Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Balthasar A Heesters"'
Autor:
Onno Kranenburg, Hergen Spits, Julien Villaudy, Madalina Cercel, Miriam Koopman, Cornelis J A Punt, Jamila Laoukili, Andre Verheem, Inne H M Borel Rinkes, Emre Küçükköse, Balthasar A Heesters, Susan van Hal, Sylvia F Boj, Jeanine M L Roodhart
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background The immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint blockade (ICB). However, resistance to ICB is commonly observed, and is associate
Externí odkaz:
https://doaj.org/article/bfcad88f61be41c09cf923011ef6cf7d
Autor:
Balthasar A Heesters, Madelene Lindqvist, Parsia A Vagefi, Eileen P Scully, Frank A Schildberg, Marcus Altfeld, Bruce D Walker, Daniel E Kaufmann, Michael C Carroll
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005285 (2015)
Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact ant
Externí odkaz:
https://doaj.org/article/519d55a5ffb441f49ff22e1e1eb01bdc
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002492 (2012)
The hemagglutinin-esterases (HEs), envelope glycoproteins of corona-, toro- and orthomyxoviruses, mediate reversible virion attachment to O-acetylated sialic acids (O-Ac-Sias). They do so through concerted action of distinct receptor-binding ("lectin
Externí odkaz:
https://doaj.org/article/74eb25750aeb41d0a02f0260c2fac657
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113869- (2024)
Summary: Autoimmune diseases strain healthcare systems worldwide as their incidence rises, and current treatments put patients at risk for infections. An increased understanding of autoimmune diseases is required to develop targeted therapies that do
Externí odkaz:
https://doaj.org/article/bc0022f38fed410292b004f22ca0f71c
Autor:
Ilhan Tomris, Luca Unione, Linh Nguyen, Pouya Zaree, Kim M. Bouwman, Lin Liu, Zeshi Li, Jelle A. Fok, María Ríos Carrasco, Roosmarijn van der Woude, Anne L. M. Kimpel, Mirte W. Linthorst, Sinan E. Kilavuzoglu, Enrico C. J. M. Verpalen, Tom G. Caniels, Rogier W. Sanders, Balthasar A. Heesters, Roland J. Pieters, Jesús Jiménez-Barbero, John S. Klassen, Geert-Jan Boons, Robert P. de Vries
Publikováno v:
ACS chemical biology. American Chemical Society
SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan
Autor:
Joannah R. Fergusson, Michael D. Morgan, Melanie Bruchard, Leonie Huitema, Balthasar A. Heesters, Vincent van Unen, Jan Piet van Hamburg, Nicole N. van der Wel, Daisy Picavet, Frits Koning, Sander W. Tas, Mark S. Anderson, John C. Marioni, Georg A. Holländer, Hergen Spits
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Expression of the Autoimmune regulator (AIRE) outside of the thymus has long been suggested in both humans and mice, but the cellular source in humans has remained undefined. Here we identify AIRE expression in human tonsils and extensively analyzed
Externí odkaz:
https://doaj.org/article/5a82ce720c14415a91015c3f54818c7a
Autor:
W. A. Bemelman, Jochem H. Bernink, Lisette Krabbendam, Christianne J. Buskens, Chantal M. A. Kradolfer, Nienke J. E. Haverkate, Hergen Spits, M Becker, Balthasar A. Heesters
Publikováno v:
Nature communications, 12(1):5841. Nature Publishing Group
Nature Communications, 12(1):5841. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications, 12(1):5841. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, 12(1), 1. Nature Publishing Group
Phenotypic definition of helper ILC1 and NK cells is problematic due to overlapping markers. Recently we showed the identification of cytotoxic ILC3s characterized by expression of CD94. Here we analyse CD127+ ILCs and NK cells in intestinal lamina p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f083059747cc9d7bac97f9593c7a2022
https://pure.amc.nl/en/publications/cd127-cd94-innate-lymphoid-cells-expressing-granulysin-and-perforin-are-expanded-in-patients-with-crohns-disease(b96c4eec-38f0-428b-992c-5963bbe26c6d).html
https://pure.amc.nl/en/publications/cd127-cd94-innate-lymphoid-cells-expressing-granulysin-and-perforin-are-expanded-in-patients-with-crohns-disease(b96c4eec-38f0-428b-992c-5963bbe26c6d).html
Autor:
Maho Nagasawa, Ralph Stadhouders, Suzanne M. Bal, Rudi W. Hendriks, Marjolein J. W. de Bruijn, Chantal M. A. Kradolfer, Lisette Krabbendam, Itziar Martinez-Gonzalez, Hergen Spits, Balthasar A. Heesters, Korneliusz Golebski
Publikováno v:
Journal of Experimental Medicine, 216(8), 1762-+. Rockefeller University Press
Journal of experimental medicine, 216(8), 1762-1776. Rockefeller University Press
The Journal of Experimental Medicine
Journal of experimental medicine, 216(8), 1762-1776. Rockefeller University Press
The Journal of Experimental Medicine
The human CD117+ CRTH2− ILC population contains ILC precursors. Nagasawa et al. segregate this population by the mutually exclusive expression of KLRG1 and NKp46. KLRG1+ ILCs are biased toward the ILC2 lineage, whereas NKp46 clearly defines ILC3-li
Autor:
Mongkol Lao-araya, Stephen R. Durham, Oliver Hunewald, Anke-Hilse Maitland-van der Zee, Balthasar A. Heesters, Janice A. Layhadi, Gemma Vilà-Nadal, Korneliusz Golebski, Esther H. Steveling-Klein, Mohamed H. Shamji, Rachael C.Y. Li, Suzanne M. Bal, Wytske Fokkens, Cornelis M. van Drunen, Feng He, Umit Murat Sahiner, Susanne J. H. Vijverberg, Markus Ollert, Oleksandra Fedina, Madison M. Lenormand, Hergen Spits, Guillem Montamat
Publikováno v:
Immunity, 54(2), 291-307.e7. Cell Press
Immunity, 54(2), 291. Cell Press
307.e7
Golebski, K, Layhadi, J A, Sahiner, U, Steveling-Klein, E H, Lenormand, M M, Li, R C Y, Bal, S M, Heesters, B A, Vilà-Nadal, G, Hunewald, O, Montamat, G, He, F Q, Ollert, M, Fedina, O, Lao-Araya, M, Vijverberg, S J H, Maitland-van der Zee, A H, van Drunen, C M, Fokkens, W J, Durham, S R, Spits, H & Shamji, M H 2021, ' Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response ', Immunity, vol. 54, no. 2, pp. 291-307.e7 . https://doi.org/10.1016/j.immuni.2020.12.013
Immunity, 54(2), 291. Cell Press
307.e7
Golebski, K, Layhadi, J A, Sahiner, U, Steveling-Klein, E H, Lenormand, M M, Li, R C Y, Bal, S M, Heesters, B A, Vilà-Nadal, G, Hunewald, O, Montamat, G, He, F Q, Ollert, M, Fedina, O, Lao-Araya, M, Vijverberg, S J H, Maitland-van der Zee, A H, van Drunen, C M, Fokkens, W J, Durham, S R, Spits, H & Shamji, M H 2021, ' Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response ', Immunity, vol. 54, no. 2, pp. 291-307.e7 . https://doi.org/10.1016/j.immuni.2020.12.013
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 innate lymphoid cells (IL-10+ ILC2s) in modulating grass-pollen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622c6c31bcc0f5cbd5b2bdf9848d4676
https://pure.amc.nl/en/publications/induction-of-il10producing-type-2-innate-lymphoid-cells-by-allergen-immunotherapy-is-associated-with-clinical-response(229380d1-a168-41ca-a2cf-67cf7a6c8968).html
https://pure.amc.nl/en/publications/induction-of-il10producing-type-2-innate-lymphoid-cells-by-allergen-immunotherapy-is-associated-with-clinical-response(229380d1-a168-41ca-a2cf-67cf7a6c8968).html
Autor:
Geertje M. de Boer, Joannah R. Fergusson, Balthasar A. Heesters, Menno van Nimwegen, Gert-Jan Braunstahl, Gerdien A. Tramper-Stranders, Chantal M. A. Kradolfer, A. Paul Nagtegaal, Wilfred F. J. van IJcken, Wytske Fokkens, Danny Huylebroeck, Korneliusz Golebski, Itziar Martinez-Gonzalez, Esmee K. van der Ploeg, Sophie van Tol, Suzanne M. Bal, Brendon P. Scicluna, Rudi W. Hendriks, Cornelis M. van Drunen, Hergen Spits, Marjolein J. W. de Bruijn, Ralph Stadhouders
Publikováno v:
Science immunology, 6(55), 1. American Association for the Advancement of Science
Science immunology, 6(55):eabd3489. American Association for the Advancement of Science
Science immunology, 6(55):eabd3489. American Association for the Advancement of Science
Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s (iILC2s) were identified as a major source of type 2 cytokines. The human