Výsledky vyhledávání

Akademický článek

Metabolic independence drives gut microbial colonization and resilience in health and disease

Publikováno v: Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)

Abstract Background Changes in microbial community composition as a function of human health and disease states have sparked remarkable interest in the human gut microbiome. However, establishing reproducible insights into the determinants of microbi

Externí odkaz: https://doaj.org/article/44bec04531e04bb28a130bfd182cd4c1

Zobrazit plný text záznamu

Akademický článek

Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis

Autor: Omar K. Jamil, Dustin Shaw, Zifeng Deng, Nicholas Dinardi, Natalie Fillman, Shivani Khanna, Noa Krugliak Cleveland, Atsushi Sakuraba, Christopher R. Weber, Russell D. Cohen, Sushila Dalal, Bana Jabri, David T. Rubin, Joel Pekow

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 16 (2023)

Background: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have an increased risk of developing colorectal neoplasia (CRN) in the proximal colon. Objectives: To evaluate whether duration and severity of inflam

Externí odkaz: https://doaj.org/article/3cff1655a86949a1908bb1f1d315efaf

Zobrazit plný text záznamu

Akademický článek

An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease

Autor: Brad A. Palanski, Nielson Weng, Lichao Zhang, Andrew J. Hilmer, Lalla A. Fall, Kavya Swaminathan, Bana Jabri, Carolina Sousa, Nielsen Q. Fernandez-Becker, Chaitan Khosla, Joshua E. Elias

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Gluten peptides from wheat enter the bloodstream and are excreted in urine but are yet to be chemically characterised. Here, the authors show by mass spectrometry that quantitative and qualitative differences in urinary peptides can be detected betwe

Externí odkaz: https://doaj.org/article/fbd7e5f524b5449e9eb03abee53037e8

Zobrazit plný text záznamu

Akademický článek

NK cells contribute to reovirus-induced IFN responses and loss of tolerance to dietary antigen

Autor: Pamela H. Brigleb, Elaine Kouame, Kay L. Fiske, Gwen M. Taylor, Kelly Urbanek, Luzmariel Medina Sanchez, Reinhard Hinterleitner, Bana Jabri, Terence S. Dermody

Publikováno v: JCI Insight, Vol 7, Iss 16 (2022)

Celiac disease is an immune-mediated intestinal disorder that results from loss of oral tolerance (LOT) to dietary gluten. Reovirus elicits inflammatory Th1 cells and suppresses Treg responses to dietary antigen in a strain-dependent manner. Strain t

Externí odkaz: https://doaj.org/article/41f555ddcfee4228a842aa0511f1c5a2

Zobrazit plný text záznamu

Akademický článek

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Sepsis due to multidrug resistant pathogens is the most common cause of death in intensive care units. Here, the authors report that fecal microbiota transplant (FMT) can rescue mice from lethal sepsis of pathogens isolated from stool of a critically

Externí odkaz: https://doaj.org/article/bbaea16a322d4b3d8f09bd8859a8e5d8

Zobrazit plný text záznamu

Akademický článek

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Gluten triggers celiac disease in genetically predisposed individuals, but additional unknown mechanisms are required. Here, the authors show that proteases from Pseudomonas aeruginosa can modulate inflammatory pathways that are relevant to the devel

Externí odkaz: https://doaj.org/article/87da3a2758a84144a45120e2dbe4b18e

Zobrazit plný text záznamu

Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones

Publikováno v: Blood Advances. 7:1910-1914

Clonal hematopoiesis (CH) represents clonal expansion of mutated hematopoietic stem cells detectable in the peripheral blood or bone marrow through next generation sequencing. The current prevailing model posits that CH mutations detected in the peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f281c791cd646c870defc740c8a105d
https://doi.org/10.1182/bloodadvances.2022008521

Zobrazit plný text záznamu

High molecular weight DNA extraction strategies for long‐read sequencing of complex metagenomes

Autor: Alon Shaiber, Luis B. Barreiro, Karen Lolans, Bana Jabri, Hilary G. Morrison, Emily Fogarty, A. Murat Eren, Florian Trigodet

Publikováno v: Molecular Ecology Resources. 22:1786-1802

By offering extremely long contiguous characterization of individual DNA molecules, rapidly emerging long-read sequencing strategies offer comprehensive insights into the organization of genetic information in genomes and metagenomes. However, succes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6af570eb3e5a1b7a18f12f0b6d1b71f
https://doi.org/10.1111/1755-0998.13588

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání