Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Baltasar Lucendo"'
Publikováno v:
Cells, Vol 13, Iss 18, p 1594 (2024)
To accurately study human organ function and disease ‘in the dish’, it is necessary to develop reliable cell-based models that closely track human physiology. Our interest lay with the liver, which is the largest solid organ in the body. The live
Externí odkaz:
https://doaj.org/article/0462fd83545e40cb9ad3d4ac00b00098
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Amanda J. Drake, David C. Hay
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100493- (2021)
Summary: This protocol describes the production of hepatocyte-like cells (HLCs) from human pluripotent stem cells and how to induce hepatic steatosis, a condition characterized by intracellular lipid accumulation. Following differentiation to an HLC
Externí odkaz:
https://doaj.org/article/8d13b0dc3bd7402bb841e0635d89763b
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100502- (2021)
Summary: This protocol describes how to produce human liver spheres from pluripotent stem cell-derived hepatic progenitors, endothelial cells, and hepatic stellate cells. Liver spheres form by self-assembly in microwells, generating up to 73 spheres
Externí odkaz:
https://doaj.org/article/c545e9cb181540ee87b21a9245f16b38
Autor:
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552- (2021)
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In
Externí odkaz:
https://doaj.org/article/0fd0f2e5fb724e438758d7df1a29d1bc
Autor:
Yu Wang, Michael H. Tatham, Wolfgang Schmidt-Heck, Carolyn Swann, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Tilo Kunath, Timothy R. Rudd, Andrew J.H. Smith, Jan G. Hengstler, Patricio Godoy, Ronald T. Hay, David C. Hay
Publikováno v:
iScience, Vol 16, Iss , Pp 206-217 (2019)
Summary: During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor signaling network is known to be essential for hepatocyte specification and maint
Externí odkaz:
https://doaj.org/article/4a91a3c282f3471bad0373765ad436f8
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Sara Wernig-Zorc, John P. Thomson, Roderick N. Carter, Marcus J. Lyall, Paul D. Walker, Alpesh Thakker, Richard R. Meehan, Gareth G. Lavery, Nicholas M. Morton, Christian Ludwig, Daniel A. Tennant, David C. Hay, Amanda J. Drake
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101931- (2021)
Summary: Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, b
Externí odkaz:
https://doaj.org/article/231ee5e1aa334f8c91d6ea963c63a1fc
Autor:
Joseph A Leedale, Baltasar Lucendo-Villarin, Jose Meseguer-Ripolles, Alvile Kasarinaite, Steven D Webb, David C Hay
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0244070 (2021)
A major bottleneck in the study of human liver physiology is the provision of stable liver tissue in sufficient quantity. As a result, current approaches to modelling human drug efficacy and toxicity rely heavily on immortalized human and animal cell
Externí odkaz:
https://doaj.org/article/f606f79e86c84e768d428358c04cb832
Autor:
Marco Romano, Raul Elgueta, Daniel McCluskey, Ana Maria Ortega-Prieto, Emilie Stolarczyk, Francesco Dazzi, Baltasar Lucendo-Villarin, Jose Meseguer-Ripolles, James Williams, Giorgia Fanelli, David C. Hay, Fiona M. Watt, Giovanna Lombardi
Publikováno v:
Cells, Vol 11, Iss 1, p 24 (2021)
Regenerative medicine aims to replace damaged tissues by stimulating endogenous tissue repair or by transplanting autologous or allogeneic cells. Due to their capacity to produce unlimited numbers of cells of a given cell type, pluripotent stem cells
Externí odkaz:
https://doaj.org/article/4bc8b73c5c6f4a5aadacfd862fdb872e
Autor:
Dagmara Szkolnicka, Baltasar Lucendo-Villarin, Joanna K. Moore, Kenneth J. Simpson, Stuart J. Forbes, David C. Hay
Publikováno v:
Stem Cells Translational Medicine, Vol 5, Iss 6, Pp 764-772 (2016)
The liver performs multiple functions within the human body. It is composed of numerous cell types, which play important roles in organ physiology. Our study centers on the major metabolic cell type of the liver, the hepatocyte, and its susceptibilit
Externí odkaz:
https://doaj.org/article/fd4ea218b69242f5ae47142ac9283f78
Autor:
Kate Cameron, Rosanne Tan, Wolfgang Schmidt-Heck, Gisela Campos, Marcus J. Lyall, Yu Wang, Baltasar Lucendo-Villarin, Dagmara Szkolnicka, Nicola Bates, Susan J. Kimber, Jan G. Hengstler, Patricio Godoy, Stuart J. Forbes, David C. Hay
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1250-1262 (2015)
Stem cell-derived somatic cells represent an unlimited resource for basic and translational science. Although promising, there are significant hurdles that must be overcome. Our focus is on the generation of the major cell type of the human liver, th
Externí odkaz:
https://doaj.org/article/c136c73166554653a8456549bcaa5da3