Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Baldwin Rf"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1985-1990
The preparation and activity of a series of hydroxyacetophenone/diaryl ether LTB 4 receptor antagonists are described. The key acid-substituted diaryl ether moiety is discussed in relation to the spatial and functional group requirements of the LTB 4
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1981-1984
The preparation and pharmacologic activity of two new hybrid LTB4 receptor antagonists, 1 and 2 (LY282210), are reported. These compounds are among the most potent in vitro LTB4 receptor antagonists yet described, and add new insight into the critica
Autor:
Jason Scott Sawyer, Floreancig Paul Edward, D. L. Jun. Saussy, Carlos R. Roman, Peter W. Stengel, Larry L. Froelich, Jerome H. Fleisch, Michael J. Sofia, Bach Nicholas J, Stephen Richard Baker, Sandra L. Cockerham, Stephen M. Spaethe, P. Marder, Elisabeth A. Schmittling, Baldwin Rf, J. A. Palkowitz, P. S. Borromeo, William T. Jackson, Steven A. Silbaugh
Publikováno v:
ChemInform. 27
Autor:
David K. Herron, Bollinger Ng, Baldwin Rf, Jason Scott Sawyer, Carlos R. Roman, Richard Waltz Harper, L E Rinkema, Jerome H. Fleisch
Publikováno v:
Journal of Medicinal Chemistry. 35:1191-1200
A hypothetical model for receptor binding of leukotriene D4 (LTD4) was deduced from conformational analysis of LTD4 and from the structure-activity relationships (SAR) of known LTD4 receptor antagonists. A new structural series of LTD4 receptor antag
Autor:
C. R. Roman, Michael J. Sofia, Baldwin Rf, Sandra L. Cockerham, S. A. Silbaugh, K. Nelson, Larry L. Froelich, P. Marder, Floreancig Paul Edward, Stephen Richard Baker, P. W. Stengel, Jason Scott Sawyer, S. M. Spaethe, D. L. Saussy, J. H. Fleisch, W. T. Jackson, Bach Nicholas J
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374305
Leukotriene B4 (LTB4) has been implicated as a key pro-inflammatory mediator in human diseases such as asthma, inflammatory bowel disease, psoriasis and arthritis (1). LTB4’s role in human disease is supported by the fact that via G-protein coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ac724edeb191b804e43ef5b753a2f4
https://doi.org/10.1007/978-1-4615-5325-0_51
https://doi.org/10.1007/978-1-4615-5325-0_51
Autor:
Sandra L. Cockerham, Larry L. Froelich, Baker, Baldwin Rf, Jason Scott Sawyer, Bach Nicholas J, Jerome H. Fleisch, William T. Jackson, P. S. Borromeo, Floreancig Paul Edward
Publikováno v:
Journal of medicinal chemistry. 38(22)
Structural derivatives of LY255283 have been studied as receptor antagonists of leukotriene B 4 . Substitution of the 2-hydroxyacetophenone subunit of 1 (LY255283) with a 2-arylphenol group provided entry into several new series that feature various
Autor:
Baldwin Rf, P. W. Stengel, Sandra L. Cockerham, D. L. Saussy, Larry L. Froelich, Michael J. Sofia, Floreancig Paul Edward, P. Marder, S. A. Silbaugh, Jason Scott Sawyer
Publikováno v:
Journal of medicinal chemistry. 36(24)
Publikováno v:
Journal of medicinal chemistry. 35(7)
This report describes the development of a series of highly potent quinoline-based leukotriene D4 (LTD4) receptor antagonists containing an N-benzyl-substituted phenyltetrazole moiety. They were designed to provide both the correct positioning of the
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.