Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Balazs Szoor"'
Autor:
Eleanor Silvester, Balazs Szoor, Alasdair Ivens, Georgina Awuah-Mensah, Catarina Gadelha, Bill Wickstead, Keith R Matthews
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011889 (2024)
Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG
Externí odkaz:
https://doaj.org/article/d12859edc02f4c27a5132d16e0815e5b
SummaryThe development ofTrypanosoma bruceiin its mammalian host is marked by a distinct morphological change as replicative “slender” forms differentiate into cell-cycle arrested “stumpy” forms in a quorum-sensing dependent manner. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a95a9fbce40c71845fc87068dd6ecb4
https://doi.org/10.1101/2023.04.06.535835
https://doi.org/10.1101/2023.04.06.535835
Autor:
Albert Gerding, Freek J. H. Sorgdrager, Francois du Toit, Hermann-Georg Holzhütter, Klaas Nico Faber, Jacky L. Snoep, Keith R. Matthews, Amalia M. Dolga, Hans V. Westerhoff, Barbara M. Bakker, Jurgen R. Haanstra, Balazs Szoor, Manon Buist-Homan
Publikováno v:
Scientific Reports, 7:40406. Nature Publishing Group
Scientific Reports
Haanstra, J R, Gerding, A, Dolga, A M, Sorgdrager, F J H, Buist-Homan, M, du Toit, F, Faber, K N, Holzhütter, H-G, Szöör, B, Matthews, K R, Snoep, J, Westerhoff, H V & Bakker, B M 2017, ' Targeting pathogen metabolism without collateral damage to the host ', Scientific Reports, vol. 7, pp. 40406 . https://doi.org/10.1038/srep40406
Haanstra, J R, Gerding, A, Dolga, A M, Sorgdrager, F J H, Buist-Homan, M, du Toit, F, Faber, K N, Holzhutter, H-G, Szoor, B, Matthews, K, Snoep, J L, Westerhoff, H V & Bakker, B M 2017, ' Targeting pathogen metabolism without collateral damage to the host ', Scientific Reports, vol. 7, 40406 . https://doi.org/10.1038/srep40406
Haanstra, J R, Gerding, A, Dolga, A M, Sorgdrager, F J, Buist-Homan, M, du Toit, F, Faber, K N, Holzhutter, H G, Szoor, B, Matthews, K R, Snoep, J L, Westerhoff, H V & Bakker, B M 2017, ' Targeting pathogen metabolism without collateral damage to the host. ', Scientific Reports, vol. 7, 40406 . https://doi.org/10.1038/srep40406
Scientific Reports
Haanstra, J R, Gerding, A, Dolga, A M, Sorgdrager, F J H, Buist-Homan, M, du Toit, F, Faber, K N, Holzhütter, H-G, Szöör, B, Matthews, K R, Snoep, J, Westerhoff, H V & Bakker, B M 2017, ' Targeting pathogen metabolism without collateral damage to the host ', Scientific Reports, vol. 7, pp. 40406 . https://doi.org/10.1038/srep40406
Haanstra, J R, Gerding, A, Dolga, A M, Sorgdrager, F J H, Buist-Homan, M, du Toit, F, Faber, K N, Holzhutter, H-G, Szoor, B, Matthews, K, Snoep, J L, Westerhoff, H V & Bakker, B M 2017, ' Targeting pathogen metabolism without collateral damage to the host ', Scientific Reports, vol. 7, 40406 . https://doi.org/10.1038/srep40406
Haanstra, J R, Gerding, A, Dolga, A M, Sorgdrager, F J, Buist-Homan, M, du Toit, F, Faber, K N, Holzhutter, H G, Szoor, B, Matthews, K R, Snoep, J L, Westerhoff, H V & Bakker, B M 2017, ' Targeting pathogen metabolism without collateral damage to the host. ', Scientific Reports, vol. 7, 40406 . https://doi.org/10.1038/srep40406
The development of drugs that can inactivate disease-causing cells (e.g. cancer cells or parasites) without causing collateral damage to healthy or to host cells is complicated by the fact that many proteins are very similar between organisms. Nevert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2067079265acdaed4ee04a04133c77a5
https://research.rug.nl/en/publications/54931dcc-7b52-480c-b782-f70e67fa955b
https://research.rug.nl/en/publications/54931dcc-7b52-480c-b782-f70e67fa955b
Publikováno v:
Chemical Biology & Drug Design. 81:291-301
Protein tyrosine phosphatase 1B (PTP1B) is one of the most attractive phosphatase targets in the field of drug discovery. PTP1B is a negative regulator of the insulin and leptin pathways, and mice deficient for this gene show increased sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32394a951e8612f853668bdb75482c8b
