Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Balca R Mardin"'
Autor:
Özdemirhan Serçin, Sabine Reither, Paris Roidos, Nadja Ballin, Spyridon Palikyras, Anna Baginska, Katrin Rein, Maria Llamazares, Aliaksandr Halavatyi, Hauke Winter, Thomas Muley, Renata Z Jurkowska, Amir Abdollahi, Frank T Zenke, Beate Neumann, Balca R Mardin
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp 1-13 (2019)
Abstract Arrayed CRISPR‐based screens emerge as a powerful alternative to pooled screens making it possible to investigate a wide range of cellular phenotypes that are typically not amenable to pooled screens. Here, we describe a solid‐phase tran
Externí odkaz:
https://doaj.org/article/6ccf8258efa147ae81dc59c197e3f2c6
Autor:
Özdemirhan Serçin, Sabine Reither, Paris Roidos, Nadja Ballin, Spyridon Palikyras, Anna Baginska, Katrin Rein, Maria Llamazares, Aliaksandr Halavatyi, Hauke Winter, Thomas Muley, Renata Z Jurkowska, Amir Abdollahi, Frank T Zenke, Beate Neumann, Balca R Mardin
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/794bf89ed59d4f77b1ffbbe5e6ffea7e
Autor:
Balca R Mardin, Alexandros P Drainas, Sebastian M Waszak, Joachim Weischenfeldt, Mayumi Isokane, Adrian M Stütz, Benjamin Raeder, Theocharis Efthymiopoulos, Christopher Buccitelli, Maia Segura‐Wang, Paul Northcott, Stefan M Pfister, Peter Lichter, Jan Ellenberg, Jan O Korbel
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 9, Pp 1-13 (2015)
Abstract A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one‐off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). Largely due to lack of suitabl
Externí odkaz:
https://doaj.org/article/4ae82bd2680e4838bba1e601082ba12c
Autor:
Alexandros P. Drainas, Ruxandra A. Lambuta, Irina Ivanova, Özdemirhan Serçin, Ioannis Sarropoulos, Mike L. Smith, Theocharis Efthymiopoulos, Benjamin Raeder, Adrian M. Stütz, Sebastian M. Waszak, Balca R. Mardin, Jan O. Korbel
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: TP53 deficiency is the most common alteration in cancer; however, this alone is typically insufficient to drive tumorigenesis. To identify genes promoting tumorigenesis in combination with TP53 deficiency, we perform genome-wide CRISPR-Cas9
Externí odkaz:
https://doaj.org/article/b32ada33421547e3bbddbb495b192552
Autor:
Uwe Schwartz, Maria Llamazares Prada, Stephanie T Pohl, Mandy Richter, Raluca Tamas, Michael Schuler, Corinna Keller, Vedrana Mijosek, Thomas Muley, Marc A Schneider, Karsten Quast, Joschka Hey, Claus P Heußel, Arne Warth, Hauke Winter, Özdemirhan Serçin, Harry Karmouty‐Quintana, Soma SK Jyothula, Manish K Patel, Felix Herth, Ina Koch, Giuseppe Petrosino, Alexandru Titimeaua, Balca R Mardin, Dieter Weichenhan, Tomasz P Jurkowski, Charles D Imbusch, Benedikt Brors, Vladimir Benes, Birgit Jung, David Wyatt, Heiko F Stahl, Christoph Plass, Renata Z Jurkowska
Publikováno v:
The EMBO Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add00c93d6e45af914fbf764adb11af1
https://doi.org/10.15252/embj.2022111272
https://doi.org/10.15252/embj.2022111272
Autor:
Konstantina Rowald, Martina Mantovan, Joana Passos, Christopher Buccitelli, Balca R. Mardin, Jan O. Korbel, Martin Jechlinger, Rocio Sotillo
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2679-2691 (2016)
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mitotic chec
Externí odkaz:
https://doaj.org/article/b18daaf5285944e4bbc910a431353d51
Autor:
Nikos Sidiropoulos, Balca R. Mardin, F. Germán Rodríguez-González, Ivan D. Bochkov, Shilpa Garg, Adrian M. Stütz, Jan O. Korbel, Erez Lieberman Aiden, Joachim Weischenfeldt
Publikováno v:
Sidiropoulos, N, Mardin, B R, Rodríguez-González, F G, Bochkov, I D, Garg, S, Stuetz, A M, Korbel, J O, Aiden, E L & Weischenfeldt, J 2022, ' Somatic structural variant formation is guided by and influences genome architecture ', Genome Research, vol. 32, no. 4, pp. 643-655 . https://doi.org/10.1101/gr.275790.121
The occurrence and formation of genomic structural variants (SVs) is known to be influenced by the 3D chromatin architecture, but the extent and magnitude have been challenging to study. Here, we apply Hi-C to study chromatin organization before and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8056fc288d66c415bf66b3255171aa0
https://doi.org/10.1101/gr.275790.121
https://doi.org/10.1101/gr.275790.121
Autor:
Uwe Schwartz, Maria Llamazares Prada, Stephanie T. Pohl, Mandy Richter, Raluca Tamas, Michael Schuler, Corinna Keller, Vedrana Mijosek, Thomas Muley, Marc A. Schneider, Karsten Quast, Joschka Hey, Claus P. Heußel, Arne Warth, Hauke Winter, Özdemirhan Serçin, Harry Karmouty-Quintana, Felix Herth, Ina Koch, Giuseppe Petrosino, Balca R. Mardin, Dieter Weichenhan, Tomasz P. Jurkowski, Charles D. Imbusch, Benedikt Brors, Vladimir Benes, Brigit Jung, David Wyatt, Heiko Stahl, Christoph Plass, Renata Z. Jurkowska
Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering the environmental cause of COPD (e.g., cigarette smoke) and disease phenotypes, including stem-cell senescence and impaired differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85bd90abe91fb9904d07649ca3115e87
https://doi.org/10.1101/2022.03.28.486023
https://doi.org/10.1101/2022.03.28.486023
Autor:
Paris Roidos, Stephanie Sungalee, Amir Abdollahi, Özdemirhan Serçin, Jan O. Korbel, Adrian M. Stütz, Jan Mauer, Salvatore Benfatto, Frank Zenke, Balca R. Mardin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Double-strand breaks (DSBs) are the most toxic type of DNA lesions. Cells repair these lesions using either end protection- or end resection-coupled mechanisms. To study DSB repair choice, we present the Color Assay Tracing-Repair (CAT-R) to simultan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a496afd174991f7e538e855142eb11
http://link.springer.com/article/10.1038/s41467-020-17962-3
http://link.springer.com/article/10.1038/s41467-020-17962-3
Autor:
Zuzana Storchova, Vincent Leon Gotsmann, Narendra Kumar Chunduri, Christopher Buccitelli, Balca R. Mardin, Raeschle M, Angela Wieland, Xiaoxiao Zhang, Maik Kschischo, Paul Menges, Jan O. Korbel, Felix Willmund
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find that chromosome loss impairs proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bac84858436c5614fd22dfff68de3e
https://doi.org/10.1038/s41467-021-25288-x
https://doi.org/10.1038/s41467-021-25288-x