Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Balint Dudas"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2548-2564 (2024)
P-glycoprotein (P-gp) plays a crucial role in cellular detoxification and drug efflux processes, transitioning between inward-facing (IF) open, occluded, and outward-facing (OF) states to facilitate substrate transport. Its role is critical in cancer
Externí odkaz:
https://doaj.org/article/a89cc4aff34b495182c4b60c28beb7de
Autor:
Janka Czigleczki, Pedro Tulio de Resende Lara, Balint Dudas, Hyunbum Jang, David Perahia, Ruth Nussinov, Erika Balog
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The small GTPase Ran is the main regulator of the nucleo-cytoplasmic import and export through the nuclear pore complex. It functions as a molecular switch cycling between the GDP-bound inactive and GTP-bound active state. It consists of a globular (
Externí odkaz:
https://doaj.org/article/fb2f3ed2fd574327af55af3e43561ff4
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105290- (2022)
Summary: UDP-glucuronosyltransferases (UGTs) are responsible for 35% of the phase II drug metabolism. In this study, we focused on UGT1A1, which is a key UGT isoform. Strong inhibition of UGT1A1 may trigger adverse drug/herb-drug interactions, or res
Externí odkaz:
https://doaj.org/article/b3dedb5de0b24146a94f7f346687dc57
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift o
Externí odkaz:
https://doaj.org/article/ece2219aba824e04a7c747cf0ec901a5
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract RalF is an Arf GEF from Legionella pneumophilia, the bacterium that causes severe pneumonia. In its crystal structure, RalF is in the autoinhibited form. A large-scale domain motion is expected to lift the autoinhibition, the mechanism of wh
Externí odkaz:
https://doaj.org/article/959fe3fd1e35472f80ac15409616d5d0
Autor:
Burak T. Kaynak, James M. Krieger, Balint Dudas, Zakaria L. Dahmani, Mauricio G. S. Costa, Erika Balog, Ana Ligia Scott, Pemra Doruker, David Perahia, Ivet Bahar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Recent years have seen several hybrid simulation methods for exploring the conformational space of proteins and their complexes or assemblies. These methods often combine fast analytical approaches with computationally expensive full atomic molecular
Externí odkaz:
https://doaj.org/article/902b2f3af6304360bc36b423da15694c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
K-Ras is one of the most frequently mutated oncogenes in human tumor cells. It consists of a well-conserved globular catalytic domain and a flexible tail-like hypervariable region (HVR) at its C-terminal end. It plays a key role in signaling networks
Externí odkaz:
https://doaj.org/article/6078fe27c09944f5b5bc82527d343c75
Protein function is closely related to its structure and dynamics. Due to its large number of degrees of freedom, proteins adopt a large number of conformations, which describe a highly complex potential energy landscape. Considering the huge ensembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03884aa5c9f1c1ebc1ef74e0096e3d7
https://doi.org/10.1101/2022.11.29.517349
https://doi.org/10.1101/2022.11.29.517349
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
RalF is an Arf GEF from Legionella pneumophilia, the bacterium that causes severe pneumonia. In its crystal structure, RalF is in the autoinhibited form. A large-scale domain motion is expected to lift the autoinhibition, the mechanism of which is st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b6d422484030eb987bcfb56ba874d5
https://doi.org/10.1038/s41598-021-89169-5
https://doi.org/10.1038/s41598-021-89169-5
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae77d4624bb8eff13dbc10be1400c8f8
https://pubmed.ncbi.nlm.nih.gov/34162941
https://pubmed.ncbi.nlm.nih.gov/34162941