Opposite effects of tissue inhibitor of metalloproteinases-1 (TIMP-1) over-expression and knockdown on colorectal liver metastases

Autor: Bandapalli Obul R, Paul Eva, Schirmacher Peter, Brand Karsten

Publikováno v: BMC Research Notes, Vol 5, Iss 1, p 14 (2012)

Abstract Background Tissue inhibitors of metalloproteinases (TIMPs) and the corresponding metalloproteinases are integral parts of the protease network and have been shown to be involved in cancer development and metastasis. Paradoxically, for TIMP-1

Externí odkaz: https://doaj.org/article/4453f4e439474392a9a460f49f33bfae

MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival

Autor: Wernicke, Caroline M., Richter, Günther H.S., Beinvogl, Beate C., Plehm, Stephanie, Schlitter, Anna M., Bandapalli, Obul R., Prazeres da Costa, Olivia, Hattenhorst, Uwe E., Volkmer, Ines, Staege, Martin S., Esposito, Irene, Burdach, Stefan, Grunewald, Thomas G.P.

Publikováno v: In Leukemia Research September 2012 36(9):1185-1192

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Autor: Went, Molly, Sud, Amit, Försti, Asta, Halvarsson, Britt-Marie, Weinhold, Niels, Kimber, Scott, Van Duin, Mark, Thorleifsson, Gudmar, Holroyd, Amy, Johnson, David C, Li, Ni, Orlando, Giulia, Law, Philip J, Ali, Mina, Chen, Bowang, Mitchell, Jonathan S, Gudbjartsson, Daniel F, Kuiper, Rowan, Stephens, Owen W, Bertsch, Uta, Broderick, Peter, Campo, Chiara, Bandapalli, Obul R, Einsele, Hermann, Gregory, Walter A, Gullberg, Urban, Hillengass, Jens, Hoffmann, Per, Jackson, Graham H, Jöckel, Karl-Heinz, Johnsson, Ellinor, Kristinsson, Sigurður Y, Mellqvist, Ulf-Henrik, Nahi, Hareth, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Nickel, Jolanta, Nöthen, Markus M, Rafnar, Thorunn, Ross, Fiona M, Da Silva Filho, Miguel Inacio, Thomsen, Hauke, Turesson, Ingemar, Vangsted, Annette, Andersen, Niels Frost, Waage, Anders, Walker, Brian A, Wihlborg, Anna-Karin, Broyl, Annemiek, Davies, Faith E, Thorsteinsdottir, Unnur, Langer, Christian, Hansson, Markus, Goldschmidt, Hartmut, Kaiser, Martin, Sonneveld, Pieter, Stefansson, Kari, Morgan, Gareth J, Hemminki, Kari, Nilsson, Björn, Houlston, Richard S, PRACTICAL Consortium

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d79b71242c8d25365962408d9c1611e
https://doaj.org/article/af73d8d01835421aac1fd29b48af6093

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug resistant ALL

Autor: Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Tchinda, Joelle, Dunn, Samuel H, Kunz, Joachim, Richter-Pechanska, Paulina, Marovca, Blerim, Pail, Orrin, Jenni, Silvia, Diaz-Flores, Ernesto, Chang, Bill H, Brown, Timothy J, Collins, Robert H, Uhrig, Sebastian, Balasubramanian, Gnana P, Bandapalli, Obul R, Higi, Salome, Eugster, Sabrina, Voegeli, Pamela, Delorenzi, Mauro, Cario, Gunnar, Loh, Mignon L, Schrappe, Martin, Stanulla, Martin, Kulozik, Andreas E, Muckenthaler, Martina U, Saha, Vaskar, Irving, Julie A, Meisel, Roland, Radimerski, Thomas, Von Stackelberg, Arend, Eckert, Cornelia, Tyner, Jeffrey W, Horvath, Peter, Bornhauser, Beat C, Bourquin, Jean-Pierre

Publikováno v: Frismantas, V, Dobay, M P, Rinaldi, A, Tchinda, J, Dunn, S H, Kunz, J, Richter-Pechanska, P, Marovca, B, Pail, O, Jenni, S, Diaz-Flores, E, Chang, B H, Brown, T J, Collins, R H, Uhrig, S, Balasubramanian, G P, Bandapalli, O R, Higi, S, Eugster, S, Voegeli, P, Delorenzi, M, Cario, G, Loh, M L, Schrappe, M, Stanulla, M, Kulozik, A E, Muckenthaler, M U, Saha, V, Irving, J A, Meisel, R, Radimerski, T, Von Stackelberg, A, Eckert, C, Tyner, J W, Horvath, P, Bornhauser, B C & Bourquin, J-P 2017, ' Ex vivo drug response profiling detects recurrent sensitivity patterns in drug resistant ALL ', Blood, vol. 129, no. 11, pp. e26-e37 . https://doi.org/10.1182/blood-2016-09-738070

Drug sensitivity and resistance testing on diagnostic leukemia samples should provide important functional information to guide actionable target and biomarker discovery. We provide proof of concept data by profiling 60 drugs on 68 acute lymphoblasti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::663a5ec719e7161250bfef6c34a399d6
https://pure.manchester.ac.uk/ws/files/52063353/Manuscript_Frismantas_et_al_rebuttal_final_eBLOOD.pdf

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