Leptin Signaling Suppression in Macrophages Improves Immunometabolic Outcomes in Obesity.

Autor: Monteiro LB; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Prodonoff JS; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Favero de Aguiar C; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Correa-da-Silva F; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Castoldi A; Laboratory Keizo Asami, Immunopathology Laboratory, Federal University of Pernambuco, Pernambuco, Brazil., Bakker NVT; Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany., Davanzo GG; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Castelucci B; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Pereira JADS; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil.; Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, Brazil., Curtis J; Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.; Bloomberg Kimmel Institute and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD., Büscher J; Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany., Reis LMD; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Castro G; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Ribeiro G; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Virgílio-da-Silva JV; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil., Adamoski D; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Dias SMG; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Consonni SR; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil., Donato J; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Pearce EJ; Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.; Bloomberg Kimmel Institute and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD., Câmara NOS; Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, Brazil., Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster, University of Campinas, São Paulo, Brazil.; Obesity and Comorbidities Research Center, University of Campinas, São Paulo, Brazil.

Publikováno v: Diabetes [Diabetes] 2022 Jul 01; Vol. 71 (7), pp. 1546-1561.