Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Balachandra Bandodkar"'
Publikováno v:
Applied Sciences, Vol 10, Iss 16, p 5704 (2020)
After several years of limited success, an effective regimen for the treatment of both drug-sensitive and multiple-drug-resistant tuberculosis is in place. However, this success is still incomplete, as we need several more novel combinations to treat
Externí odkaz:
https://doaj.org/article/9cbedacd6a4946b6a4537577e9cbf599
Autor:
Vaishali Humnabadkar, Claire Sadler, Tanjore S. Balganesh, Prakash Vachaspati, Disha Awasthy, Manoranjan Panda, Mick D. Fellows, Parvinder Kaur, Stewart T. Cole, Florence Pojer, Vasan K. Sambandamurthy, João Neres, Sreevalli Sharma, V. Balasubramanian, Kannan Murugan, Meenakshi Mallya, Suresh Rudrapatna, Balachandra Bandodkar, Sudhir Landge, Bheemarao G. Ugarkar, Jyothi Mahadevaswamy, Kavitha Nagalapur, Amrita B. Mullick, Vasanthi Ramachandran, Anirban Ghosh, Venkita Subbulakshmi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7694-7710
We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition o
Publikováno v:
Applied Sciences, Vol 10, Iss 5704, p 5704 (2020)
After several years of limited success, an effective regimen for the treatment of both drug-sensitive and multiple-drug-resistant tuberculosis is in place. However, this success is still incomplete, as we need several more novel combinations to treat
Autor:
Rajesh Kalkhambkar, Bheemarao G. Ugarkar, Jon Read, Martin Vogtherr, Beena Paul, Swati Prasad, Adrian Liam Gill, Shantika Bhat, Helen H.J. McMiken, Maruti Naik, Jyothi Bhat, Julie A. Tucker, Kevin J. Embrey, Begur Vasanthkumar Varun, Balachandra Bandodkar, Rani Menon, Syeed Hussein, Janani Venkatraman, Kannan Murugan, Harini Iyer, Anandkumar Raichurkar, Manoranjan Panda
Publikováno v:
Journal of Medicinal Chemistry. 58:753-766
M. tuberculosis thymidylate kinase (Mtb TMK) has been shown in vitro to be an essential enzyme in DNA synthesis. In order to identify novel leads for Mtb TMK, we performed a high throughput biochemical screen and an NMR based fragment screen through
Autor:
Nilanjana Roy Choudhury, Balachandra Bandodkar, Vasanthi Ramachandran, Ramachandran Sreekanth A, Chaitanya Kumar Kedari, Kakoli Mukerjee, Parvinder Kaur, Manoranjan Panda, Supreeth Guptha, Sreevalli Sharma, Subramanyam J. Tantry
Publikováno v:
ACS Medicinal Chemistry Letters. 5:491-495
A whole cell based screening effort on a focused library from corporate collection resulted in the identification of biarylmethoxy nicotinamides as novel inhibitors of M. tuberculosis (Mtu) H37Rv. The series exhibited tangible structure–activity re
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Autor:
Eknath Bellale, Maruti Naik, Varun VB, Anisha Ambady, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Parvinder Kaur, Robert McLaughlin, James Whiteaker, Sapna Morayya, Supreeth Guptha, Sreevalli Sharma, Anandkumar Raichurkar, Disha Awasthy, Vijayshree Achar, Prakash Vachaspati, Balachandra Bandodkar, Manoranjan Panda, Monalisa Chatterji
Publikováno v:
Journal of medicinal chemistry. 57(15)
Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize th
Autor:
David Waterson, Stefan Kavanagh, V. Balasubramanian, Vijender Panduga, Francisco-Javier Gamo, María Santos Martínez, Shahul Hameed P, Vinayak Hosagrahara, María Belén Jiménez-Díaz, Shubhada Barde, Kakoli Mukherjee, Sandra Duffy, Santiago Ferrer, Vikas Patil, Balachandra Bandodkar, Ramachandran Sreekanth A, K.R. Prabhakar, Suresh Rudrapatna, Praveena Manjrekar, Iñigo Angulo-Barturen, Pravin Iyer, Vasan K. Sambandamurthy, Nikhil Rautela, Pamela Magistrado, Dyann F. Wirth, Sowmya Bharath, Chandan Narayan, Sapna Morayya, Murugan Chinnapattu, Pavithra Viswanath, Anandkumar Raichurkar, Krishna Koushik, Jitender Reddy, Vicky M. Avery, Achyut Sinha, Amanda K. Lukens, Disha Awasthy, Shridhar Narayanan, Laura M. Sanz, Gajanan Shanbag, Sandesh Jatheendranath, Abhishek Srivastava, Ramanatha Saralaya
Publikováno v:
Journal of medicinal chemistry. 57(13)
Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chemi
Autor:
Vikas Shinde, Vasan K. Sambandamurthy, Sowmya Bharath, Ragini Singh, Sudhir Landge, Sreenivasaiah Menasinakai, Kakoli Mukherjee, Anirban Ghosh, Anandkumar Raichurkar, Jyothi Bhat, C. Bjorkelid, Vikas Patil, B. K. Kishore Reddy, Naveen Kumar, Aishwarya Sundaram, Balachandra Bandodkar, Kaveri Das, Krishnan Malolanarasimhan, Sudha Ravishankar, Vasanthi Ramachandran, T. Alwyn Jones, Subramanyam J. Tantry, Parvinder Kaur, Ragadeepthi Tunduguru, Anisha Ambady, Naina Vinay Mudugal, Kale Manoj Ganpat
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4f3e4256aa802b61732e793f93831e
https://europepmc.org/articles/PMC4068421/
https://europepmc.org/articles/PMC4068421/
Autor:
R. Kiplin Guy, Santiago Ferrer-Bazaga, Tanya Parkinson, Iñigo Angulo-Barturen, Francisco Javier Gamo-Benito, Michele Connelly, Sandra Duffy, Julie Lotharius, Julie Clark, Balachandra Bandodkar, Nikhil Rautela, Jörg J. Möhrle, Pavithra Viswanath, Timothy N. C. Wells, Sowmya Bharath, Vicky M. Avery
Publikováno v:
Malaria Journal
Background Repositioning of existing drugs has been suggested as a fast track for developing new anti-malarial agents. The compound libraries of GlaxoSmithKline (GSK), Pfizer and AstraZeneca (AZ) comprising drugs that have undergone clinical studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca663113f92c210767ce7fb50e7460e9
https://hdl.handle.net/10016/37901
https://hdl.handle.net/10016/37901