Early Neural and Vascular Dysfunctions in Diabetic Rats Are Largely Sequelae of Increased Sorbitol Oxidation

Autor: Banavara L. Mylari, Peter J. Oates, Charles Kilo, Kathy Chang, Yasudo Ido, Jens R. Nyengaard, Ronald G. Tilton, Joseph R. Williamson

Publikováno v: Ido, Y, Nyengaard, J R, Chang, K, Tilton, R G, Kilo, C, Mylari, B L, Oates, P J & Williamson, J R 2010, ' Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation ', Antioxidants and Redox Signaling, vol. 12, no. 1, pp. 39-51 . https://doi.org/10.1089/ars.2009.2502

These experiments were undertaken to assess the importance of cytoplasmic (c) sorbitol oxidation versus mitochondrial (m) pyruvate oxidation in mediating neural and vascular dysfunction attributable to hyperglycemia in diabetic rats. Increased oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e59cdc21df6315e6634568f3c0a25cf
https://doi.org/10.1089/ars.2009.2502

Aldose reductase inhibitors: therapeutic implications for diabetic complications

Autor: Peter J. Oates, Banavara L. Mylari

Publikováno v: Expert Opinion on Investigational Drugs. 8:2095-2119

The 'late complications' of diabetes mellitus, i.e., nephropathy, neuropathy and retinopathy are firmly rooted in inadequate control of blood glucose: hyperglycaemia. Hyperglycaemia causes elevated cytosolic glucose and/or rates of glucose metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df459f3bfeea4da08cbc730955136f9
https://doi.org/10.1517/13543784.8.12.2095

ChemInform Abstract: 1,2-Dihydro-1-oxopyrrolo(3,2,1-kl)phenothiazine-2-carboxamides and Congeners, Dual Cyclooxygenase/5-Lipoxygenase Inhibitors with Antiinflammatory Activity

Autor: William James Zembrowski, Banavara L. Mylari, Peter F. Moore, Thomas J. Carty

Publikováno v: ChemInform. 22

A series of 1,2-dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine, 1,2-dihydro-1-oxopyrrolo[3,2,1-kl]phenoxazine, and 1,2-dihydro-1-oxopyrrolo[3,2,1-de]acridine-2-carboxamides were prepared by reaction of 1,2-dihydro-1-oxo-pyrrolo[3,2,1-kl]phenothiazine or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5684e8b6b7b595086ff6efae77e79469
https://doi.org/10.1002/chin.199116182

ChemInform Abstract: Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-(1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide

Autor: Michael S. Dina, Nathaniel S. Brackett, Peter J. Oates, James B. Coutcher, William James Zembrowski, Banavara L. Mylari, David A. Beebe

Publikováno v: ChemInform. 32

We report here on our medicinal chemistry and pharmacology efforts to provide a potent sorbitol dehydrogenase inhibitor (SDI) as a tool to probe a recently disclosed hypothesis centered on the role of sorbitol dehydrogenase (SDH) in the second step o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42a97a560394336e88e2157646e4f2fb
https://doi.org/10.1002/chin.200149121

Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain

Autor: Thomas A. Beyer, William James Zembrowski, Todd W. Siegel, Charles E. Aldinger, Michael F. Dee, Pamela J. Scott, Banavara L. Mylari

Publikováno v: Journal of Medicinal Chemistry. 35:457-465

A broad structure-activity program was undertaken in search of effective surrogates for the key benzothiazole side chain of the potent aldose reductase inhibitor, zopolrestat (1). A structure-driven approach was pursued, which spanned exploration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b2684c05d6ddc6fc2c437a60eb0484
https://doi.org/10.1021/jm00081a006