Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Balaguru Ravikumar"'
Autor:
Paschalis Athanasiadis, Balaguru Ravikumar, Richard J.R. Elliott, John C. Dawson, Neil O. Carragher, Paul A. Clemons, Timothy Johanssen, Daniel Ebner, Tero Aittokallio
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107209- (2023)
Summary: Designing a targeted screening library of bioactive small molecules is a challenging task since most compounds modulate their effects through multiple protein targets with varying degrees of potency and selectivity. We implemented analytic p
Externí odkaz:
https://doaj.org/article/1cefd29b3ccb49cbab7215e3ecc6518e
Autor:
Anna Cichońska, Balaguru Ravikumar, Robert J. Allaway, Fangping Wan, Sungjoon Park, Olexandr Isayev, Shuya Li, Michael Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I. Wells, Timothy M. Willson, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, Tudor I. Oprea, Avner Schlessinger, David H. Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelera
Externí odkaz:
https://doaj.org/article/f21e267a1ae047ee9c1ecdf221b76214
Autor:
Anna Cichonska, Balaguru Ravikumar, Elina Parri, Sanna Timonen, Tapio Pahikkala, Antti Airola, Krister Wennerberg, Juho Rousu, Tero Aittokallio
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005678 (2017)
Due to relatively high costs and labor required for experimental profiling of the full target space of chemical compounds, various machine learning models have been proposed as cost-effective means to advance this process in terms of predicting the m
Externí odkaz:
https://doaj.org/article/7279e5f8bd5b43b087551e17292e5595
Autor:
Carmen Al-Masri, Francesco Trozzi, Marcel Patek, Anna Cichońska, Balaguru Ravikumar, Rayees Rahman
Protein kinases are a family of signalling proteins, crucial for maintaining cellular homeostasis. When dysregulated, kinases drive the pathogenesis of several diseases, and are thus one of the largest target categories for drug discovery. Kinase act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d879c79eebbc4b508236b8fb9367fa7
https://doi.org/10.1101/2022.12.02.518928
https://doi.org/10.1101/2022.12.02.518928
Autor:
Timothy Johanssen, Daniel Ebner, Balaguru Ravikumar, Paschalis Athanasiadis, Tero Aittokallio, Paul A. Clemons, Neil O. Carragher
Designing a focused compound screening library of bioactive small molecules is a challenging task since many compounds modulate their effects through multiple protein targets with various degrees of potency and selectivity. We describe here several a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748c8dfc9e6fb52c123403da6481c113
https://doi.org/10.1101/2020.11.30.403329
https://doi.org/10.1101/2020.11.30.403329
Autor:
Olexandr Isayev, David H. Drewry, Michael Mason, Jaewoo Kang, Andrew Lamb, Minji Jeon, Gustavo Stolovitzky, Sunkyu Kim, Carrow I. Wells, Robert J. Allaway, Tudor I. Oprea, Shuya Li, Stephen J. Capuzzi, Anna Cichonska, Kristen K. Dang, Tero Aittokallio, Timothy M. Willson, Ziaurrehman Tanoli, Krister Wennerberg, Sungjoon Park, Justin Guinney, Gregory Koytiger, Fangping Wan, Jianyang Zeng, Balaguru Ravikumar, Mariya Popova, Avner Schlessinger
Despite decades of intensive search for compounds that modulate the activity of particular targets, there are currently small-molecules available only for a small proportion of the human proteome. Effective approaches are therefore required to map th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190ce84be10270927d9a2faa3fe5cb07
https://doi.org/10.1101/2019.12.31.891812
https://doi.org/10.1101/2019.12.31.891812
Autor:
Balaguru Ravikumar, Tero Aittokallio
Publikováno v:
Expert Opinion on Drug Discovery. 13:179-192
Polypharmacology has emerged as an essential paradigm for modern drug discovery process. Multiple lines of evidence suggest that agents capable of modulating multiple targets in a selective manner may offer also improved balance between therapeutic e
Autor:
Zaid Alam, Elina Parri, Balaguru Ravikumar, Krister Wennerberg, Tero Aittokallio, Sanna Timonen
Publikováno v:
Cell chemical biology. 26(11)
Owing to the intrinsic polypharmacological nature of most small-molecule kinase inhibitors, there is a need for computational models that enable systematic exploration of the chemogenomic landscape underlying druggable kinome toward more efficient ki
Autor:
Rajendra Prasad, Virander S. Chauhan, Sobhan Sen, Andrew M. Lynn, Neeraj Chauhan, Jyotsna Sharma, Chaitanya Kumar Thota, Indresh Kumar Maurya, Manpreet Kaur Rawal, Sachin Dev Verma, Balaguru Ravikumar
Publikováno v:
Journal of Biological Chemistry. 295:3393
Drug-resistant pathogenic fungi use several families of membrane-embedded transporters to efflux antifungal drugs from the cells. The efflux pump Cdr1 (Candida drug resistance 1) belongs to the ATP-binding cassette (ABC) superfamily of transporters.
Autor:
Alina Malyutina, Jing Tang, Ziaurrehman Tanoli, Tero Aittokallio, Alok Jaiswal, Markus Vähä-Koskela, Krister Wennerberg, Zaid Alam, Balaguru Ravikumar
Publikováno v:
Tanoli, Z R, Alam, Z, Vähä-Koskela, M, Ravikumar, B, Malyutina, A, Jaiswal, A, Tang, J, Wennerberg, K & Aittokallio, T 2018, ' Drug Target Commons 2.0 : a community platform for systematic analysis of drug-target interaction profiles ', Database: The Journal of Biological Databases and Curation, vol. 2018, no. 2018, bay083, pp. 1-13 . https://doi.org/10.1093/database/bay083
Database
Database
Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles. End users can sear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73e0b8199a4ef8c6c5536779de1e61a
https://curis.ku.dk/portal/da/publications/drug-target-commons-20(6f1ba583-1ae2-4c53-85e0-c89ca2d81339).html
https://curis.ku.dk/portal/da/publications/drug-target-commons-20(6f1ba583-1ae2-4c53-85e0-c89ca2d81339).html