Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Bancha Vibulbhan"'
Autor:
Lei Chen, Ling Tong, Joseph A. Kozlowski, Sony Agrawal, Christian L. Holst, Bin Zhong, Yueheng Jiang, Oleg Selyutin, Craig A. Coburn, A. Samuel Vellekoop, Frederick C. Lahser, James I. Fells, Bin Hu, Patricia McMonagle, Donna Carr, Ernest Asante-Appiah, Laura Rokosz, Rong Liu, Gregory Scott Martin, Anilkumar G. Nair, Michael P. Dwyer, Stuart B. Rosenblum, Paul Ingravallo, Michael Wong, Tao Ji, Wensheng Yu, Bancha Vibulbhan, Stephanie Curry, Qingbei Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3793-3799
HCV NS5A inhibitors have demonstrated impressive in vitro virologic profiles in HCV replicon assays and robust HCV RNA titer reduction in the clinic making them attractive components for inclusion in an all oral fixed-dose combination (FDC) regimen f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0f63a0987e007812c5ee3e770f1ad2
https://doi.org/10.1016/j.bmcl.2016.05.042
https://doi.org/10.1016/j.bmcl.2016.05.042
Autor:
Pinto Patrick A, F. George Njoroge, Joseph A. Kozlowski, K.-C. Cheng, Hsueh-Cheng Huang, Frank Bennet, Tin-Yau Chan, Oleg Selyutin, Sony Agrawal, Yuhua Huang, Bancha Vibulbhan, Francisco Velazquez, Stuart B. Rosenblum, Srikanth Venkatraman, Yueheng Jiang, Gopinadhan N. Anilkumar, Cheng Li, Kevin X. Chen, Qingbei Zeng, Charles A. Lesburg, Neng-Yang Shih
Publikováno v:
ACS Medicinal Chemistry Letters. 5:244-248
Starting from indole-based hepatitis C virus (HCV) NS5B polymerase inhibitor lead compound 1, structure modifications were performed at multiple indole substituents to improve potency and pharmacokinetic (PK) properties. Bicyclic quinazolinone was fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d6b7cd7274b7db5b44ce371671e837
https://doi.org/10.1021/ml400192w
https://doi.org/10.1021/ml400192w
Autor:
Stuart B. Rosenblum, Stephen Gavalas, Francisco Velazquez, Pinto Patrick A, Oleg Selyutin, Neng-Yang Shih, Yuhua Huang, Wanli Wu, Sony Agrawal, Yueheng Jiang, Srikanth Venkatraman, Joseph A. Kozlowski, Chuan-kui Jiang, Hsueh-Cheng Huang, Jose S. Duca, Anilkumar G. Nair, Bancha Vibulbhan, Eric Ferrari, Kevin X. Chen, Cheng Li, Charles A. Lesburg, F. George Njoroge, Frank Bennett, Qingbei Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2007-2017
The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many novel enzymatic targets that are potential for development of therapeutic agents. The HCV R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016854d014a0a4d91a3500623598032
https://doi.org/10.1016/j.bmc.2013.01.024
https://doi.org/10.1016/j.bmc.2013.01.024
Autor:
Jun Wang, Weidong Pan, F. George Njoroge, Vinay Girijavallabhan, Ying Huang, Ping Chen, Latha G. Nair, Frank Bennett, Angela Kerekes, Ashok Arasappan, Qun Dang, Qingmei Hong, Stephane L. Bogen, Zhidan Liu, Quang Truong, Sara Esposite, Yuhua Huang, Bancha Vibulbhan, Haiyan Pu, Andrew Stamford, Dmitri A. Pissarnitski, Kevin X. Chen, David B. Olsen, Vishal Verma, David Cole, Zhiqiang Zhao, Randall R. Rossman, Alvarez Carmen S
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 35(6)
Novel 2'-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7-10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2'-olefin. The antiviral effectiveness of the guanosine nucleosides was eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a12e0b1f99db43b830f93b2c1a155d
https://pubmed.ncbi.nlm.nih.gov/27104963
https://pubmed.ncbi.nlm.nih.gov/27104963
Autor:
Oleg Selyutin, F. George Njoroge, Qingbei Zeng, Stuart B. Rosenblum, Joseph A. Kozlowski, Mousumi Sannigrahi, Yueheng Jiang, Frank Bennett, Neng-Yang Shih, Eric Ferrari, Gopinadhan N. Anilkumar, Bancha Vibulbhan, Hsueh-Cheng Huang, Jose S. Duca, Li Wang, Pinto Patrick A, Stephen Gavalas, Haiyan Pu, Sony Agrawal, Kevin X. Chen, Charles A. Lesburg, Yuhua Huang, Tin-Yau Chan, Chuan-kui Jiang, Francisco Velazquez, Srikanth Venkatraman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:713-717
