Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Balamurugan Dhayalan"'
Autor:
Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants
Externí odkaz:
https://doaj.org/article/ac8abdb348a7445ab68c20aba3dbef24
Autor:
Yanwu Yang, Michael D. Glidden, Balamurugan Dhayalan, Alexander N. Zaykov, Yen-Shan Chen, Nalinda P. Wickramasinghe, Richard D. DiMarchi, Michael A. Weiss
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated mutant INS-gene induced diabetes of the young (MIDY). In our first study (previous article in this issue), we described a one-disulfide peptide mode
Externí odkaz:
https://doaj.org/article/81bdb69b388b4048aa3b5feb43d1bcd4
Autor:
Mark A. Jarosinski, Balamurugan Dhayalan, Yen-Shan Chen, Deepak Chatterjee, Nicolás Varas, Michael A. Weiss
Publikováno v:
Molecular Metabolism, Vol 52, Iss , Pp 101325- (2021)
Background: The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide ch
Externí odkaz:
https://doaj.org/article/934701eebaff4526bc2d5c33215bdbfa
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene (INS). Such mutations cause pancreatic β-cell dysfunction due to toxic misfolding of a mutant proinsulin
Externí odkaz:
https://doaj.org/article/95c62dc333b04eddbb9d345b29c3e2b8
Autor:
Anoop Arunagiri, Peter Arvan, Billy Tsai, Michael A. Weiss, Anis Hassan, Leena Haataja, Ming Liu, Balamurugan Dhayalan, Kaitlin Regan
Publikováno v:
Cellular and Molecular Life Sciences
A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including formation of the Cys(B19)–Cys(A20) “interchain” disulfide bond, facilitating formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48895c1d89b88134df0a713900dad9b1
http://europepmc.org/articles/PMC8316239
http://europepmc.org/articles/PMC8316239
Autor:
Krystel El Hage, Nelson B. Phillips, Yen-Shan Chen, Balamurugan Dhayalan, Jonathan Whittaker, Kelley Carr, Linda Whittaker, Manijeh H. Phillips, Faramarz Ismail-Beigi, Markus Meuwly, Michael A. Weiss
The utility of halogenation in protein design is investigated by a combination of quantitative atomistic simulations and experiment. The approach is applied to insulin, a small, therapeutically relevant domain amenable to simulation and semi-synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7b5e6bc8c26a2edb3296decfd2c8a1d
https://doi.org/10.1101/2022.07.25.501420
https://doi.org/10.1101/2022.07.25.501420
Autor:
Deepak Chatterjee, Mark A. Jarosinski, Balamurugan Dhayalan, Michael A. Weiss, Nischay K. Rege
Publikováno v:
Diabetologia
Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood glucose concentration above or below the therapeutic range (hyper- or hypoglycaemia). To mitigate acute and chronic risks of such excursions, glucose-responsive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2225e21e72676d79f8bb4bfabbac9bb
https://doi.org/10.1007/s00125-021-05422-6
https://doi.org/10.1007/s00125-021-05422-6
Autor:
Pamela Itkin-Ansari, Peter Arvan, Nalinda P. Wickramasinghe, Saiful A. Mir, Arfah Anjum, Michael A. Weiss, Xin Li, Leena Haataja, Yi Xiong, Nischay Rege, Li Lv, Wei Chen, David A. Ostrov, Randal J. Kaufman, Balamurugan Dhayalan, Rachel Madley, Dennis Larkin, Ming Liu, Jinhong Sun
Publikováno v:
Diabetes. 69:954-964
Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant INS gene–induced diabetes of youth (MIDY). How these abnormal interactions are initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2e6fa1101a6b91c5b06ef2264636ac
https://doi.org/10.2337/db19-1106
https://doi.org/10.2337/db19-1106
Autor:
Balamurugan Dhayalan, Weiss Michael
Publikováno v:
Current diabetes reportsPapers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance. 22(2)
Diabetes mellitus (DM) due to toxic misfolding of proinsulin variants provides a monogenic model of endoplasmic reticulum (ER) stress. The mutant proinsulin syndrome (also designated MIDY; Mutant INS-gene-induced Diabetes of Youth or Maturity-onset d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0610223aee3c27d081a233573276084a
https://pubmed.ncbi.nlm.nih.gov/35119630
https://pubmed.ncbi.nlm.nih.gov/35119630
Autor:
Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
Publikováno v:
Frontiers in endocrinology. 13
The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designatedmutant INS-gene induced diabetes of the young(MIDY), this syndrome defines molecular determinants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76981e7bf5dc8d1ca68ff3e3d55e6c55
https://pubmed.ncbi.nlm.nih.gov/35299972
https://pubmed.ncbi.nlm.nih.gov/35299972