Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Balázs, Mihalik"'
Autor:
Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Abstract Background Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the fami
Externí odkaz:
https://doaj.org/article/6f5f47269cee49599dfeeaaaeb8782f6
Publikováno v:
Molecules, Vol 24, Iss 14, p 2546 (2019)
The calcium sensing receptor (CaSR) was first identified in parathyroid glands, and its primary role in controlling systemic calcium homeostasis by the regulation of parathyroid hormone (PTH) secretion has been extensively described in literature. Ad
Externí odkaz:
https://doaj.org/article/2bf9abc745df4545ba368fbfa34bb86d
Autor:
Inna Székács, Nóra Kaszás, Pál Gróf, Katalin Erdélyi, István Szendrő, Balázs Mihalik, Agnes Pataki, Ferenc A Antoni, Emilia Madarász
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81398 (2013)
Optical waveguide lightmode spectroscopic (OWLS) techniques were probed for monitoring ion permeation through channels incorporated into artificial lipid environment. A novel sensor set-up was developed by depositing liposomes or cell-derived membran
Externí odkaz:
https://doaj.org/article/d156618b5c1d475aae8664981e8ddb5f
Autor:
Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461
Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is presented. It details all proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e81d40cbe9c93d9b654557d3afcabe
https://hdl.handle.net/1887/3184413
https://hdl.handle.net/1887/3184413
Autor:
Ferenc A. Antoni, Szabolcs Udvari, Katalin Megyeri, Ágnes Pataki, Istvan Gacsalyi, Balázs Mihalik, Krisztina Moricz, Gabor Gigler, Adrienn Pálvölgyi
Publikováno v:
Neuropharmacology. 128:408-415
Gamma-amino butyric acid (GABA) is an abundant neurotransmitter in the CNS. GABAergic interneurons orchestrate pyramidal neurons in the cerebral cortex, and thus control learning and memory. Ionotropic receptors for GABA (GABAAR) are heteropentameric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8efb0bb58154827248130c029122f447
https://doi.org/10.1016/j.neuropharm.2017.10.042
https://doi.org/10.1016/j.neuropharm.2017.10.042
Autor:
Lori-An Etherington, Adrienn Pálvölgyi, Katalin Pallagi, Ferenc A. Antoni, Adam R. Brown, József Barkóczy, Delia Belelli, Olivia Monteiro, Szabolcs Kertesz, Ben G. Gunn, Michael Spedding, Balázs Mihalik, Istvan Gacsalyi, István Ling, Matthew R. Livesey, Péter Varga, Jeremy J. Lambert
Publikováno v:
Etherington, L-A, Mihalik, B, Pálvölgyi, A, Ling, I, Pallagi, K, Kertész, S, Varga, P, Gunn, B, Brown, A, Livesey, M, Monteiro, O, Belelli, D, Barkóczy, J, Spedding, M, Gacsályi, I, Antoni, F & Lambert, J 2017, ' Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent. ', Neuropharmacology, pp. 30379-9 . https://doi.org/10.1016/j.neuropharm.2017.08.012
In the mammalian central nervous system (CNS) GABAA receptors (GABAARs) mediate neuronal inhibition and are important therapeutic targets. GABAARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression of 20–30 GABAAR subtypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42c09c14917f391a41a6b52b26e2be7
https://doi.org/10.1016/j.neuropharm.2017.08.012
https://doi.org/10.1016/j.neuropharm.2017.08.012
Autor:
Tamás A. Martinek, Istvan Gacsalyi, Katalin Megyeri, Ferenc Bogár, Adrienn Pálvölgyi, István Ling, Ferenc A. Antoni, Balázs Mihalik, Ferenc Bartha, József Barkóczy
Publikováno v:
European Journal of Pharmacology. 798:129-136
The neurotransmitter γ-amino butyric acid (GABA) has a fundamental role in CNS function and ionotropic (GABAA) receptors that mediate many of the actions of GABA are important therapeutic targets. This study reports the mechanism of action of novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92fa262ada488896cbdee7d76040328d
https://doi.org/10.1016/j.ejphar.2017.01.033
https://doi.org/10.1016/j.ejphar.2017.01.033
Publikováno v:
Molecules
Molecules, Vol 24, Iss 14, p 2546 (2019)
Molecules, Vol 24, Iss 14, p 2546 (2019)
The calcium sensing receptor (CaSR) was first identified in parathyroid glands, and its primary role in controlling systemic calcium homeostasis by the regulation of parathyroid hormone (PTH) secretion has been extensively described in literature. Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47436640d714c9be8c6fff6f11c0f49d
Autor:
Julianna Kobolák, Kinga Molnár, Jørgen E. Nielsen, Hasan X. Avci, Andras Dinnyes, Bjørn Holst, Lajos László, István Bock, Annamária Téglási, Poul Hyttel, Kristine K. Freude, Anna Ochalek, Maria Lo Giudice, Abinaya Chandrasekaran, Zsuzsanna Táncos, Balázs Mihalik
Publikováno v:
Alzheimer's Research & Therapy
Alzheimers Research & Therapy
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Ochalek, A, Mihalik, B, Avci, H X, Chandrasekaran, A, Téglási, A, Bock, I, Giudice, M L, Táncos, Z, Molnár, K, László, L, Nielsen, J E, Holst, B, Freude, K, Hyttel, P, Kobolák, J & Dinnyés, A 2017, ' Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation ', Alzheimer's Research and Therapy, vol. 9, no. 1, 90 . https://doi.org/10.1186/s13195-017-0317-z
Alzheimers Research & Therapy
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Ochalek, A, Mihalik, B, Avci, H X, Chandrasekaran, A, Téglási, A, Bock, I, Giudice, M L, Táncos, Z, Molnár, K, László, L, Nielsen, J E, Holst, B, Freude, K, Hyttel, P, Kobolák, J & Dinnyés, A 2017, ' Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation ', Alzheimer's Research and Therapy, vol. 9, no. 1, 90 . https://doi.org/10.1186/s13195-017-0317-z
Background: Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b43395a22a2174b4f04657b84fe316a
Autor:
Gyula Simig, Adrienn Pálvölgyi, Szabolcs Kertesz, István Ling, Istvan Gacsalyi, Éva Szabó, Attila Gaál, Michael Spedding, Balázs Mihalik, Gábor Szénási, Delia Belelli, Gabor Gigler, Jeremy J. Lambert, Péter Kiricsi, Lori An Etherington, Balázs Volk, József Barkóczy, Katalin Pallagi, Ferenc A. Antoni, György Lévay, Gábor Kapus, Lilla Papp, Laszlo G. Harsing
Publikováno v:
European Journal of Pharmacology. 764:497-507
Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to produce compounds that potently inhibited the action of GABA on heterologously expressed GABAA receptors con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b449a320bd028d64481cb4dcfd24adf2
https://doi.org/10.1016/j.ejphar.2015.07.005
https://doi.org/10.1016/j.ejphar.2015.07.005