Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.

Autor: Brunner AM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Blonquist TM; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., DeAngelo DJ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., McMasters M; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Fell G; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Hermance NM; Department of Biology, Worcester Polytechnic Institute, Worcester, MA, USA., Winer ES; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Lindsley RC; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Hobbs GS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Amrein PC; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Hock HR; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Steensma DP; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Garcia JS; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Luskin MR; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Stone RM; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Ballen KK; Division of Hematology-Oncology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA., Rosenblatt J; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Avigan D; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Nahas MR; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Mendez LM; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., McAfee SL; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Moran JA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Bergeron M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Foster J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Bertoli C; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Manning AL; Department of Biology, Worcester Polytechnic Institute, Worcester, MA, USA., McGregor KL; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Fishman KM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Kuo FC; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Baltay MT; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Macrae M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Burke M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Behnan T; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Wey MC; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Som TT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Ramos AY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Rae J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Lombardi Story J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Nelson N; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Logan E; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Connolly C; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Neuberg DS; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Chen YB; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Graubert TA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Fathi AT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. Electronic address: afathi@partners.org.

Publikováno v: The Lancet. Haematology [Lancet Haematol] 2020 Feb; Vol. 7 (2), pp. e122-e133. Date of Electronic Publication: 2019 Dec 11.