Synthesis and screening of a library of Lewis^x deoxyfluoro-analogues reveals differential recognition by glycan-binding partners.

Autor: Hollingsworth, Kristian, Di Maio, Antonio, Richards, Sarah-Jane, Vendeville, Jean-Baptiste, Wheatley, David E., Council, Claire E., Keenan, Tessa, Ledru, Hélène, Chidwick, Harriet, Huang, Kun, Parmeggiani, Fabio, Marchesi, Andrea, Chai, Wengang, McBerney, Ryan, Kamiński, Tomasz P., Balmforth, Matthew R., Tamasanu, Alexandra, Finnigan, James D., Young, Carl, Warriner, Stuart L.

Publikováno v: Nature Communications; 9/14/2024, Vol. 15 Issue 1, p1-14, 14p

Piggybacking on the Cholera Toxin: Identification of a Toxoid-binding Protein as an Approach for Targeted Delivery of Proteins to Motor Neurons

Autor: Balmforth, Matthew R, Haigh, Jessica, Tiede, Christian, Tomlinson, Darren C, Deuchars, Jim, Webb, Michael E, Turnbull, W Bruce

A significant unmet need exists for the delivery of biologic drugs such as polypeptides or nucleic acids, to the central nervous system (CNS) for the treatment and understanding of neurodegenerative diseases. Naturally occurring toxoids have been con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd00d3eef17877b1ebace49696ae7766
https://doi.org/10.1101/2020.05.11.982132

Synthesis and screening of a library of Lewis ^x deoxyfluoro-analogues reveals differential recognition by glycan-binding partners.

Autor: Hollingsworth K; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Di Maio A; Glycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Richards SJ; Department of Chemistry, University of Warwick, Coventry, UK.; Manchester Institute of Biotechnology (MIB), Department of Chemistry, University of Manchester, Manchester, UK., Vendeville JB; School of Chemistry, University of Southampton, Highfield, Southampton, UK., Wheatley DE; School of Chemistry, University of Southampton, Highfield, Southampton, UK., Council CE; School of Chemistry, University of Southampton, Highfield, Southampton, UK., Keenan T; Department of Chemistry, University of York, Heslington, York, UK., Ledru H; School of Chemistry, Cantock's Close, University of Bristol, Bristol, UK., Chidwick H; Department of Chemistry, University of York, Heslington, York, UK., Huang K; Manchester Institute of Biotechnology (MIB), Department of Chemistry, University of Manchester, Manchester, UK., Parmeggiani F; Manchester Institute of Biotechnology (MIB), Department of Chemistry, University of Manchester, Manchester, UK., Marchesi A; Manchester Institute of Biotechnology (MIB), Department of Chemistry, University of Manchester, Manchester, UK., Chai W; Glycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., McBerney R; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Kamiński TP; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Balmforth MR; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Tamasanu A; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Finnigan JD; Prozomix Limited, Haltwhistle Industrial Estate, Haltwhistle, Northumberland, UK., Young C; Prozomix Limited, Haltwhistle Industrial Estate, Haltwhistle, Northumberland, UK., Warriner SL; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Webb ME; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Fascione MA; Department of Chemistry, University of York, Heslington, York, UK., Flitsch S; Manchester Institute of Biotechnology (MIB), Department of Chemistry, University of Manchester, Manchester, UK., Galan MC; School of Chemistry, Cantock's Close, University of Bristol, Bristol, UK., Feizi T; Glycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. t.feizi@imperial.ac.uk., Gibson MI; Department of Chemistry, University of Warwick, Coventry, UK. matt.gibson@manchester.ac.uk.; Manchester Institute of Biotechnology (MIB), Department of Chemistry, University of Manchester, Manchester, UK. matt.gibson@manchester.ac.uk.; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK. matt.gibson@manchester.ac.uk., Liu Y; Glycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. yan.liu2@imperial.ac.uk., Turnbull WB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. W.B.Turnbull@leeds.ac.uk., Linclau B; School of Chemistry, University of Southampton, Highfield, Southampton, UK. bruno.linclau@ugent.be.; Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium. bruno.linclau@ugent.be.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 13; Vol. 15 (1), pp. 7925. Date of Electronic Publication: 2024 Sep 13.