Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Balu K Chacko"'
Autor:
Van N. Huynh, Gloria A. Benavides, Michelle S. Johnson, Xiaosen Ouyang, Balu K. Chacko, Edie Osuma, Toni Mueller, John Chatham, Victor M. Darley-Usmar, Jianhua Zhang
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract The accumulation of neurotoxic proteins characteristic of age-related neurodegenerative pathologies such as Alzheimer’s and Parkinson’s diseases is associated with the perturbation of metabolism, bioenergetics, and mitochondrial quality
Externí odkaz:
https://doaj.org/article/68b3c3eb510e4385addb8c4b50678f84
Autor:
Van N Huynh, Sheng Wang, Xiaosen Ouyang, Willayat Y Wani, Michelle S Johnson, Balu K Chacko, Anil G Jegga, Wei-Jun Qian, John C Chatham, Victor M Darley-Usmar, Jianhua Zhang
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
O-linked conjugation of ß-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine residues is a post-translational modification process that senses nutrient availability and cellular stress and regulates diverse biological processes that are involve
Externí odkaz:
https://doaj.org/article/1e1ae2e0cbe84e84ba61486e69e70e74
Autor:
Daniel Fil, Balu K. Chacko, Robbie Conley, Xiaosen Ouyang, Jianhua Zhang, Victor M. Darley-Usmar, Aamir R. Zuberi, Cathleen M. Lutz, Marek Napierala, Jill S. Napierala
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin (FXN). Most FRDA patients are homozygous for large expansions of GAA repeat sequences in intron 1 of FXN
Externí odkaz:
https://doaj.org/article/aa436e951213442a89ae6beaf6e2b59b
Autor:
Kenneth P. Hough, Jennifer L. Trevor, John G. Strenkowski, Yong Wang, Balu K. Chacko, Sultan Tousif, Diptiman Chanda, Chad Steele, Veena B. Antony, Terje Dokland, Xiaosen Ouyang, Jianhua Zhang, Steven R. Duncan, Victor J. Thannickal, Victor M. Darley-Usmar, Jessy S. Deshane
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 54-64 (2018)
Chronic inflammation involving both innate and adaptive immune cells is implicated in the pathogenesis of asthma. Intercellular communication is essential for driving and resolving inflammatory responses in asthma. Emerging studies suggest that extra
Externí odkaz:
https://doaj.org/article/f8e7245e7f7e443e8f97162b871a8929
Autor:
Amanda L. Willig, Philip A. Kramer, Balu K. Chacko, Victor M. Darley-Usmar, Sonya L. Heath, E. Turner Overton
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 648-656 (2017)
Women living with HIV may present with high levels of body fat that are associated with altered bioenergetic function. Excess body fat may therefore exacerbate the bioenergetic dysfunction observed with HIV infection. To determine if body fat is asso
Externí odkaz:
https://doaj.org/article/a146bc0a89d74d31b4df37404a5d85ea
Autor:
Matthew Ryan Smith, Balu K. Chacko, Michelle S. Johnson, Gloria A. Benavides, Karan Uppal, Young-Mi Go, Dean P. Jones, Victor M. Darley-Usmar
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Non-invasive measures of the response of individual patients to cancer therapeutics is an emerging strategy in precision medicine. Platelets offer a potential dynamic marker for metabolism and bioenergetic responses in individual patients since they
Externí odkaz:
https://doaj.org/article/679ee2598f0c41debe34fff32ffaf7d8
Autor:
Balu K. Chacko, Matthew R. Smith, Michelle S. Johnson, Gloria Benavides, Matilda L. Culp, Jyotsna Pilli, Sruti Shiva, Karan Uppal, Young-Mi Go, Dean P. Jones, Victor M. Darley-Usmar
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
Mitochondria possess reserve bioenergetic capacity, supporting protection and resilience in the face of disease. Approaches are limited to understand factors that impact mitochondrial functional reserve in humans. We applied the mitochondrial stress
Externí odkaz:
https://doaj.org/article/b7c283a61e1741bea8cec382c8d2b95d
Autor:
Shaowei Qiu, Vipul S Sheth, Chengcheng Yan, Juan Liu, Balu K. Chacko, Hui Li, David K. Crossman, Seth D. Fortmann, Sajesan Aryal, Ashley Rennhack, Maria B. Grant, Robert S. Welner, Andrew J. Paterson, Adam R. Wende, Victor M. Darley-Usmar, Rui Lu, Jason W. Locasale, Ravi Bhatia
Publikováno v:
Blood Journal.
Tyrosine kinase inhibitors (TKI) are very effective in treating chronic myelogenous leukemia (CML), but primitive, quiescent leukemia stem cells persist as a barrier to cure. We performed a comprehensive evaluation of metabolic adaptation to TKI trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5b2b7f28df7228a8b693ae82067a87a
https://doi.org/10.1182/blood.2022018196
https://doi.org/10.1182/blood.2022018196
Autor:
Margaret B. Bell, Xiaosen Ouyang, Abigail K. Shelton, Nha V. Huynh, Toni Mueller, Balu K. Chacko, Anil G. Jegga, John C. Chatham, C. Ryan Miller, Victor Darley‐Usmar, Jianhua Zhang
Publikováno v:
Journal of Neurochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e40cfa75694ebcc9b131694814d66498
https://doi.org/10.1111/jnc.15835
https://doi.org/10.1111/jnc.15835
Autor:
Balu K. Chacko, Stephanie B. Wall, Philip A. Kramer, Saranya Ravi, Tanecia Mitchell, Michelle S. Johnson, Landon Wilson, Stephen Barnes, Aimee Landar, Victor M. Darley-Usmar
Publikováno v:
Redox Biology, Vol 9, Iss C, Pp 57-66 (2016)
Metabolic control of cellular function is significant in the context of inflammation-induced metabolic dysregulation in immune cells. Generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide are one of the critical events
Externí odkaz:
https://doaj.org/article/fb40ea8e5b29407f8aa0bf4456c53851