Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Ban-An Khaw"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Cardiac damage associated with iron overload is the most common cause of morbidity and mortality in patients with hereditary hemochromatosis, but the precise mechanisms leading to disease progression are largely unexplored. Here we investiga
Externí odkaz:
https://doaj.org/article/a9a626961b9d43c795e471811889b3af
Autor:
Murui Han, Na Yoon Kim, Ban-An Khaw, Jonghan Kim, Wei Ting Cheng, Archita Venugopal Menon, Prashant Bhattarai
Publikováno v:
Journal of Cardiology and Cardiovascular Sciences. 3:47-54
Publikováno v:
Journal of Drug Targeting. 25:436-450
Drug resistance is a common phenomenon that occurs in cancer chemotherapy. Delivery of chemotherapeutic agents as polymer pro-drug conjugates (PPDCs) pretargeted with bispecific antibodies could circumvent drug resistance in cancer cells. To demonstr
Publikováno v:
Pharmaceutical Research. 34:352-364
LyP-1, a nine-amino-acid tumor homing peptide, selectively binds to its cognate receptor, p32. Overexpression of p32 in certain tumors should allow use of LyP-1 as a targeting agent for the delivery of therapeutic or diagnostic agents. Peptide conjug
Publikováno v:
Current Molecular Imaging. 4:20-28
Publikováno v:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 26(4)
Radiolabeled anti-myosin imaging is well-established for imaging doxorubicin-induced cardiotoxicity. However, to enable imaging of drug-induced cardiotoxicity in small experimental animals, pretargeting with bispecific anti-myosin-anti-DTPA-Fab-Fab
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Cardiac damage associated with iron overload is the most common cause of morbidity and mortality in patients with hereditary hemochromatosis, but the precise mechanisms leading to disease progression are largely unexplored. Here we investigated the e
Autor:
Stan Majewski, Andrew G. Weisenberger, Keyur Gada, Arash Hatefi, Savitri Mandapati, Ban-An Khaw, Vishwesh Patil, Rajiv Panwar
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 41:1603-1616
Doxorubicin, a frontline chemotherapeutic agent, limited by its cardiotoxicity and other tissue toxicities, was conjugated to N-terminal DTPA-modified polyglutamic acid (D-Dox-PGA) to produce polymer pro-drug conjugates. D-Dox-PGA or Tc-99 m labeled
Autor:
Keyur Gada, Yared Tekabe, Rajiv Panwar, Andrew G. Weisenberger, Alexandra D. Varvarigou, Vishwesh Patil, Craig F. Ferris, Stan Majewski, Ban-An Khaw
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 39:824-839
Pretargeting with bispecific monoclonal antibodies (bsMAb) for tumor imaging was developed to enhance target to background activity ratios. Visualization of tumors was achieved by the delivery of mono- and divalent radiolabeled haptens. To improve th
Publikováno v:
Drug Delivery and Translational Research. 2:65-76
The pretargeting approach using bispecific affibody-antibody complex (BAAC) and targeting of chemotherapeutic drug loaded polymers have been used in breast cancer cell cultures to demonstrate targeted chemotherapy and reduce toxicity to non-pretarget