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Deacetoxycephalosporin C synthase is an iron(II) 2-oxoglutaratedependent oxygenase that catalyzes the oxidative ring-expansion of penicillin N to deacetoxycephalosporin C. The wild-type enzyme is only able to efficiently utilize 2-oxoglutarate and 2-
Externí odkaz:
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https://ora.ox.ac.uk/objects/uuid:f8904bd0-8b4b-46c2-b65a-75e8eecaa764
https://ora.ox.ac.uk/objects/uuid:f8904bd0-8b4b-46c2-b65a-75e8eecaa764
Autor:
Roach, PL, Clifton, IJ, Hensgens, CMH, Shibata, N, Long, AJ, Strange, RW, Hasnain, SS, Schofield, CJ, Baldwin, JE, Hajdu, J
Externí odkaz:
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https://ora.ox.ac.uk/objects/uuid:38c8e8ba-a27e-41ec-9f1e-2c3abb146e30
The substrate analog L-S-(a-aminoadipoyl)-L-cysteinyl-glycine (ACG) was co-crystallised with isopenicillin N synthase using the hanging-drop vapourdiffusion method in an anaerobic environment. ' X-ray crystallography revealed a different mode of bind
Externí odkaz:
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https://ora.ox.ac.uk/objects/uuid:615d0e21-d29d-4a61-906b-2dd2b826611a
https://ora.ox.ac.uk/objects/uuid:615d0e21-d29d-4a61-906b-2dd2b826611a
Autor:
Yao, Zhouchi1 (AUTHOR), Zeng, Yayun2 (AUTHOR), Liu, Cheng1 (AUTHOR), Jin, Huimin2 (AUTHOR), Wang, Hong3 (AUTHOR), Zhang, Yue2 (AUTHOR) 2021000048@usc.edu.cn, Ding, Chengming1 (AUTHOR) 2018011096@usc.edu.cn, Chen, Guodong1 (AUTHOR) chenguodong@usc.edu.cn, Wu, Daichao1,2 (AUTHOR) wudaichao@usc.edu.cn
Publikováno v:
Journal of Experimental & Clinical Cancer Research (17569966). 9/28/2024, Vol. 43 Issue 1, p1-30. 30p.
Autor:
Hewitson Ks, Baldwin Je, Peter L. Roach, Yiannis Sanakis, Ollagnier-De Choudens S, Marc Fontecave, Eckard Münck
Publikováno v:
Biochemistry. 39:4165-4173
Biotin synthase and lipoate synthase are homodimers that are required for the C-S bond formation at nonactivated carbon in the biosynthesis of biotin and lipoic acid, respectively. Aerobically isolated monomers were previously shown to contain a (2Fe
Autor:
Kuan KKW; Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia., Markwell-Heys AW; Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia., Cruickshank MC; Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia., Tran DP; Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia., Adlington RM; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Baldwin JE; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., George JH; Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: jonathan.george@adelaide.edu.au.
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Jun 15; Vol. 27 (12), pp. 2449-2465. Date of Electronic Publication: 2019 Feb 19.
Autor:
Lockwood, Thomas E.1 (AUTHOR), Angeloski, Alexander2 (AUTHOR) angelosa@ansto.gov.au
Publikováno v:
Journal of Cheminformatics. 3/28/2024, Vol. 16 Issue 1, p1-7. 7p.