Development of SAR at the C2 position of indole lead 1 , a palm site inhibitor of HCV NS5B polymerase (NS5B IC 50 = 0.053 μM, replicon EC 50 = 4.8 μM), is described. Initial screening identified an acyl sulfonamide moiety as an isostere for the C2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f74a4343432a940d8f437e79028a4cd
https://doi.org/10.1016/j.bmcl.2011.10.041
https://doi.org/10.1016/j.bmcl.2011.10.041
Autor:
Weing Yang, Bancha Vibulbhan, Neng-Yang Shih, Yuhua Huang, Latha G. Nair, Doll Ronald J, Kevin X. Chen, Stephane L. Bogen, F. George Njoroge, Frank Bennett
Publikováno v:
Tetrahedron Letters. 51:3057-3061
The Hepatitis C Virus (HCV) is a major health hazard and its infection is a leading cause of chronic liver disease world wide. In our efforts toward the discovery of a back up to our first clinical candidate, Boceprevir (SCH 503034), we approached th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de2ab61d01e2f715b67efa13cdbe582
https://doi.org/10.1016/j.tetlet.2010.04.010
https://doi.org/10.1016/j.tetlet.2010.04.010
Autor:
Rong Liu, Kuo-Chi Cheng, Kevin X. Chen, Ashok Arasappan, Xiao Tong, Frank Bennett, Edwin Jao, Srikanth Venkatraman, Bancha Vibulbhan, Anil K. Saksena, Stephane L. Bogen, Sumei Ruan, Weidong Pan, Latha G. Nair, Viyyoor M. Girijavallabhan, F. George Njoroge, Zhuyan Guo
Publikováno v:
Journal of Medicinal Chemistry. 52:3679-3688
Hepatitis C is the most prevalent liver disease. Viral hepatitis C (HCV), a small (+)-RNA virus, infects chronically an estimated 300 million people worldwide. Results of Phase I clinical studies with our first generation HCV inhibitor Boceprevir, SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45c54b1cc51e24b97e4ef0f38fe72f0
https://doi.org/10.1021/jm801632a
https://doi.org/10.1021/jm801632a
Autor:
Weidong Pan, Prudence Bradley, Kevin X. Chen, Parekh Tejal N, Andrea Hart, Frank Bennett, Danial Prelusky, Srikanth Venkatraman, Robert Chase, Susan Bogdanowich-Knipp, Jianshe Kong, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Hendrata Siska, Rong Kong, Weiying Yang, Kuo-Chi Cheng, Ashit K. Ganguly, Nancy Butkiewicz, Ashok Arasappan, Yuhua Huang, Andrew Prongay, Bruce A. Malcolm, Xiang Liang, Rong Liu, Xiaoming Cui, Walter A. Korfmacher, Sony Agrawal, Wanli Wu, Zhuyan Guo, Stephane L. Bogen, Pike Russell E, Ronald E. White, Jesse Wong, Yi-Tsung Liu, Jean-Marc Brisson, John Pichardo, Anil K. Saksena, Pavlovsky Anastasia, Bahige M. Baroudy, F. George Njoroge, Vincent Madison, Patrick Pinto, Santhanam Bama, Raymond G. Lovey, Edwin Jao, Lisa Broske, Veljko Popov, Yunsheng Hsieh, Paul Ingravallo, Sumei Ruan, Piwinski John J
Publikováno v:
Journal of Medicinal Chemistry. 49:6074-6086
Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 170 million people worldwide. Currently the only therapeutic regimens are subcutaneous interfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b1025f20fc929de7fcc2e4ce1f01669
https://doi.org/10.1021/jm060325b
https://doi.org/10.1021/jm060325b
Autor:
Kevin X. Chen, John Pichardo, Tze-Ming Chan, Vincent Madison, Andrew Prongay, F. George Njoroge, Bancha Vibulbhan, Alexei V. Buevich
Publikováno v:
Angewandte Chemie International Edition. 44:7024-7028
Macrocyclization through a Mitsunobu reaction was used to synthesize a 17-membered macrocycle. The bicyclic acetal core was prepared completely diastereoselectively. The macrocyclic peptidomimetic surrogate of the P2-P3 dipeptide moiety was designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac387567588076a2b9d7c0882d79da4
https://doi.org/10.1002/anie.200501553
https://doi.org/10.1002/anie.200501553
Autor:
Corey Strickland, Bancha Vibulbhan, Robert Bishop, Xiongwei Shi, Paul Kirschmeier, F. George Njoroge, Amin A. Nomeir, Viyyoor M. Girijavallabhan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5899-5902
Modification of the ethano bridge of the core structure of the antitumor agent, SARASAR® (SCH66336) with concomitant introduction of a sulfonamide moiety off the distal piperidine afforded inhibitor 9-(S-), a compound with greatly improved PK profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2891e40f235fa451c2401adf9fb6b672
https://doi.org/10.1016/j.bmcl.2004.09.020
https://doi.org/10.1016/j.bmcl.2004.09.020