Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial.

Autor: Vincent Meininger, Pierre-François Pradat, Andrea Corse, Safa Al-Sarraj, Benjamin Rix Brooks, James B Caress, Merit Cudkowicz, Stephen J Kolb, Dale Lange, P Nigel Leigh, Thomas Meyer, Stefano Milleri, Karen E Morrison, Richard W Orrell, Gary Peters, Jeffrey D Rothstein, Jeremy Shefner, Arseniy Lavrov, Nicola Williams, Phil Overend, Jeffrey Price, Stewart Bates, Jonathan Bullman, David Krull, Alienor Berges, Bams Abila, Guy Meno-Tetang, Jens Wurthner

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97803 (2014)

The neurite outgrowth inhibitor, Nogo-A, has been shown to be overexpressed in skeletal muscle in amyotrophic lateral sclerosis (ALS); it is both a potential biomarker and therapeutic target. We performed a double-blind, two-part, dose-escalation stu

Externí odkaz: https://doaj.org/article/a10f2b867b174c858f2c458ef8e54388

Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Repeat Doses of GSK249320 in Patients With Stroke

Autor: Monica Simeoni, Bams Abila, Lori A. Enney, Nicola Scott, Steven C. Cramer

Publikováno v: Stroke. 44:1337-1342

Background and Purpose— Restorative therapies have the potential to improve function and reduce disability after stroke with a wide therapeutic window. The current study evaluated GSK249320, a monoclonal antibody that blocks the axon outgrowth inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a8a02460325fce3efd39b85855a39f
https://doi.org/10.1161/strokeaha.111.674366

Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study

Autor: Matt Cleveland, Pierre-François Pradat, Jeffrey D. Rothstein, Stewart Bates, Vincent Meininger, Peter Leigh, Safa Al-Sarraj, Jens Würthner, Bams Abila, Andrea M. Corse, Andrew T. King

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, 2014, 2 (1), pp.165. ⟨10.1186/s40478-014-0165-z⟩
Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2014, 2 (1), pp.165. ⟨10.1186/s40478-014-0165-z⟩

BACKGROUND\ud \ud Amyotrophic lateral sclerosis (ALS) is a primary progressive neurodegenerative disease characterised by neuronal loss of lower motor neurons (in the spinal cord and brainstem) and/or upper motor neurons (in the motor cortex) and sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1312c2052fadcbc197450c31ac044f8c
http://sro.sussex.ac.uk/id/eprint/54197/1/art%3A10.1186%2Fs40478-014-0165-z.pdf