Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Balachandra Chenna"'
Autor:
Kim M Keeling, Dan Wang, Yanying Dai, Srinivasan Murugesan, Balachandra Chenna, Jeremy Clark, Valery Belakhov, Jeyakumar Kandasamy, Sadanandan E Velu, Timor Baasov, David M Bedwell
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60478 (2013)
Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression o
Externí odkaz:
https://doaj.org/article/65b49f1f65d24a4cb10e23580a3d869b
Autor:
Sunil Sudarshan, Karen Block, Shi Wei, Sejong Bae, Lining Guo, Teresa L. Johnson-Pais, Qiuhua Li, Robert J. Mishur, Shane L. Rea, Balachandra Chenna, Shilpa Dutta, Sadanan Velu, Richard Kirkman, Arindam P. Ghosh, Eun-Young Kho, Vishwas Parekh, Daniel Benson, Jubilee Tan, Dinesh Rakheja, Carolina B. Livi, Eun-Hee Shim
Supplementary Table 2. VHL Genotyping in High L-2HG Tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53418bb2aac21fd11aff35ef194b82fa
https://doi.org/10.1158/2159-8290.22530497.v1
https://doi.org/10.1158/2159-8290.22530497.v1
Autor:
Sunil Sudarshan, Karen Block, Shi Wei, Sejong Bae, Lining Guo, Teresa L. Johnson-Pais, Qiuhua Li, Robert J. Mishur, Shane L. Rea, Balachandra Chenna, Shilpa Dutta, Sadanan Velu, Richard Kirkman, Arindam P. Ghosh, Eun-Young Kho, Vishwas Parekh, Daniel Benson, Jubilee Tan, Dinesh Rakheja, Carolina B. Livi, Eun-Hee Shim
Supplementary Figure 2. HK-2 and HEK293 cells were transiently cotransfected with the indicated siRNA and TET1 cDNA. Protein lysates were harvested and immunoblotted for the indicated proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620e56198e38862572feb4d6df9d4fdc
https://doi.org/10.1158/2159-8290.22530509.v1
https://doi.org/10.1158/2159-8290.22530509.v1
Autor:
Sunil Sudarshan, Karen Block, Shi Wei, Sejong Bae, Lining Guo, Teresa L. Johnson-Pais, Qiuhua Li, Robert J. Mishur, Shane L. Rea, Balachandra Chenna, Shilpa Dutta, Sadanan Velu, Richard Kirkman, Arindam P. Ghosh, Eun-Young Kho, Vishwas Parekh, Daniel Benson, Jubilee Tan, Dinesh Rakheja, Carolina B. Livi, Eun-Hee Shim
Supplementary Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ead0c4b3d1acc5443bb885ed733849
https://doi.org/10.1158/2159-8290.22530503.v1
https://doi.org/10.1158/2159-8290.22530503.v1
Autor:
Sunil Sudarshan, Karen Block, Shi Wei, Sejong Bae, Lining Guo, Teresa L. Johnson-Pais, Qiuhua Li, Robert J. Mishur, Shane L. Rea, Balachandra Chenna, Shilpa Dutta, Sadanan Velu, Richard Kirkman, Arindam P. Ghosh, Eun-Young Kho, Vishwas Parekh, Daniel Benson, Jubilee Tan, Dinesh Rakheja, Carolina B. Livi, Eun-Hee Shim
Supplementary Table 1. Clinical Data on Tumor Samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148350230be45fe065faa29aca141189
https://doi.org/10.1158/2159-8290.22530500.v1
https://doi.org/10.1158/2159-8290.22530500.v1
Autor:
Sunil Sudarshan, Karen Block, Shi Wei, Sejong Bae, Lining Guo, Teresa L. Johnson-Pais, Qiuhua Li, Robert J. Mishur, Shane L. Rea, Balachandra Chenna, Shilpa Dutta, Sadanan Velu, Richard Kirkman, Arindam P. Ghosh, Eun-Young Kho, Vishwas Parekh, Daniel Benson, Jubilee Tan, Dinesh Rakheja, Carolina B. Livi, Eun-Hee Shim
Supplementary Figure 1. A498 cells were stable transduced with the indicated construct. Protein lysates were harvested and immunoblotted for the indicated proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee17d282f472f31b0a1acd8b5c19fc2
https://doi.org/10.1158/2159-8290.22530512.v1
https://doi.org/10.1158/2159-8290.22530512.v1
Autor:
Sunil Sudarshan, Karen Block, Shi Wei, Sejong Bae, Lining Guo, Teresa L. Johnson-Pais, Qiuhua Li, Robert J. Mishur, Shane L. Rea, Balachandra Chenna, Shilpa Dutta, Sadanan Velu, Richard Kirkman, Arindam P. Ghosh, Eun-Young Kho, Vishwas Parekh, Daniel Benson, Jubilee Tan, Dinesh Rakheja, Carolina B. Livi, Eun-Hee Shim
Supplementary Figure 3. HEK293 cells were transiently transfected with either CV or L2HGDH cDNA and TET1 cDNA. Protein lysates were harvested and immunoblotted for the indicated proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741360692289275d4bc3a015a80246ae
https://doi.org/10.1158/2159-8290.22530506.v1
https://doi.org/10.1158/2159-8290.22530506.v1
Autor:
Aleksandra Drelich, Miriam A. Giardini, Pavla Fajtová, Drake M. Mellott, Vivian Hook, Thomas D. Meek, Jason C. Hsu, Demetrios H. Kostomiris, Aaron F. Carlin, Frank M. Raushel, Klaudia I. Kocurek, Jair L. Siqueira-Neto, Zane W. Taylor, Anthony J. O’Donoghue, Felix W Frueh, Jiyun Zhu, Ardala Katzfuss, Chien Te K. Tseng, Sungjun Beck, Hong Wang, Brett L. Hurst, Laura Beretta, Ken Hirata, James H. McKerrow, Alex E. Clark, Linfeng Li, Daniel C Maneval, Danielle E. Skinner, Balachandra Chenna, Vivian Tat, Michael C Yoon
Publikováno v:
ACS Chemical Biology. 16:642-650
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SAR
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote