Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine‐Independent and Chronic Itch.

Autor: Balzulat, Annika¹ (AUTHOR), Zhu, W. Felix² (AUTHOR), Flauaus, Cathrin¹ (AUTHOR), Hernandez‐Olmos, Victor³ (AUTHOR), Heering, Jan³ (AUTHOR), Sethumadhavan, Sunesh⁴ (AUTHOR), Dubiel, Mariam⁵ (AUTHOR), Frank, Annika⁵ (AUTHOR), Menge, Amelie^2,6 (AUTHOR), Hebchen, Maureen¹ (AUTHOR), Metzner, Katharina¹ (AUTHOR), Lu, Ruirui¹ (AUTHOR), Lukowski, Robert⁷ (AUTHOR), Ruth, Peter⁷ (AUTHOR), Knapp, Stefan^2,6 (AUTHOR), Müller, Susanne^2,6 (AUTHOR), Steinhilber, Dieter^2,3 (AUTHOR), Hänelt, Inga⁴ (AUTHOR), Stark, Holger⁵ (AUTHOR), Proschak, Ewgenij^2,3 (AUTHOR) proschak@pharmchem.uni-frankfurt.de

Publikováno v: Advanced Science. 4/17/2024, Vol. 11 Issue 15, p1-15. 15p.

Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons

Autor: Lu, Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui

Publikováno v: Cells; Volume 11; Issue 10; Pages: 1693

The transient receptor potential (TRP) ankyrin type 1 (TRPA1) channel is highly expressed in a subset of sensory neurons where it acts as an essential detector of painful stimuli. However, the mechanisms that control the activity of sensory neurons u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::22f5ff37db30d467343a961cede1b764

The Electronic Belt Fit Test Device - Methodology, Results, and Prospects

Autor: Balzulat, Jochen, Wirsching, Hans-Joachim, Hassan, Joseph E., Noy, Ian, Gardner, William, Shewchenko, Nicholas

Publikováno v: SAE Transactions, 2004 Jan 01. 113, 849-858.

Externí odkaz: https://www.jstor.org/stable/44700008

Functional coupling of Slack channels and P2X3 receptors contributes to neuropathic pain processing

Autor: Lu, Ruirui, Metzner, Katharina, Zhou, Fangyuan, Flauaus, Cathrin, Balzulat, Annika, Engel, Patrick, Petersen, Jonas, Ehinger, Rebekka, Bausch, Anne, Ruth, Peter, Lukowski, Robert, Schmidtko, Achim

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 405, p 405 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1

The sodium-activated potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the sodium-activated potassium current (IKNa) and modulates neuronal activity. Previous studies suggest t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28144eb0463b0090c0db6ab3aa852591
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57481

Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice

Autor: Tilman Gross, Katharina Metzner, Ruirui Lu, Achim Schmidtko, Annika Balzulat, Gesine Wack

Publikováno v: Purinergic Signalling

Previous studies suggest that adenosine A1 receptors (A1R) modulate the processing of pain. The aim of this study was to characterize the distribution of A1R in nociceptive tissues and to evaluate whether targeting A1R with the partial agonist capade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9e3d4c6ad98979c5a21ed754bc1b0
https://pubmed.ncbi.nlm.nih.gov/34313915