Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Balazs Györffy"'
Autor:
Mihada Bajrami Saipi, Alessia Ruiba, Marcus Matthias Schittenhelm, Gunnar Blumenstock, Balázs Győrffy, Serena Fazio, Marlon Hafner, Anna-Lena Ahrens, Lara Aldinger, Vanessa Aellig, François G. Kavelaars, César Nombela-Arrieta, Falko Fend, Peter J. M. Valk, Driessen Christoph, Kerstin Maria Kampa-Schittenhelm
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-13 (2024)
Abstract Apoptosis-stimulating proteins of p53 (ASPPs) are a family of proteins that modulate key tumor suppressor pathways via direct interaction with p53. Deregulation of these proteins promotes cancer development and impairs sensitivity to systemi
Externí odkaz:
https://doaj.org/article/793637dff01642d6878a7b3b72ca88da
Autor:
Ella Waters, Perla Pucci, Ruman Rahman, Anna P Yatsyshyna, Harry Porter, Mark Hirst, Radka Gromnicova, Igor Kraev, Vera Mongiardini, Benedetto Grimaldi, Jon Golding, Helen L Fillmore, Balázs Győrffy, Priyadarsini Gangadharannambiar, Christos N Velanis, Christopher J Heath, Francesco Crea
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0312237 (2024)
The long non-coding RNA (lncRNA), HAR1A is emerging as a putative tumour suppressor. In non-neoplastic brain cells, REST suppresses HAR1A expression. In gliomas REST acts as an oncogene and is a potential therapeutic target. It is therefore conceivab
Externí odkaz:
https://doaj.org/article/c9807a1bb67247c59c737f1393640411
Autor:
Igor López-Cade, Vanesa García-Barberán, Esther Cabañas Morafraile, Cristina Díaz-Tejeiro, Cristina Saiz-Ladera, Adrián Sanvicente, Pedro Pérez Segura, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Identification of genomic alterations that influence the immune response within the tumor microenvironment is mandatory in order to identify druggable vulnerabilities. In this article, by interrogating public genomic datasets we describe copy number
Externí odkaz:
https://doaj.org/article/1300f7e3084a44b790a2bfcef5cea1aa
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/516e39ec17d14057a6dc69b801c36247
Autor:
Sumit Siddharth, Sheetal Parida, Nethaji Muniraj, Shawn Hercules, David Lim, Arumugam Nagalingam, Chenguang Wang, Balazs Gyorffy, Juliet M Daniel, Dipali Sharma
Publikováno v:
eLife, Vol 10 (2021)
Mortality from triple negative breast cancer (TNBC) is significantly higher in African American (AA) women compared to White American (WA) women emphasizing ethnicity as a major risk factor; however, the molecular determinants that drive aggressive p
Externí odkaz:
https://doaj.org/article/49eb6eb47dc644848fa946c47740a18e
Autor:
Hajnalka L Pálinkás, Angéla Békési, Gergely Róna, Lőrinc Pongor, Gábor Papp, Gergely Tihanyi, Eszter Holub, Ádám Póti, Carolina Gemma, Simak Ali, Michael J Morten, Eli Rothenberg, Michele Pagano, Dávid Szűts, Balázs Győrffy, Beáta G Vértessy
Publikováno v:
eLife, Vol 9 (2020)
Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we
Externí odkaz:
https://doaj.org/article/cf7a1b9f9d9c42cda6d001319a1a4ee2
Autor:
Sander AL Palit, Daniel Vis, Suzan Stelloo, Cor Lieftink, Stefan Prekovic, Elise Bekers, Ingrid Hofland, Tonći Šuštić, Liesanne Wolters, Roderick Beijersbergen, Andries M Bergman, Balázs Győrffy, Lodewyk FA Wessels, Wilbert Zwart, Michiel S van der Heijden
Publikováno v:
eLife, Vol 8 (2019)
Androgen receptor (AR) inhibitors represent the mainstay of prostate cancer treatment. In a genome-wide CRISPR-Cas9 screen using LNCaP prostate cancer cells, loss of co-repressor TLE3 conferred resistance to AR antagonists apalutamide and enzalutamid
Externí odkaz:
https://doaj.org/article/caac5d360d0a4963af4d216fca34abf4
Autor:
Carlos J Diaz Osterman, Duygu Ozmadenci, Elizabeth G Kleinschmidt, Kristin N Taylor, Allison M Barrie, Shulin Jiang, Lisa M Bean, Florian J Sulzmaier, Christine Jean, Isabelle Tancioni, Kristen Anderson, Sean Uryu, Edward A Cordasco, Jian Li, Xiao Lei Chen, Guo Fu, Marjaana Ojalill, Pekka Rappu, Jyrki Heino, Adam M Mark, Guorong Xu, Kathleen M Fisch, Vihren N Kolev, David T Weaver, Jonathan A Pachter, Balázs Győrffy, Michael T McHale, Denise C Connolly, Alfredo Molinolo, Dwayne G Stupack, David D Schlaepfer
Publikováno v:
eLife, Vol 8 (2019)
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities,
Externí odkaz:
https://doaj.org/article/7193db572cdc40948c8a07915a6afd96
Autor:
Lei Zhu, Barbara Hissa, Balázs Győrffy, Johann-Christoph Jann, Cui Yang, Christoph Reissfelder, Sebastian Schölch
Publikováno v:
Diagnostics, Vol 10, Iss 5, p 305 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most frequent cause of death from cancer. Circulating tumor cells (CTCs) with stem-like characteristics lead to distant metastases and thus contribute to the dismal prognosis of PDAC. Our purpose
Externí odkaz:
https://doaj.org/article/5dd1bec6cb9c4fdc856d07e05d9b62c7
Publikováno v:
Royal Society Open Science, Vol 5, Iss 12 (2018)
Background: Potential prognostic biomarker candidates for hepatocellular carcinoma (HCC) are abundant, but their generalizability is unexplored. We cross-validated markers of overall survival (OS) and vascular invasion in independent datasets. Method
Externí odkaz:
https://doaj.org/article/4dbe3480ec064d4eb5e832d016ef15a7