Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Baldwin C. Mak"'
Autor:
Baldwin C. Mak, Bryan T. Addeman, Jia Chen, Kim A. Papp, Melinda J. Gooderham, Lyn C. Guenther, Yi Liu, Uli C. Broedl, Marianne E. Logger
Publikováno v:
Blockchain in Healthcare Today (2021)
Objective: Despite the implementation of quality assurance procedures, current clinical trial management processes are time-consuming, costly, and often susceptible to error. This can result in limited trust, transparency, and process inefficiencies,
Externí odkaz:
https://doaj.org/article/c0ecc47c1cbb4e788492b5fa089a7ded
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 43:617-627
Mutations in the tumor suppressor tuberin (TSC2) are a common factor in the development of lymphangioleiomyomatosis (LAM). LAM is a cystic lung disease that is characterized by the infiltration of smooth muscle-like cells into the pulmonary parenchym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0f75d5b2f8d4758a1227b0b7bf2aa3
https://doi.org/10.1165/rcmb.2008-0335oc
https://doi.org/10.1165/rcmb.2008-0335oc
Autor:
Heather P. Harding, Wilson Lee, David Ron, Donalyn Scheuner, Christopher A. McCulloch, Carol Laschinger, Qin Wang, Baldwin C. Mak, Randal J. Kaufman, Richard C. Austin
Publikováno v:
Journal of Biological Chemistry. 283:23462-23472
Induction of apoptosis by tensile forces is an important determinant of connective tissue destruction in osteoarthritis and periodontal diseases. We examined the role of molecular components of the unfolded protein response in force-induced apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c34e22aa76450c720e7748abf2a9f64
https://doi.org/10.1074/jbc.m803194200
https://doi.org/10.1074/jbc.m803194200
Autor:
Raymond S. Yeung, Baldwin C. Mak
Publikováno v:
Cancer Investigation. 22:588-603
The study of hereditary tumor syndromes has laid a solid foundation toward understanding the genetic basis of cancer. One of the latest examples comes from the study of tuberous sclerosis complex (TSC). As a member of the phakomatoses, TSC is charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8c091adf64d2981a6428af9573e422
https://doi.org/10.1081/cnv-200027144
https://doi.org/10.1081/cnv-200027144
Publikováno v:
Journal of Biological Chemistry. 278:5947-5951
Tuberous sclerosis complex (TSC) is characterized by the formation of hamartomas in multiple organs resulting from mutations in the TSC1 or TSC2 gene. Their protein products, hamartin and tuberin, respectively, form a functional complex that affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f8c5f3e862c79c843506b1ca190ca8
https://doi.org/10.1074/jbc.c200473200
https://doi.org/10.1074/jbc.c200473200
Publikováno v:
Journal of Biological Chemistry. 277:13589-13596
The matrix metalloproteinases (MMPs) are a family of endoproteinases that degrade various components of the extracellular matrix and have been implicated in the pathogenesis of multiple sclerosis. To determine whether up-regulation of MMP-3, or strom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff94e93d54e3f450832556910105158
https://doi.org/10.1074/jbc.m108817200
https://doi.org/10.1074/jbc.m108817200
Publikováno v:
Journal of Neuroscience Research. 53:143-152
Transgenic mice (ND4) containing 70 copies of the transgene encoding DM20 were clinically normal up to 3 months of age, spontaneously demyelinated there-after and died in 8-10 months. Whereas the myelin fraction from normal mice increased in amount f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b216a5f709a155c5c83ca1963f0e3a
https://doi.org/10.1002/(sici)1097-4547(19980715)53:2<143::aid-jnr3>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19980715)53:2<143::aid-jnr3>3.0.co
Publikováno v:
Archives of biochemistry and biophysics. 404(2)
Mutations of the TSC1 and TSC2 genes give rise to the clinical disorder of tuberous sclerosis characterized by the development of hamartomas predominantly affecting the central nervous system, kidney, skin, lung, and heart. The function of the gene p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f21b29230d3346f0fd1029b9fda143b
https://pubmed.ncbi.nlm.nih.gov/12147258
https://pubmed.ncbi.nlm.nih.gov/12147258