https://doi.org/10.1111/cbdd.12079
https://doi.org/10.1111/cbdd.12079
Autor:
Balazs Szoor
Publikováno v:
Szoor, B 2010, ' Trypanosomatid protein phosphatases ', Molecular and Biochemical Parasitology, vol. 173, no. 2, pp. 53-63 . https://doi.org/10.1016/j.molbiopara.2010.05.017
Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology
Graphical abstract Classification of kinetoplastid serine/threonine specific and protein tyrosine phosphatases based on sequence similarity. The groups absent from kinetoplastids are in white boxes. In spite of well-described kinetoplastid phosphatom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db37fbc807a4895af832f749ce968f61
https://doi.org/10.1016/j.molbiopara.2010.05.017
https://doi.org/10.1016/j.molbiopara.2010.05.017
Publikováno v:
Szoor, B, Haanstra, J R, Gualdrón-López, M & Michels, P A M 2014, ' Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids ', Current Opinion in Microbiology, vol. 22, pp. 79-87 . https://doi.org/10.1016/j.mib.2014.09.006
Szoor, B, Haanstra, J R, Gualdron-Lopez, M & Michels, P A M 2014, ' Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids. ', Current Opinion in Microbiology, vol. 22, pp. 79-87 . https://doi.org/10.1016/j.mib.2014.09.006
Current Opinion in Microbiology, 22, 79-87. Elsevier Limited
Szoor, B, Haanstra, J R, Gualdron-Lopez, M & Michels, P A M 2014, ' Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids. ', Current Opinion in Microbiology, vol. 22, pp. 79-87 . https://doi.org/10.1016/j.mib.2014.09.006
Current Opinion in Microbiology, 22, 79-87. Elsevier Limited
Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes that uniquely contain enzymes of the glycolytic pathway and other parts of intermediary metabolism and hence are called glycosomes. Their specific enzyme content can vary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062e18d3b2b333d5e9fc81a3530bf05c
https://hdl.handle.net/20.500.11820/ef1d2e7f-8407-4ef5-a7cb-0f2b8be71baf
https://hdl.handle.net/20.500.11820/ef1d2e7f-8407-4ef5-a7cb-0f2b8be71baf
Publikováno v:
Archives of Biochemistry and Biophysics. 396:213-218
The methylotrophic yeast Pichia pastoris was used to express Drosophila melanogaster type 1β serine/threonine phosphoprotein phosphatase catalytic subunit (PP1β9C). A construct encoding PP1β9C with a short NH 2 -terminal fusion including six histi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237fe2236d3e706f20670a526ed4dd7
https://doi.org/10.1006/abbi.2001.2602
https://doi.org/10.1006/abbi.2001.2602
Autor:
Oded Yarden, Einat Yatzkan, Zsigmond Fehér, Tamás Zeke, Balazs Szoor, Viktor Dombrádi, Pál Gergely
Publikováno v:
Europe PubMed Central
The gene and cDNA of a novel protein phosphatase were cloned from Neurospora crassa. The pzl-1 gene encompasses three introns and is localized to the left arm of chromosome I between cyt-21 and Fsr-12. It encodes a protein of 58.3 kDa containing a Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c88ef50e94c95ec4ce17fec96feaff2
https://doi.org/10.1016/s0167-4838(98)00201-5
https://doi.org/10.1016/s0167-4838(98)00201-5
Autor:
Keith R. Matthews, Balazs Szoor
Publikováno v:
Protein Phosphorylation in Parasites Novel Targets for Antiparasitic Intervention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b46e4a3840cd8a96929892835e4687
https://doi.org/10.1002/9783527675401.ch08
https://doi.org/10.1002/9783527675401.ch08
Autor:
Pál Gergely, Viktor Dombrádi, Balazs Szoor, Ferenc Erdodi, Zsigmond Fehér, Gábor Szabó, Éva Bakó
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 112:515-522
The catalytic subunit of protein phosphatase 2A (PP2A c ) was purified from Neurospora crassa extract by (NH 4 ) 2 SO 4 -ethanol precipitation followed by DEAE-Sephacel, heparin-Sepharose, and MonoQ chromatography steps about 900-fold to a specific a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f1254033ddddeb6e98d8f8172422e2
https://doi.org/10.1016/0305-0491(95)00110-7
https://doi.org/10.1016/0305-0491(95)00110-7