A role for APP in Wnt signalling links synapse loss with β-amyloid production:Aβ synaptotoxicity drives Aβ production

Autor: Elliott, Christina Louise, Rojo, Ana I, Ribe, Elena, Broadstock, Martin, Xia, Weiming, Mornin, Peter, Semenov, mMikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive Gerald, Simons, Paul, Killick, Richard

Publikováno v: Elliott, C L, Rojo, A I, Ribe, E, Broadstock, M, Xia, W, Mornin, P, Semenov, MM, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, C G, Simons, P & Killick, R 2018, ' A role for APP in Wnt signalling links synapse loss with β-amyloid production : Aβ synaptotoxicity drives Aβ production ', Translational psychiatry, vol. 8, no. 1, 179 . https://doi.org/10.1038/s41398-018-0231-6

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::e60324fbda4fd9452dab507f1fd82a0b
https://kclpure.kcl.ac.uk/ws/files/147552094/A_role_for_APP_in_Wnt_signalling_links_KILLICK_Publishedonline20September2018_GOLD_VoR_CC_BY_.pdf

Helping staff to implement psychosocial interventions in care homes: augmenting existing practices and meeting needs for support

Autor: Lawrence, Vanessa Claire, Fossey, Jane, Ballard, Clive Gerald, Ferreira, Nicola Cindy, Murray, Joanna

Publikováno v: Lawrence, V C, Fossey, J, Ballard, C G, Ferreira, N C & Murray, J 2016, ' Helping staff to implement psychosocial interventions in care homes: augmenting existing practices and meeting needs for support. ', International Journal of Geriatric Psychiatry, vol. 31, no. 3, pp. 284–293 . https://doi.org/10.1002/gps.4322

OBJECTIVE:To contribute to an optimised training programme for care staff that supports the implementation of evidence-based psychosocial interventions in long-term care.METHODS:Qualitative study that involved focus group discussions with 119 care ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::a7b7c14eb8c29cd1b8d3b720b88009b8
https://kclpure.kcl.ac.uk/ws/files/47275177/Implementing_psychosocial_interventions.docx