Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Balraj Doray"'
Autor:
Debajit Dey, Enya Qing, Yanan He, Yihong Chen, Benjamin Jennings, Whitaker Cohn, Suruchi Singh, Lokesh Gakhar, Nicholas J. Schnicker, Brian G. Pierce, Julian P. Whitelegge, Balraj Doray, John Orban, Tom Gallagher, S. Saif Hasan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The spike (S) protein of SARS-CoV-2 is delivered to the virion assembly site in the ER-Golgi Intermediate Compartment (ERGIC) from both the ER and cis-Golgi in infected cells. However, the relevance and modulatory mechanism of this bidirecti
Externí odkaz:
https://doaj.org/article/f85c779209414774853f75b4271ccf93
Autor:
Amanda Heard, Jack H. Landmann, Ava R. Hansen, Alkmini Papadopolou, Yu-Sung Hsu, Mehmet Emrah Selli, John M. Warrington, John Lattin, Jufang Chang, Helen Ha, Martina Haug-Kroeper, Balraj Doray, Saar Gill, Marco Ruella, Katharina E. Hayer, Matthew D. Weitzman, Abby M. Green, Regina Fluhrer, Nathan Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Loss of surface CD19 expression by leukemic cells leads to resistance and relapse to CD19-targeted CAR-T therapies. Here the authors show that loss of SPPL3 in malignant B cells results in hyperglycosylation of CD19.
Externí odkaz:
https://doaj.org/article/0f7c94a068e44180b9af36e2164d17d4
Autor:
Lin Liu, Balraj Doray
Publikováno v:
FEBS Open Bio, Vol 11, Iss 6, Pp 1695-1703 (2021)
Disruption of the mannose 6‐phosphate (M‐6‐P) pathway in HeLa cells by inactivation of the GNPTAB gene, which encodes the α/β subunits of GlcNAc‐1‐phosphotransferase, results in missorting of newly synthesized lysosomal acid hydrolases to
Externí odkaz:
https://doaj.org/article/60f53cf7d2a14ff799b692e90ddad760
Publikováno v:
FEBS Open Bio, Vol 11, Iss 2, Pp 367-374 (2021)
The Golgi‐localized, gamma‐ear containing, ADP‐ribosylation factor‐binding proteins (GGAs 1, 2, and 3) are multidomain proteins that bind mannose 6‐phosphate receptors (MPRs) at the Golgi and play a role, along with adaptor protein complex
Externí odkaz:
https://doaj.org/article/2e7303a512364d849821ba9848d2950a
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 59-65 (2017)
Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficien
Externí odkaz:
https://doaj.org/article/dc91b3923aad4519820ea86aae611fa8
Autor:
Perunthottathu K Umasankar, Li Ma, James R Thieman, Anupma Jha, Balraj Doray, Simon C Watkins, Linton M Traub
Publikováno v:
eLife, Vol 3 (2014)
Clathrin-mediated endocytosis is an evolutionarily ancient membrane transport system regulating cellular receptivity and responsiveness. Plasmalemma clathrin-coated structures range from unitary domed assemblies to expansive planar constructions with
Externí odkaz:
https://doaj.org/article/817fa4d39eda4a23bfab868214a4f529
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30184 (2012)
Numerous studies using cultured mammalian cells have shown that the three GGAs (Golgi-localized, gamma-ear containing, ADP-ribosylation factor- binding proteins) function in the transport of cargo proteins between the trans- Golgi network and endosom
Externí odkaz:
https://doaj.org/article/8b7cec6590c84d559fa51f27c2b71476
Autor:
Debajit Dey, Enya Qing, Yanan He, Yihong Chen, Benjamin Jennings, Whitaker Cohn, Suruchi Singh, Lokesh Gakhar, Nicholas J. Schnicker, Brian G. Pierce, Julian P. Whitelegge, Balraj Doray, John P. Orban, Tom Gallagher, S. Saif Hasan
The spike (S) protein of SARS-CoV-2 is delivered to the virion assembly site in the ER-Golgi Intermediate Compartment (ERGIC) from both the ER and cis-Golgi in infected cells1-3. However, the relevance and modulatory mechanism of this bidirectional t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::990c3f296f76b00867bdd9768fb41706
https://doi.org/10.1101/2023.03.09.531992
https://doi.org/10.1101/2023.03.09.531992
Autor:
Hua Li, Wang-Sik Lee, Xiang Feng, Lin Bai, Benjamin C. Jennings, Lin Liu, Balraj Doray, William M. Canfield, Stuart Kornfeld, Huilin Li
Publikováno v:
Nat Struct Mol Biol
Vertebrates utilize the mannose 6-phosphate (M6P) recognition system to deliver lysosomal hydrolases to lysosomes. Key to this pathway is GlcNAc-1-phosphotransferase (PTase) that selectively adds GlcNAc-P to mannose residues of the hydrolases. Human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce4b705e21d24778d09b230fa7ba79a
https://doi.org/10.1038/s41594-022-00748-0
https://doi.org/10.1038/s41594-022-00748-0
Autor:
Balraj Doray, Lin Liu
Publikováno v:
FEBS Open Bio, Vol 11, Iss 6, Pp 1695-1703 (2021)
FEBS Open Bio
FEBS Open Bio
Disruption of the mannose 6‐phosphate (M‐6‐P) pathway in HeLa cells by inactivation of the GNPTAB gene, which encodes the α/β subunits of GlcNAc‐1‐phosphotransferase, results in missorting of newly synthesized lysosomal acid hydrolases to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af469f9cf6cac140f558ad11501eff4
https://doaj.org/article/60f53cf7d2a14ff799b692e90ddad760
https://doaj.org/article/60f53cf7d2a14ff799b692e90ddad760