Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Baktybek, Kojonazarov"'
Autor:
Jaco Selle, Katharina Dinger, Vanessa Jentgen, Daniela Zanetti, Johannes Will, Theodoros Georgomanolis, Christina Vohlen, Rebecca Wilke, Baktybek Kojonazarov, Oleksiy Klymenko, Jasmine Mohr, Silke v. Koningsbruggen-Rietschel, Christopher J. Rhodes, Anna Ulrich, Dharmesh Hirani, Tim Nestler, Margarete Odenthal, Esther Mahabir, Sreenath Nayakanti, Swati Dabral, Thomas Wunderlich, James Priest, Werner Seeger, Jörg Dötsch, Soni S. Pullamsetti, Miguel A. Alejandre Alcazar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
This study shows that maternal and perinatal obesity cause bronchial and vascular smooth muscle cell proliferation through an IL-6-FoxO1 axis, and favor thereby the emergence of bronchial obstruction and pulmonary hypertension later in life.
Externí odkaz:
https://doaj.org/article/b4419ac41c554af68c918ae4ee7c5d81
Autor:
Katharina Schäfer, Khodr Tello, Oleg Pak, Manuel Richter, Mareike Gierhardt, Grazyna Kwapiszewska, Christine Veith, Ludger Fink, Henning Gall, Matthias Hecker, Baktybek Kojonazarov, Simone Kraut, Kevin Lo, Jochen Wilhelm, Friedrich Grimminger, Werner Seeger, Ralph T. Schermuly, Hossein A. Ghofrani, Daniel Zahner, Rüdiger Gerstberger, Norbert Weissmann, Akylbek Sydykov, Natascha Sommer
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background The brain-derived neurotrophic factor (BDNF) may promote development of pulmonary hypertension and right ventricular (RV) failure. However, BDNF plasma levels were decreased in patients with left ventricular (LV) failure. Therefore, we inv
Externí odkaz:
https://doaj.org/article/9f7d0eddfb5141aeb352bb75bdbacf8a
Autor:
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Novoyatleva et al investigate the role of receptor tyrosine kinase Axl in Pulmonary arterial hypertension (PAH), finding that the small molecule inhibitor R428 reduces human pulmonary arterial smooth muscle cells proliferation and migration, but caus
Externí odkaz:
https://doaj.org/article/9cdae1283c834b96804aa01aec8d92af
Autor:
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/6372acf160c0422196d52dd2b5dbb095
Autor:
Mario Boehm, Nadine Arnold, Adam Braithwaite, Josephine Pickworth, Changwu Lu, Tatyana Novoyatleva, David G. Kiely, Friedrich Grimminger, Hossein A. Ghofrani, Norbert Weissmann, Werner Seeger, Allan Lawrie, Ralph T. Schermuly, Baktybek Kojonazarov
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/9128026f8ce84d0480b02f0afb9b357b
Autor:
Marija Gredic, Vinita Sharma, Stefan Hadzic, Cheng-Yu Wu, Oleg Pak, Baktybek Kojonazarov, Julia Duerr, Marcus A. Mall, Andreas Guenther, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Simone Kraut, Natascha Sommer, Norbert Weissmann
Publikováno v:
Cells, Vol 12, Iss 1, p 125 (2022)
Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In addition to chronic bronchitis and emphysema, patients often develop at least mild pulmonary hypertension (PH). We previously demonstrated that
Externí odkaz:
https://doaj.org/article/3008e0d7d92544d4b3191399a61fe647
Autor:
Astrid Weiss, Moritz Christian Neubauer, Dinesh Yerabolu, Baktybek Kojonazarov, Beate Christiane Schlueter, Lavinia Neubert, Danny Jonigk, Nelli Baal, Clemens Ruppert, Peter Dorfmuller, Soni Savai Pullamsetti, Norbert Weissmann, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that the
Externí odkaz:
https://doaj.org/article/4090a81f202846ada6a47e71478ee836
Autor:
Argen Mamazhakypov, Astrid Weiß, Sven Zukunft, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Christina Vroom, Aleksandar Petrovic, Djuro Kosanovic, Norbert Weissmann, Werner Seeger, Ingrid Fleming, Marc Iglarz, Friedrich Grimminger, Hossein A. Ghofrani, Soni S. Pullamsetti, Ralph T. Schermuly
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in pulmonary arterial hypertension. We investi
Externí odkaz:
https://doaj.org/article/f12a5a6e63d44ffdb2021cbce29d7c48
Autor:
Swathi Veeroju, Argen Mamazhakypov, Nabham Rai, Baktybek Kojonazarov, Valerie Nadeau, Sandra Breuils-Bonnet, Ling Li, Norbert Weissmann, Susanne Rohrbach, Steve Provencher, Sébastien Bonnet, Werner Seeger, Ralph Schermuly, Tatyana Novoyatleva
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234872 (2020)
The leading cause of death in Pulmonary Arterial Hypertension (PAH) is right ventricular (RV) failure. The tumor suppressor p53 has been associated with left ventricular hypertrophy (LVH) and remodeling but its role in RV hypertrophy (RVH) is unclear
Externí odkaz:
https://doaj.org/article/57096d2567ab4b56ae769415503176ac
Autor:
Mario Boehm, Nadine Arnold, Adam Braithwaite, Josephine Pickworth, Changwu Lu, Tatyana Novoyatleva, David G. Kiely, Friedrich Grimminger, Hossein A. Ghofrani, Norbert Weissmann, Werner Seeger, Allan Lawrie, Ralph T. Schermuly, Baktybek Kojonazarov
Publikováno v:
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces mortality and morbidity among patients with severe left-sided heart fail
Externí odkaz:
https://doaj.org/article/fd757802b5e44658b272e161690944d4