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Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer

Autor: Meghan P. Bouchie, Mihai Nita-Lazar, Maria A. Kukuruzinska, Zhen-nan Gao, Bakr Amin, Pritam K. Sengupta, Basem T Jamal, Sharuch Jalisi

Publikováno v: Oral Oncology. 48:523-529

Oral cancer is one of the most aggressive epithelial malignancies, whose incidence is on the rise. Previous studies have shown that in a subset of human oral squamous cell carcinoma (OSCC) tumor specimens, overexpression of the DPAGT1 gene, encoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7670a23fb81d4e51c374f36ae5793cd1
https://doi.org/10.1016/j.oraloncology.2012.01.010

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N-glycosylation status of E-cadherin controls cytoskeletal dynamics through the organization of distinct β-catenin- and γ-catenin-containing AJs

Autor: Janice L. Walker, Mihai Nita-Lazar, Bakr Amin, Zhen-nan Gao, Basem T Jamal, Maria A. Kukuruzinska

Publikováno v: Cell Health and Cytoskeleton. 1:67-80

N-glycosylation of E-cadherin has been shown to inhibit cell-cell adhesion. Specifically, our recent studies have provided evidence that the reduction of E-cadherin N-glycosylation promoted the recruitment of stabilizing components, vinculin and seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cbbf39f4e2c5194aa435b4f5bf95323
https://doi.org/10.2147/chc.s5965

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