Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Balram Chowbay"'
Autor:
Yuan Chen, Li Zhang, Xingjie Wu, Xuecheng Sun, Noah R. Sundah, Chi Yan Wong, Auginia Natalia, John K. C. Tam, Darren Wan-Teck Lim, Balram Chowbay, Beng Ti Ang, Carol Tang, Tze Ping Loh, Huilin Shao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Conventional magnetic biosensing technologies have reduced analytical capacity for magnetic field dimensionality and require extensive sample processing. To address these challenges, we spatially engineer 3D magnetic response gradients for d
Externí odkaz:
https://doaj.org/article/1205fa90508243ea8bd82a8fd32f8525
Autor:
Sry Suryani Widjaja, Muhammad Ichwan, Balram Chowbay, Rusdiana, Tengku Helvi Mardani, Vito Filbert Jayalie
Publikováno v:
Journal of Advanced Pharmaceutical Technology & Research, Vol 15, Iss 3, Pp 135-138 (2024)
Acute pain, moderate-to-severe cancer pain, and persistent malignant pain are all frequently treated with opioids. It is regarded as one of the main tenets of analgesic treatment. The relationship between human opioid sensitivity and genetic polymorp
Externí odkaz:
https://doaj.org/article/68731e15029e4ab9a654ad9816802b32
Autor:
Jia Qi Yeo, Hua Heng McVin Cheen, Amanda Wong, Teong Guan Lim, Balram Chowbay, Wai Fook Leong, Chunyan Wang, Ennaliza Salazar, Webber Pak Wo Chan, San Choon Kong, Wan Chee Ong
Publikováno v:
JGH Open, Vol 6, Iss 10, Pp 658-666 (2022)
Abstract Background and Aim Thiopurines are recommended for maintenance of steroid‐free remission (SFR) in inflammatory bowel disease (IBD). Thiopurine metabolite monitoring (MM) is increasingly used in the West but remains novel in Singapore, with
Externí odkaz:
https://doaj.org/article/47148295f99f4b6f8d27e10997ba6d8e
Autor:
Srinivasaraghavan Kannan, Mohan R. Pradhan, Garima Tiwari, Wei-Chong Tan, Balram Chowbay, Eng Huat Tan, Daniel Shao-Weng Tan, Chandra Verma
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Small molecules targeting the EGFR tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced AT
Externí odkaz:
https://doaj.org/article/145a6170f8624c79b228e5d534e4ff3b
Autor:
Werner Schroth, Stefan Winter, Thomas Mürdter, Elke Schaeffeler, Diana Eccles, Bryony Eccles, Balram Chowbay, Chiea C. Khor, Arafat Tfayli, Nathalie K. Zgheib, Michel Eichelbaum, Matthias Schwab, Hiltrud Brauch
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Purpose: Prediction of impaired tamoxifen (TAM) to endoxifen metabolism may be relevant to improve breast cancer treatment, e.g., via TAM dose increase. The polymorphic cytochrome P450 2D6 (CYP2D6) strongly determines an individual’s capacity for e
Externí odkaz:
https://doaj.org/article/88e85bdd41744421ab1879bce1e36e3e
Autor:
Natalia Sutiman, Zhenxian Zhang, Eng Huat Tan, Mei Kim Ang, Shao-Weng Daniel Tan, Chee Keong Toh, Quan Sing Ng, Balram Chowbay, Wan-Teck Lim
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154316 (2016)
PURPOSE:This study aimed to evaluate the safety, tolerability and pharmacokinetics of the combination of oral vinorelbine with erlotinib using the conventional (CSV) and metronomic (MSV) dosing schedules in patients with advanced non-small cell lung
Externí odkaz:
https://doaj.org/article/150bd87ff00e4b54bbb6e78a4be7f732
Autor:
Amit Jain, Cindy Lim, Eugene MingJin Gan, David Zhihao Ng, Quan Sing Ng, Mei Kim Ang, Angela Takano, Kian Sing Chan, Wu Meng Tan, Ravindran Kanesvaran, Chee Keong Toh, Chian Min Loo, Anne Ann Ling Hsu, Anantham Devanand, Chong Hee Lim, Heng Nung Koong, Tina Koh, Kam Weng Fong, Swee Peng Yap, Su Woon Kim, Balram Chowbay, Lynette Oon, Kiat Hon Lim, Wan Teck Lim, Eng Huat Tan, Daniel Shao Weng Tan
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123587 (2015)
OBJECTIVES:This purpose of this study was to examine clinical-pathologic factors--particularly smoking and brain metastases--in EGFR mutation positive (M(+)) lung adenocarcinoma (ADC) to determine their impact on survival in patients treated with fir
Externí odkaz:
https://doaj.org/article/e38914ce431946da8fb3542b41f8e3e6
Autor:
Ying-Hsia Chu, Huihua Li, Hui Shan Tan, Valerie Koh, Johnathan Lai, Wai Min Phyo, Yukti Choudhury, Ravindran Kanesvaran, Noan Minh Chau, Chee Keong Toh, Quan Sing Ng, Puay Hoon Tan, Balram Chowbay, Min-Han Tan
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134102 (2015)
Sunitinib is a tyrosine kinase inhibitor used as first-line treatment for metastatic renal cell carcinoma (mRCC). Asian ethnicity has been previously associated with lower clearance and greater toxicities for sunitinib treatment, relative to Caucasia
Externí odkaz:
https://doaj.org/article/cd634b220cf4462281ea4d347fd436a1
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51771 (2012)
OBJECTIVE: This study aimed to explore the influence of SLC22A1, PXR, ABCG2, ABCB1 and CYP3A5 3 genetic polymorphisms on imatinib mesylate (IM) pharmacokinetics in Asian patients with chronic myeloid leukemia (CML). PATIENTS AND METHODS: Healthy subj
Externí odkaz:
https://doaj.org/article/a357ff9774bb4f5aa8a485f1ae669fa9
Autor:
Ramasamy Saminathan, Jing Bai, Laleh Sadrolodabaee, Govindasamy Muralidharan Karthik, Onkar Singh, Koilan Subramaniyan, Chi Bun Ching, Wei Ning Chen, Balram Chowbay
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15064 (2010)
Recognizing specific protein changes in response to drug administration in humans has the potential for the development of personalized medicine. Such changes can be identified by pharmacoproteomics approach based on proteomic technologies. It can al
Externí odkaz:
https://doaj.org/article/a9c4aecc000e4702b70c8b459fcd3495