Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.

Autor: Weiss SA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA., Huang AY; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Fung ME; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Martinez D; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Chen ACY; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., LaSalle TJ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Miller BC; Department of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Scharer CD; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., Hegde M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Nguyen TH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Rowe JH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Osborn JF; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Patterson DG; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Sifnugel N; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Mei-An Nolan C; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Davidson RA; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Schwartz MA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Bally APR; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., Neeld DK; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., LaFleur MW; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Boss JM; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, USA., Doench JG; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Nicholas Haining W; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; ArsenalBio, San Francisco, CA, USA., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. arlene_sharpe@hms.harvard.edu.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. arlene_sharpe@hms.harvard.edu., Sen DR; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. dsen@mgh.harvard.edu.; Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. dsen@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. dsen@mgh.harvard.edu.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. dsen@mgh.harvard.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Oct; Vol. 25 (10), pp. 1871-1883. Date of Electronic Publication: 2024 Sep 17.

IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells.

Autor: Powell MD; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Lu P; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Neeld DK; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Kania AK; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., George-Alexander LMM; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Bally APR; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Scharer CD; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Boss JM; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.

Publikováno v: ImmunoHorizons [Immunohorizons] 2022 Dec 01; Vol. 6 (12), pp. 872-882.

PD-1 Expression during Acute Infection Is Repressed through an LSD1-Blimp-1 Axis.

Autor: Bally APR; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Neeld DK; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Lu P; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Majumder P; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Tang Y; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Barwick BG; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Wang Q; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322., Boss JM; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322; and jmboss@emory.edu.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322 jmboss@emory.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Jan 15; Vol. 204 (2), pp. 449-458. Date of Electronic Publication: 2019 Dec 06.

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.

Autor: Scharer CD; Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA. cdschar@emory.edu., Barwick BG; Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA.; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, 30322, USA., Guo M; Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA.; Xiangya School of Medicine, Central South University, Changsha, Hunan, 410008, China., Bally APR; Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA., Boss JM; Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA. jmboss@emory.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Apr 27; Vol. 9 (1), pp. 1698. Date of Electronic Publication: 2018 Apr 27.