The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

Autor: Reed, AD, Fletcher, JR, Huang, YY, Thanissery, R, Rivera, AJ, Parsons, RJ, Stewart, AK, Kountz, DJ, Shen, A, Balskus, EP, Theriot, CM

Publikováno v: mSphere, vol 7, iss 2

An intact gut microbiota confers colonization resistance against Clostridioides difficile through a variety of mechanisms, likely including competition for nutrients. Recently, proline was identified as an important environmental amino acid that C. d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::458c1692c01406462d2a3fcd7e98bc21
https://escholarship.org/uc/item/8q03n34s

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Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme.

Autor: Bae M; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Le C; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Mehta RS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Dong X; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Pieper LM; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA., Ramirez L; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA., Alexander M; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA., Kiamehr S; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Turnbaugh PJ; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub-San Francisco, San Francisco, CA 94158, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Chan AT; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: balskus@chemistry.harvard.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 Nov 13; Vol. 32 (11), pp. 1887-1896.e8. Date of Electronic Publication: 2024 Oct 28.