) is the current gold-standard treatme
Externí odkaz:
https://doaj.org/article/bc49c8d44bd9418990fec166293f6114
Autor:
Katie K. N. Tran, Vickie H. Y. Wong, Anh Hoang, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of the pathological hallmarks of Parkinson’s disease’s (PD). This study considers the potential utility of PD retinal biomarkers by investigating retinal changes
Externí odkaz:
https://doaj.org/article/7914c93654a74f62859b382945c94c8a
Autor:
Katie K. N. Tran, Vickie H. Y. Wong, Jeremiah K. H. Lim, Ali Shahandeh, Anh Hoang, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Parkinson’s disease (PD). A better understanding of the mechanisms underlying these changes would facilitate the
Externí odkaz:
https://doaj.org/article/2ca2db10f64c4d158e15ba9dcf88633e
Autor:
Wilson J. Heriot, MB, BS, Andrew B. Metha, PhD, BScOptom, Zheng He, PhD, MSci, Jeremiah K.H. Lim, PhD, Anh Hoang, BSci, Tomoharu Nishimura, PhD, MD, Mali Okada, MBBS, Bang V. Bui, PhD, BSciOptom
Publikováno v:
Ophthalmology Science, Vol 2, Iss 4, Pp 100179- (2022)
Purpose: Rhegmatogenous retinal detachment repair by intraoperative sealing of the tear without a tamponade agent should enable faster restoration of vision and resumption of normal activities. It avoids the need for further surgery in the case of si
Externí odkaz:
https://doaj.org/article/e39bc07593e54d4cbabafc816c6ca486
Autor:
Jeremiah K. H. Lim, Qiao-Xin Li, Tim Ryan, Phillip Bedggood, Andrew Metha, Algis J. Vingrys, Bang V. Bui, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) protein in the eyes of those with Alzheimer’s disease (AD). The concept of using the retina as a biomarker for
Externí odkaz:
https://doaj.org/article/28ea0fabc8e749f5be0e21a89d4e8ea5
Autor:
Anna Y. M. Wang, Vickie H. Y. Wong, Pei Ying Lee, Bang V. Bui, Stefanie Dudczig, Kirstan A. Vessey, Erica L. Fletcher
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in animal models. In addition, the P2X7-receptor (P2X7-R) has been suggested to contribute to RGC death following sti
Externí odkaz:
https://doaj.org/article/d9083722c2204c03bafe2c974c82c662
Autor:
Pei Ying Lee, Da Zhao, Vickie H. Y. Wong, Vicki Chrysostomou, Jonathan G. Crowston, Bang V. Bui
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Aging and elevated intraocular pressure (IOP) are two major risk factors for glaucomatous optic neuropathy; a condition characterized by the selective, progressive injury, and subsequent loss of retinal ganglion cells (RGCs). We examined how age modi
Externí odkaz:
https://doaj.org/article/3468887849d840659285d4246cc02d29
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iron, however, can promote toxicity and cell death. An example of an iron overload disorder is hemochromatosis (HH) which i
Externí odkaz:
https://doaj.org/article/a254b801aaa1475983014e3114e40db2
Autor:
Xavier Hadoux, Flora Hui, Jeremiah K. H. Lim, Colin L. Masters, Alice Pébay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J. Fowler, Christopher Rowe, Victor L. Villemagne, Edward N. Taylor, Christopher Fluke, Jean-Paul Soucy, Frédéric Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S. Nasreddine, Jean Daniel Arbour, Marc-André Rhéaume, Sylvain Beaulieu, Mohamed Dirani, Christine T. O. Nguyen, Bang V. Bui, Robert Williamson, Jonathan G. Crowston, Peter van Wijngaarden
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a su
Externí odkaz:
https://doaj.org/article/5b0130579595439f8f0a226f8d6265b2