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Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1

Autor: Wiegard, Anika, Kuzin, Vladislav, Cameron, Donald P., Grosser, Jan, Ceribelli, Michele, Mehmood, Rashid, Ballarino, Roberto, Valant, Francesco, Grochowski, Radosław, Karabogdan, Ivana, Crosetto, Nicola, Lindqvist, Arne, Bizard, Anna Helene, Kouzine, Fedor, Natsume, Toyoaki, Baranello, Laura

Publikováno v: In Molecular Cell 16 December 2021 81(24):5007-5024

An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination

Autor: Ballarino, Roberto, Bouwman, Britta A. M., Agostini, Federico, Harbers, Luuk, Diekmann, Constantin, Wernersson, Erik, Bienko, Magda, Crosetto, Nicola

Publikováno v: Scientific Data. 9

Endogenous DNA double-strand breaks (DSBs) occurring in neural cells have been implicated in the pathogenesis of neurodevelopmental disorders (NDDs). Currently, a genomic map of endogenous DSBs arising during human neurogenesis is missing. Here, we a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2424a3a39cf4da77dbdc76100f3d55b
https://doi.org/10.1038/s41597-022-01508-x

Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis.

Autor: Mastropasqua F; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Oksanen M; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Soldini C; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Alatar S; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Arora A; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Ballarino R; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17164 Stockholm, Sweden.; Science for Life Laboratory, Tomtebodavägen 23A, 17165 Solna, Sweden.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165 Stockholm, Sweden., Molinari M; Department of Neuroscience, Karolinska Institutet, 17176 Solna, Sweden., Agostini F; Science for Life Laboratory, Tomtebodavägen 23A, 17165 Solna, Sweden.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165 Stockholm, Sweden., Poulet A; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA., Watts M; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Rabkina I; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Becker M; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Li D; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden., Anderlid BM; Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden.; Department of Clinical Genetics, Karolinska University Hospital, 17164 Stockholm, Sweden., Isaksson J; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Department of Medical Sciences, Child and Adolescent Psychiatry Unit, Uppsala University, 75309 Uppsala, Sweden., Lundin Remnelius K; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden., Moslem M; Department of Neuroscience, Karolinska Institutet, 17176 Solna, Sweden., Jacob Y; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA., Falk A; Department of Neuroscience, Karolinska Institutet, 17176 Solna, Sweden.; Lund Stem Cell Center, Lund University, 22100 Lund, Sweden., Crosetto N; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17164 Stockholm, Sweden.; Science for Life Laboratory, Tomtebodavägen 23A, 17165 Solna, Sweden.; Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milan, Italy., Bienko M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17164 Stockholm, Sweden.; Science for Life Laboratory, Tomtebodavägen 23A, 17165 Solna, Sweden.; Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milan, Italy., Santini E; Department of Neuroscience, Karolinska Institutet, 17176 Solna, Sweden., Borgkvist A; Department of Neuroscience, Karolinska Institutet, 17176 Solna, Sweden., Bölte S; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden.; Curtin Autism Research Group , Curtin School of Allied Health, Curtin University, 6845 Perth, Western Australia.; Child and Adolescent Psychiatry , Stockholm Health Care Services, Region Stockholm, 10431 Stockholm, Sweden., Tammimies K; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institute, Region Stockholm, 17164 Stockholm, Sweden.; Astrid Lindgren Children's Hospital , Karolinska University Hospital, Region Stockholm, 17164 Stockholm, Sweden.

Publikováno v: Biology open [Biol Open] 2023 Oct 15; Vol. 12 (10). Date of Electronic Publication: 2023 Oct 10.