Zobrazeno 1 - 10
of 452
pro vyhledávání: '"Balázs Győrffy"'
Autor:
Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Bernhard Zdársky, Kerstin Heindl, Stefanie Weiss, Thomas Eder, Sayantanee Dutta, Uwe Graichen, Sascha Klee, Omar Sharif, Rotraud Wieser, Balázs Győrffy, Valeria Poli, Emilio Casanova, Heinz Sill, Florian Grebien, Dagmar Stoiber
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-12 (2024)
Abstract Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in two distinct alternatively spliced isoforms, the full-length isoform STAT3α and the C-term
Externí odkaz:
https://doaj.org/article/fa3588b01db84ae4a00ac9b61c021e7a
Autor:
María del Mar Noblejas-López, Elena García-Gil, Pedro Pérez-Segura, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Regulatory T cells (Tregs) is a subtype of CD4+ T cells that produce an inhibitory action against effector cells. In the present work we interrogated genomic datasets to explore the transcriptomic profile of breast tumors with high expressio
Externí odkaz:
https://doaj.org/article/74224a059ba148d49dfab9e6ca39f072
Autor:
Agnieszka Witalisz-Siepracka, Clio-Melina Denk, Bernhard Zdársky, Lorenz Hofmann, Sophie Edtmayer, Theresa Harm, Stefanie Weiss, Kerstin Heindl, Manuel Hessenberger, Sabrina Summer, Sayantanee Dutta, Emilio Casanova, Gerald J. Obermair, Balázs Győrffy, Eva Maria Putz, Heinz Sill, Dagmar Stoiber
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Acute myeloid leukemia (AML) is a heterogenous disease characterized by the clonal expansion of myeloid progenitor cells. Despite recent advancements in the treatment of AML, relapse still remains a significant challenge, necessitating the developmen
Externí odkaz:
https://doaj.org/article/cf2694443fe34e35bace14518f251243
Autor:
Leticia Szadai, Aron Bartha, Indira Pla Parada, Alexandra I.T. Lakatos, Dorottya M.P. Pál, Anna Sára Lengyel, Natália Pinto de Almeida, Ágnes Judit Jánosi, Fábio Nogueira, Beata Szeitz, Viktória Doma, Nicole Woldmar, Jéssica Guedes, Zsuzsanna Ujfaludi, Zoltán Gábor Pahi, Tibor Pankotai, Yonghyo Kim, Balázs Győrffy, Bo Baldetorp, Charlotte Welinder, A. Marcell Szasz, Lazaro Betancourt, Jeovanis Gil, Roger Appelqvist, Ho Jeong Kwon, Sarolta Kárpáti, Magdalena Kuras, Jimmy Rodriguez Murillo, István Balázs Németh, Johan Malm, David Fenyö, Krzysztof Pawłowski, Peter Horvatovich, Elisabet Wieslander, Lajos V. Kemény, Gilberto Domont, György Marko-Varga, Aniel Sanchez
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionWhile Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI ther
Externí odkaz:
https://doaj.org/article/fe95ef6a509c4265b300a1ff4e58f88f
Publikováno v:
Integrative Cancer Therapies, Vol 23 (2024)
Hyperthermia, the raising of tumor temperature (≥39°C), holds great promise as an adjuvant treatment for cancer therapy. This review focuses on 2 key aspects of hyperthermia: its molecular and cellular effects and its impact on the immune system.
Externí odkaz:
https://doaj.org/article/a76e84f1e6d04228ae58f475909820fa
Autor:
Balázs Győrffy
Publikováno v:
The Innovation, Vol 5, Iss 3, Pp 100625- (2024)
Identifying genes with prognostic significance that can act as biomarkers in solid tumors can help stratify patients and uncover novel therapy targets. Here, our goal was to expand our previous ranking analysis of survival-associated genes in various
Externí odkaz:
https://doaj.org/article/6614641b5c4f4029abdcb591d8ded6ec
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract ASPP1 (PPP1R13B) belongs to a family of p53-binding proteins and enhances apoptosis by stimulation of p53-transactivation of selected proapoptotic target genes. It is preferentially expressed in hematopoietic stem cells (HSC) and together wi
Externí odkaz:
https://doaj.org/article/245785d349884613ae1bfd8cd977e713
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract A growing interest for demonstrating prestige and status of higher education institutions has spurred the establishment of several international ranking systems. A major percentage of these rankings include parameters related to scientific p
Externí odkaz:
https://doaj.org/article/85c45de8172e43a781ead9ff40a2258d
Autor:
Máté Posta, Balázs Győrffy
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1479-1491 (2023)
Abstract Pancreatic adenocarcinoma remains a leading cause of cancer‐related deaths. In order to develop appropriate therapeutic and prognostic tools, a comprehensive mapping of the tumor's molecular abnormalities is essential. Here, our aim was to
Externí odkaz:
https://doaj.org/article/178d84bfa2724d8e85447d9b1a89b2dd
Autor:
Adrián Sanvicente García, Manuel Pedregal, Lucía Paniagua-Herranz, Cristina Díaz-Tejeiro, Cristina Nieto-Jiménez, Pedro Pérez Segura, Gyöngyi Munkácsy, Balázs Győrffy, Emiliano Calvo, Víctor Moreno, Alberto Ocaña
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5345 (2024)
The identification of targets that are expressed on the cell membrane is a main goal in cancer research. The Lymphocyte Antigen 6 Family Member G6D (LY6G6D) gene codes for a protein that is mainly present on the surface of colorectal cancer (CRC) cel
Externí odkaz:
https://doaj.org/article/12a3623042cd4919b4effc47d41c292d