Utility of formalin-fixed, paraffin-embedded prostate biospecimens from low-resource settings for use in next-generation sequencing studies in African-descent populations

Autor: Ernest Kaninjing, Kayode A Adeniji, Andrew K Gachii, Paul Jibrin, John O Obafunwa, Chidiebere N Ogo, Mohammed Faruk, Ademola A Popoola, Omolara A Fatiregun, Olabode P Oluwole, William Aiken, Maria D Jackson, Robin A Roberts, Shravana Kumar Jyoti, Cherif Dial, Mohamed Jalloh, Lamine Niang, Medina Ndoye, Jason White, Balasubramanyam Karanam, Damian Francis, Denise Y Gibbs, Kathryn R Brignole, Clayton Yates, Camille Ragin, Folakemi T Odedina, Damali N Martin

Publikováno v: Journal of Global Health Reports, Vol 7 (2023)

# Background Men of African ancestry experience higher burden from prostate cancer compared to men of other ancestral backgrounds. Limitations in the availability of high-quality biospecimens hinder the inclusion of this population in genetic studie

Externí odkaz: https://doaj.org/article/a2bbb8aed5714afcb846664d7b345144

Molecular and pathological subtypes related to prostate cancer disparities and disease outcomes in African American and European American patients

Autor: Joakin O. Mori, Jason White, Isra Elhussin, Babatunde M. Duduyemi, Balasubramanyam Karanam, Clayton Yates, Honghe Wang

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Prostate cancer (PCa) disproportionately affects African American (AA) men, yet present biomarkers do not address the observed racial disparity. The objective of this study was to identify biomarkers with potential benefits to AA PCa patients. Differ

Externí odkaz: https://doaj.org/article/f0beb5931f6c47ad8f167f099719ded2

African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Autor: Manjunath Siddappa, Shahid Hussain, Sajad A. Wani, Jason White, Hancong Tang, Jaimie S. Gray, Hedieh Jafari, Hsu-Chang Wu, Mark D. Long, Isra Elhussin, Balasubramanyam Karanam, Honghe Wang, Rebecca Morgan, Gary Hardiman, Isaacson B. Adelani, Solomon O. Rotimi, Adam R. Murphy, Larisa Nonn, Melissa B. Davis, Rick A. Kittles, Chanita Hughes Halbert, Lara E. Sucheston-Campbell, Clayton Yates, Moray J. Campbell

Publikováno v: Siddappa, M, Hussain, S, Wani, S A, White, J, Tang, H, Gray, J S, Jafari, H, Wu, H-C, Long, M D, Elhussin, I, Karanam, B, Wang, H, Morgan, R, Hardiman, G, Adelani, I B, Rotimi, S O, Murphy, A R, Nonn, L, Davis, M B, Kittles, R A, Hughes Halbert, C, Sucheston-Campbell, L E, Yates, C & Campbell, M J 2023, ' African American prostate cancer displays quantitatively distinct vitamin D receptor cistrome-transcriptome relationships regulated by BAZ1A ', Cancer Research Communications, vol. 3, no. 4, pp. 621-639 . https://doi.org/10.1158/2767-9764.crc-22-0389

African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses in European American (EA) and AA prostate ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632bca3c74f2fc49d513601216c48c53
https://doi.org/10.1158/2767-9764.crc-22-0389

Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry

Autor: Jason A. White, Ernest T. Kaninjing, Kayode A. Adeniji, Paul Jibrin, John O. Obafunwa, Chidiebere N. Ogo, Faruk Mohammed, Ademola Popoola, Omolara A. Fatiregun, Olabode P. Oluwole, Balasubramanyam Karanam, Isra Elhussin, Stefan Ambs, Wei Tang, Melissa Davis, Paz Polak, Moray J. Campbell, Kathryn R. Brignole, Solomon O. Rotimi, Windy Dean-Colomb, Folake T. Odedina, Damali N. Martin, Clayton Yates

Publikováno v: Cancer Research Communications. 2:1005-1016

In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to compare genomic mutations with African American (AA) and European Ameri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f573dda185aedfe8b7aa7c08f6b5dbcd
https://doi.org/10.1158/2767-9764.crc-22-0136

Supplementary Figure 6 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Autor: Moray J. Campbell, Clayton Yates, Lara E. Sucheston-Campbell, Chanita Hughes Halbert, Rick A. Kittles, Melissa B. Davis, Larisa Nonn, Adam R. Murphy, Solomon O. Rotimi, Isaacson B. Adelani, Gary Hardiman, Rebecca Morgan, Honghe Wang, Balasubramanyam Karanam, Isra Elhussin, Mark D. Long, Hsu-Chang Wu, Hedieh Jafari, Jaimie S. Gray, Hancong Tang, Jason White, Sajad A. Wani, Shahid Hussain, Manjunath Siddappa

SF_6 RNA-Seq PCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad75ffe1ef0920b81a93edcda62afd22
https://doi.org/10.1158/2767-9764.22652007.v1