Hidden Semi-Markov Models for Single-Molecule Conformational Dynamics

Autor: Kovalev, A., Zarrabi, N., Werz, F., Boersch, M., Ristic, Z., Lill, H., Bald, D., Tietz, C., Wrachtrup, J.

The conformational kinetics of enzymes can be reliably revealed when they are governed by Markovian dynamics. Hidden Markov Models (HMMs) are appropriate especially in the case of conformational states that are hardly distinguishable. However, the ev

Externí odkaz: http://arxiv.org/abs/0902.0622

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ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction

Autor: Haagsma, A.C., Driessen, N.N., Hahn, M.M., Lill, H., Bald, D.

Publikováno v: FEMS Microbiology Letters, 313, 68-74
FEMS Microbiology Letters, 313, 1, pp. 68-74

Item does not contain fulltext ATP synthase is a validated drug target for the treatment of tuberculosis, and ATP synthase inhibitors are promising candidate drugs for the treatment of infections caused by other slow-growing mycobacteria, such as Myc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::374bedcb91161ee727a428b627e1c9ea
https://hdl.handle.net/2066/87236

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Novel antibiotics targeting respiratory ATP in Gram-positive pathogenic bacteria

Autor: Balemans, W., Vranckx, L., Lounis, N., Pop, O., Guillemont, J., Vergauwen, K, Mol, S., Gilissen, R., Motte, M., Lanois, D., de Bolle, M., Bonroy, K., Lill, H., Andries, K., Bald, D., Koul, A.

Publikováno v: Antimicrobial Agents and Chemotherapy, 56, 4131-4139. American Society for Microbiology
Balemans, W, Vranckx, L, Lounis, N, Pop, O, Guillemont, J, Vergauwen, K, Mol, S, Gilissen, R, Motte, M, Lanois, D, de Bolle, M, Bonroy, K, Lill, H, Andries, K, Bald, D & Koul, A 2013, ' Novel antibiotics targeting respiratory ATP in Gram-positive pathogenic bacteria ', Antimicrobial Agents and Chemotherapy, vol. 56, pp. 4131-4139 . https://doi.org/10.1128/AAC.00273-12

Emergence of drug-resistant bacteria represents a high, unmet medical need, and discovery of new antibacterials acting on new bacterial targets is strongly needed. ATP synthase has been validated as an antibacterial target in Mycobacterium tuberculos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::08733afb06b07d2fc2a307204ec4a161
https://research.vu.nl/en/publications/692acbc0-f87c-429b-acef-3a35a661f70c