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Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

Autor: Lindstrom, S, Wang, L, Smith, EN, Gordon, W, Vlieg, AV, de Andrade, M, Brody, JA, Pattee, JW, Haessler, J, Brumpton, B, Chasman, DI, Suchon, P, Chen, MH, Turman, C, Germain, M, Wiggins, KL, MacDonald, J, Braekkan, SK, Armasu, SM, Pankratz, N, Jackson, RD, Nielsen, JB, Giulianini, F, Puurunen, MK, Ibrahim, M, Heckbert, SR, Damrauer, SM, Natarajan, P, Klarin, D, de Vries, PS, Sabater-Lleal, M, Huffman, JE, Bammler, TK, Frazer, KA, McCauley, BM, Taylor, K, Pankow, JS, Reiner, AP, Gabrielsen, ME, Deleuze, JF, O'Donnell, CJ, Kim, J, McKnight, B, Kraft, P, Hansen, JB, Rosendaal, FR, Heit, JA, Psaty, BM, Tang, WH, Kooperberg, C, Hveem, K, Ridker, PM, Morange, PE, Johnson, AD, Kabrhel, C, Tregouet, DA, Smith, NL, Busenkell, E, Judy, R, Lynch, J, Levin, M, Aragam, JHK, Chaffin, M, Haas, M, Assimes, TL, Huang, J, Lee, KM, Shao, Q, Huang, YF, Sun, YV, Vujkovic, M, Saleheen, D, Miller, DR, Reaven, P, DuVall, S, Boden, W, Pyarajan, S, Henke, P, Gaziano, JM, Concato, J, Rader, DJ, Cho, K, Chang, KM, Wilson, PWF, Tsao, PS, Kathiresan, S, Obi, A, Million Veteran Program, CHARGE Hemostasis Working Grp, INVENT Consortium

Publikováno v: BLOOD
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To advance our understanding of the biology contributing to VTE, we conducted a genome-wide association study (GWAS) of VTE and a transcriptome-wide association stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::723bb5dc0824ccfc1b9d658b0e3cc42c
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2271

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Amino Acid Differences at Positions 10, 11, and 104 Explain the Profound Catalytic Differences between Two Murine Pi-Class Glutathione S-Transferases

Autor: C R Wolf, Driessen H, Bammler Tk, Finnstrom N

Publikováno v: Biochemistry. 34:9000-9008

The glutathione S-transferases play a pivotal role in the detoxification of toxic and carcinogenic electrophiles. We have previously reported the isolation of two actively transcribed murine pi-class glutathione S-transferase genes. In this study the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68edd3e549a3803504f288bf0b0aa8e3
https://doi.org/10.1021/bi00028a008

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