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CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function

Autor: Eliana Ruggiero, Erica Carnevale, Aaron Prodeus, Zulma Irene Magnani, Barbara Camisa, Ivan Merelli, Claudia Politano, Lorena Stasi, Alessia Potenza, Beatrice Claudia Cianciotti, Francesco Manfredi, Mattia Di Bono, Luca Vago, Michela Tassara, Sara Mastaglio, Maurilio Ponzoni, Francesca Sanvito, Dai Liu, Ishina Balwani, Rossella Galli, Marco Genua, Renato Ostuni, Matteo Doglio, Daniel O’Connell, Ivy Dutta, Stephanie Ann Yazinski, Mark McKee, Mohamed Simo Arredouani, Birgit Schultes, Fabio Ciceri, Chiara Bonini

Publikováno v: Science translational medicine 14 (2022). doi:10.1126/scitranslmed.abg8027
info:cnr-pdr/source/autori:Ruggiero, Eliana; Carnevale, Erica; Prodeus, Aaron; Magnani, Zulma Irene; Camisa, Barbara; Merelli, Ivan; Politano, Claudia; Stasi, Lorena; Potenza, Alessia; Cianciotti, Beatrice Claudia; Manfredi, Francesco; Di Bono, Mattia; Vago, Luca; Tassara, Michela; Mastaglio, Sara; Ponzoni, Maurilio; Sanvito, Francesca; Liu, Dai; Balwani, Ishina; Galli, Rossella; Genua, Marco; Ostuni, Renato; Doglio, Matteo; O'Connell, Daniel; Dutta, Ivy; Yazinski, Stephanie Ann; McKee, Mark; Arredouani, Mohamed Simo; Schultes, Birgit; Ciceri, Fabio; Bonini, Chiara/titolo:CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function/doi:10.1126%2Fscitranslmed.abg8027/rivista:Science translational medicine/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:14

T cell receptor (TCR)–based therapy has the potential to induce durable clinical responses in patients with cancer by targeting intracellular tumor antigens with high sensitivity and by promoting T cell survival. However, the need for TCRs specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721e152e0f9ed32a72141cc049879e3a
https://pubmed.ncbi.nlm.nih.gov/35138911