Safety and efficacy of novel malaria vaccine regimens of RTS, S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP

Autor: Rampling, T, Ewer, KJ, Bowyer, G, Edwards, NJ, Wright, D, Sridhar, S, Payne, R, Powlson, J, Bliss, C, Venkatraman, N, Poulton, ID, De Graaf, H, Gbesemete, D, Grobbelaar, A, Davies, H, Roberts, R, Angus, B, Ivinson, K, Weltzin, R, Rajkumar, B-Y, Wille-Reece, U, Lee, C, Ockenhouse, C, Sinden, R, Gerry, SC, Lawrie, A, Vekemans, J, Morelle, D, Lievens, M, Ballou, RW, Lewis, DJM, Cooke, GS, Faust, SN, Hill, AV

We assessed a combination multi-stage malaria vaccine schedule in which RTS,S/AS01B was given concomitantly with viral vectors expressing multiple-epitope thrombospondin-related adhesion protein (ME-TRAP) in a 0-month, 1-month, and 2-month schedule.

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http://hdl.handle.net/10044/1/64182

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Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP.

Autor: Rampling T; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Ewer KJ; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Bowyer G; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Edwards NJ; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Wright D; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Sridhar S; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Payne R; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Powlson J; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Bliss C; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Venkatraman N; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Poulton ID; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., de Graaf H; 2NIHR Wellcome Trust Clinical Research Facility, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Gbesemete D; 2NIHR Wellcome Trust Clinical Research Facility, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Grobbelaar A; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Davies H; 3Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697 USA., Roberts R; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Angus B; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Ivinson K; PATH Malaria Vaccine Initiative, Washington, DC USA., Weltzin R; PATH Malaria Vaccine Initiative, Washington, DC USA., Rajkumar BY; PATH Malaria Vaccine Initiative, Washington, DC USA., Wille-Reece U; PATH Malaria Vaccine Initiative, Washington, DC USA., Lee C; PATH Malaria Vaccine Initiative, Washington, DC USA., Ockenhouse C; PATH Malaria Vaccine Initiative, Washington, DC USA., Sinden RE; 5Department of Life Sciences, Imperial College London, London, UK., Gerry SC; 6Centre for Statistics in Medicine, University of Oxford, Oxford, UK., Lawrie AM; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Vekemans J; GSK Vaccines, Rixensart, Belgium., Morelle D; GSK Vaccines, Rixensart, Belgium., Lievens M; GSK Vaccines, Rixensart, Belgium., Ballou RW; GSK Vaccines, Rixensart, Belgium., Lewis DJM; 8Clinical Research Centre, University of Surrey, Guildford, GU2 7XP UK., Cooke GS; 9Infectious Diseases Section, Faculty of Medicine, Department of Medicine, Imperial College London, London, UK., Faust SN; 2NIHR Wellcome Trust Clinical Research Facility, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Gilbert S; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK., Hill AVS; 1The Jenner Institute, University of Oxford, Oxford, OX3 7DQ UK.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2018 Oct 09; Vol. 3, pp. 49. Date of Electronic Publication: 2018 Oct 09 (Print Publication: 2018).

Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP.

Autor: Rampling T; The Jenner Institute., Ewer KJ; The Jenner Institute., Bowyer G; The Jenner Institute., Bliss CM; The Jenner Institute., Edwards NJ; The Jenner Institute., Wright D; The Jenner Institute., Payne RO; The Jenner Institute., Venkatraman N; The Jenner Institute., de Barra E; Royal College of Surgeons in Ireland, Dublin., Snudden CM; The Jenner Institute., Poulton ID; The Jenner Institute., de Graaf H; NIHR Wellcome Trust Clinical Research Facility, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom., Sukhtankar P; NIHR Wellcome Trust Clinical Research Facility, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom., Roberts R; The Jenner Institute., Ivinson K; PATH Malaria Vaccine Initiative, Seattle, Washington., Weltzin R; PATH Malaria Vaccine Initiative, Seattle, Washington., Rajkumar BY; PATH Malaria Vaccine Initiative, Seattle, Washington., Wille-Reece U; PATH Malaria Vaccine Initiative, Seattle, Washington., Lee CK; PATH Malaria Vaccine Initiative, Seattle, Washington., Ockenhouse CF; PATH Malaria Vaccine Initiative, Seattle, Washington., Sinden RE; Department of Life Sciences., Gerry S; Centre for Statistics in Medicine, University of Oxford., Lawrie AM; The Jenner Institute., Vekemans J; GSK Vaccines, Rixensart, Belgium., Morelle D; GSK Vaccines, Rixensart, Belgium., Lievens M; GSK Vaccines, Rixensart, Belgium., Ballou RW; GSK Vaccines, Rixensart, Belgium., Cooke GS; Infectious Diseases Section, Faculty of Medicine, Department of Medicine, Imperial College London., Faust SN; NIHR Wellcome Trust Clinical Research Facility, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom., Gilbert S; The Jenner Institute., Hill AV; The Jenner Institute.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2016 Sep 01; Vol. 214 (5), pp. 772-81. Date of Electronic Publication: 2016 Jun 15.

Rapid detection of Leishmania amastigotes in fluid aspirates and biopsies of human tissues.

Autor: Anthony RL; Department of Pathology, University of Maryland School of Medicine, Baltimore 21201., Grogl M, Sacci JB, Ballou RW

Publikováno v: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 1987 Sep; Vol. 37 (2), pp. 271-6.