Einfluss der antithrombozytären Therapie auf den klinischen Verlauf der Steatosis hepatis

Autor: Baku, Florian

Die NAFLD stellt die häufigste chronische Lebererkrankung in Industrienationen dar (Loomba and Sanyal, 2013). Neben diätetischen Therapiemaßnahmen sind medikamentöse Therapieoptionen dringend erforderlich. Die Arbeit beschäftigt sich hierbei mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______707::cbc44348fd374cdf3322cdb6fcc4a689
https://hdl.handle.net/10900/119386

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Autor: Malehmir, Mohsen, Pfister, Dominik, Gallage, Suchira, Szydlowska, Marta, Inverso, Donato, Kotsiliti, Elena, Leone, Valentina, Peiseler, Moritz, Surewaard, Bas G. J., Rath, Dominik, Ali, Adnan, Wolf, Monika Julia, Drescher, Hannah, Healy, Marc E., Dauch, Daniel, Kroy, Daniela, Krenkel, Oliver, Kohlhepp, Marlene, Engleitner, Thomas, Olkus, Alexander, Sijmonsma, Tjeerd, Volz, Julia, Deppermann, Carsten, Stegner, David, Helbling, Patrick, Nombela-Arrieta, César, Rafiei, Anahita, Hinterleitner, Martina, Rall, Marcel, Baku, Florian, Borst, Oliver, Wilson, Caroline L., Leslie, Jack, O’Connor, Tracy, Weston, Christopher J., Chauhan, Abhishek, Adams, David H., Sheriff, Lozan, Teijeiro, Ana, Prinz, Marco, Bogeska, Ruzhica, Anstee, Natasha, Bongers, Malte N., Notohamiprodjo, Mike, Geisler, Tobias, Withers, Dominic J., Ware, Jerry, Mann, Derek A., Augustin, Hellmut G., Vegiopoulos, Alexandros, Milsom, Michael D., Rose, Adam J., Lalor, Patricia F., Llovet, Josep M., Pinyol, Roser, Tacke, Frank, Rad, Roland, Matter, Matthias, Djouder, Nabil, Kubes, Paul, Knolle, Percy A., Unger, Kristian, Zender, Lars, Nieswandt, Bernhard, Gawaz, Meinrad, Weber, Achim, Heikenwalder, Mathias

Publikováno v: Nature Medicine; April 2019, Vol. 25 Issue: 4 p641-655, 15p

Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Autor: Malehmir M; Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland., Pfister D; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Gallage S; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Szydlowska M; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Inverso D; Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany.; European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Kotsiliti E; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.; Institute for Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany., Leone V; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.; Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg, Germany., Peiseler M; Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Surewaard BGJ; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Medical Microbiology, University Medical Center, Utrmeecht, the Netherlands., Rath D; Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University Tübingen, Tübingen, Germany., Ali A; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Wolf MJ; Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland., Drescher H; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Healy ME; Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland., Dauch D; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany.; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen, Germany., Kroy D; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Krenkel O; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Kohlhepp M; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Engleitner T; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Olkus A; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.; Medical Faculty, University of Heidelberg, Heidelberg, Germany., Sijmonsma T; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Volz J; Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Deppermann C; Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Stegner D; Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Helbling P; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Nombela-Arrieta C; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Rafiei A; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Hinterleitner M; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany.; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen, Germany., Rall M; Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University Tübingen, Tübingen, Germany., Baku F; Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University Tübingen, Tübingen, Germany., Borst O; Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University Tübingen, Tübingen, Germany., Wilson CL; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK., Leslie J; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK., O'Connor T; Institute for Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany.; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany., Weston CJ; Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK., Chauhan A; Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK., Adams DH; Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK.; Liver Unit, University Hospitals Birmingham NHS Trust, Birmingham, UK., Sheriff L; Institute for Cardiovascular Sciences, University of Birmingham, Birmingham, UK., Teijeiro A; Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain., Prinz M; Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bogeska R; Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.; DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Anstee N; Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.; DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Bongers MN; Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany., Notohamiprodjo M; Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany., Geisler T; Department of Cardiovascular Medicine, University Hospital, Eberhard Karls University of Tübingen, Tübingen, Germany., Withers DJ; Metabolic Signalling Group, MRC London Institute of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Ware J; Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Mann DA; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK., Augustin HG; Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany.; European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Vegiopoulos A; DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center (DKFZ), Heidelberg, Germany., Milsom MD; Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.; DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Rose AJ; Nutrient Metabolism and Signalling Lab, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, and Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia., Lalor PF; Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK., Llovet JM; Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Liver Cancer Translational Research Laboratory, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain., Pinyol R; Liver Cancer Translational Research Laboratory, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain., Tacke F; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Rad R; Center for Translational Cancer Research (TranslaTUM), Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Matter M; Institute of Pathology, University Hospital of Basel, Basel, Switzerland., Djouder N; Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain., Kubes P; Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Knolle PA; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany., Unger K; Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg, Germany., Zender L; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany.; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen, Germany.; Translational Gastrointestinal Oncology Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Nieswandt B; Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Gawaz M; Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University Tübingen, Tübingen, Germany., Weber A; Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland. achim.weber@usz.ch., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany. heikenwaelder@helmholtz-muenchen.de.; Institute for Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany. heikenwaelder@helmholtz-muenchen.de.

Publikováno v: Nature medicine [Nat Med] 2022 Mar; Vol. 28 (3), pp. 600.