Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions

Autor: Sergio Villatoro, Clara Mayo‐de‐las‐Casas, Núria Jordana‐Ariza, Santiago Viteri‐Ramírez, Mónica Garzón‐Ibañez, Irene Moya‐Horno, Beatriz García‐Peláez, María González‐Cao, Umberto Malapelle, Ariadna Balada‐Bel, Alejandro Martínez‐Bueno, Raquel Campos, Noemí Reguart, Margarita Majem, Remei Blanco, Ana Blasco, María J. Catalán, Xavier González, Giancarlo Troncone, Niki Karachaliou, Rafael Rosell, Miguel A. Molina‐Vila

Publikováno v: Molecular Oncology, Vol 13, Iss 12, Pp 2633-2645 (2019)

Many advanced cases of cancer show central nervous system, pleural, or peritoneal involvement. In this study, we prospectively analyzed if cerebrospinal fluid (CSF), pleural effusion (PE), and/or ascites (ASC) can be used to detect driver mutations a

Externí odkaz: https://doaj.org/article/768780ab545245d49c5080fab9f9fe1b

Evolution and Clinical Impact of EGFR Mutations in Circulating Free DNA in the BELIEF Trial

Autor: Niki Karachaliou, Zoi Tsourti, Bartomeu Massuti, Santiago Ponce Aix, Martin Früh, Miklos Pless, Paolo Bidoli, Núria Jordana-Ariza, Ariadna Balada-Bel, H. Roschitzki-Voser, Enriqueta Felip, Solange Peters, Mónica Garzón-Ibáñez, Roswitha Kammler, Ramon Palmero, Sinead Cuffe, Clara Mayo-de-las-Casas, Rafael Rosell, Sanjay Popat, Enric Carcereny, M.A. Molina-Vila, Oliver Gautschi, Beatriz García-Peláez, Rolf A. Stahel, Urania Dafni, Alessandra Curioni Fontecedro

Publikováno v: Journal of Thoracic Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
JOURNAL OF THORACIC ONCOLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Introduction: Longitudinal evaluation of mutations in blood samples was a prespecified secondary objective in the BELIEF trial of erlotinib and bevacizumab in advanced EGFR-positive NSCLC. Here, we report the testing results and explore the correlati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994673a7e864203d23813318e7ec156a
http://hdl.handle.net/10281/260723

Evolution and Clinical Impact of EGFR Mutations in Circulating Free DNA in the BELIEF Trial

Autor: Molina-Vila, M.-A. Stahel, R.A. Dafni, U. Jordana-Ariza, N. Balada-Bel, A. Garzón-Ibáñez, M. García-Peláez, B. Mayo-de-las-Casas, C. Felip, E. Curioni Fontecedro, A. Gautschi, O. Peters, S. Massutí, B. Palmero, R. Ponce Aix, S. Carcereny, E. Früh, M. Pless, M. Popat, S. Cuffe, S. Bidoli, P. Kammler, R. Roschitzki-Voser, H. Tsourti, Z. Karachaliou, N. Rosell, R.

Introduction: Longitudinal evaluation of mutations in blood samples was a prespecified secondary objective in the BELIEF trial of erlotinib and bevacizumab in advanced EGFR-positive NSCLC. Here, we report the testing results and explore the correlati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::a086afd5b5e10432a3da1ab7c157668f
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3104717

An update on liquid biopsy analysis for diagnostic and monitoring applications in non-small cell lung cancer

Autor: Miguel Angel Molina-Vila, Niki Karachaliou, Umberto Malapelle, Clara Mayo-de-las-Casas, Mónica Garzón Ibañez, Giancarlo Troncone, Ariadna Balada-Bel, Beatriz García-Peláez, Núria Jordana-Ariza, Sergio Villatoro, Rafael Rosell

Publikováno v: Expert Review of Molecular Diagnostics. 18:35-45

Collection of tumor samples is not always feasible in non-small cell lung cancer (NSCLC) patients, and circulating free DNA (cfDNA) extracted from blood represents a viable alternative. Different sensitive platforms have been developed for genetic cf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21cfc02d6b2056e6e59a99cfb058843
https://doi.org/10.1080/14737159.2018.1407243

Annotating the next generation sequencing report

Autor: Mónica Garzón-Ibáñez, Beatriz García-Peláez, Miguel Angel Molina-Vila, Núria Jordana-Ariza, Clara Mayo-de-las-Casas, Rafael Rosell, Ariadna Balada-Bel

Publikováno v: Precision Cancer Medicine. 3:6-6

With the advent of precision oncology, the number of genetic alterations to be tested in tumor biopsies has significantly increased. Consequently, many clinical laboratories are incorporating multiplexed techniques, such as next generation sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5d11f41d78f994d9f6f5f73de732e64
https://doi.org/10.21037/pcm.2019.11.02